Cooperation is the key: the CCN biological system as a gate to high complex protein superfamilies’ signaling

Aloe L, Rocco ML, Bianchi P, Manni L (2012) Nerve growth factor: from the early discoveries to the potential clinical use. J Transl Med 10:239

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ball DK, Surveyor GA, Diehl JR, Steffen CL, Uzumcu M, Mirando MA, Brigstock DR (1998) Characterization of 16- to 20- kilodalton (kDa) connective tissue growth factors (CTGFs) and demonstration of proteolytic activity for 38-kDa CTGF in pig uterine luminal flushings. Biol Reprod 59:828–835

Article  CAS  PubMed  Google Scholar 

Bleau AM, Planque N, Lazar N, Zambelli D, Ori A, Quan T, Fisher G, Scotlandi K, Perbal B (2007) Antiproliferative activity of CCN3: involvement of the C-terminal module and post-translational regulation. J Cell Biochem 101:1475–1491

Article  CAS  PubMed  Google Scholar 

Bork P (1993) The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett 327:125–130

Article  CAS  PubMed  Google Scholar 

Brigstock DR, Steffen CL, Kim GY, Vegunta RK, Diehl JR, Harding PA (1997) Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids. Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor. J Biol Chem 272:20275–20282

Article  CAS  PubMed  Google Scholar 

Brigstock DR (1999) The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev 20:189–206

CAS  PubMed  Google Scholar 

Del Caño-Ochoa F, Ramón-Maiques S (2021) Deciphering CAD: structure and function of a mega-enzymatic pyrimidine factory in health and disease. Prot Sci 30:1995–2008

Article  Google Scholar 

Fenton AW (2008) Allostery: an illustrated definition for the ‘second secret of life.’ Trends Biochem Sci 33:420–425

Article  CAS  PubMed  PubMed Central  Google Scholar 

Furlan M (1996) Von Willebrand factor: molecular size and functional activity. Ann Hematol 72:341–348

Article  CAS  PubMed  Google Scholar 

Garrett EC, Bielawski AM, Ruchti E, Sherer LM, Waghmare I, Hess-Homeier D, McCabe BD, Stowers RS, Certel SJ (2023) The matricellular protein drosophila cellular communication network factor is required for synaptic transmission and female fertility. Genet Adv

Herpin A, Lelong C, Favrel P (2004) Transforming growth factor-beta-related proteins: an ancestral and widespread superfamily of cytokines in metazoans. Dev Comp Immunol 28:461–485

Article  CAS  PubMed  Google Scholar 

Holbourn KP, Perbal B, Acharya KR (2009) Proteins on the catwalk: modelling the structural domains of the CCN family of proteins. J Cell Commun Signal 3:25–41

Article  PubMed  PubMed Central  Google Scholar 

Holmes DI, Zachary I (2005) The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. Genome Biol 6:209–210

Article  PubMed  PubMed Central  Google Scholar 

Hwa V, Oh Y, Rosenfeld RG (1999) The insulin-like growth factor-binding protein (IGFBP) superfamily. Endocr Rev 20:761–787

CAS  PubMed  Google Scholar 

Hu K, Tao Y, Li J, Liu Z, Zhu X, Wang Z (2019) A comparative genomic and phylogenetic analysis of the origin and evolution of the CCN gene family. Biomed Res Int 19:8620878

Google Scholar 

Iyer S, Acharya KR (2011) Tying the knot: the cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines. FEBS J 278:4304–4322

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joliot V, Martinerie C, Dambrine G, Plassiart G, Brisac M, Crochet J, Perbal B (1992) Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1- induced nephroblastomas. Mol Cell Biol 12:10–21

CAS  PubMed  PubMed Central  Google Scholar 

Kaasbøll OJ, Gadicherla AK, Wang JH, Monsen VT, Hagelin EMV, Dong MQ, Attramadal H (2018) Connective tissue growth factor (CCN2) is a matricellular preproprotein controlled by proteolytic activation. J Biol Chem 293:17953–17970

Article  PubMed  PubMed Central  Google Scholar 

Lacroute F (1968) Regulation of pyrimidine biosynthesis in saccharomyces cerevisiae. J Bact 95:824–832

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lau LF, Lam SC (1999) The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res 248:44–57

Article  CAS  PubMed  Google Scholar 

Lau LF (2016) Cell surface receptors for CCN proteins. J Cell Commun Signal 10:121–127

Article  PubMed  PubMed Central  Google Scholar 

Lazar N, Manara C, Navarro S, Bleau AM, Llombart-Bosch A, Scotlandi K, Planque N, Perbal B (2007) Domain-specific CCN3 antibodies as unique tools for structural and functional studies. J Cell Commun Signal 1:91–102

Article  PubMed  PubMed Central  Google Scholar 

Lunenfeld B (2004) Historical perspectives in gonadotrophin therapy. Hum Reprod Update 10:453–467

Article  CAS  PubMed  Google Scholar 

Meng X, Nikolic-Paterson DJ, Lan HY (2016) TGF-β: the master regulator of fibrosis. Nat Rev Nephrol 12:325–338

Article  CAS  PubMed  Google Scholar 

Monod J, Changeux JP, Jacob F (1963) Allosteric proteins and cellular control systems. J Mol Biol 6:306–329

Article  CAS  PubMed  Google Scholar 

Morlon H (2014) Phylogenetic approaches for studying diversification. Ecol Lett. https://doi.org/10.1111/ele.12251

Article  PubMed  Google Scholar 

Perbal B (1999) Nuclear localization of NOV protein: a potential role for nov in the regulation of gene expression. Mol Pathol 52:84–91

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perbal B (2001) NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues. Mol Pathol 54:57–79

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perbal B (2004) CCN proteins: multifunctional signalling regulators. Lancet 363:62–64

Article  CAS  PubMed  Google Scholar 

Perbal B (2009) Alternative splicing of CCN mRNAs it has been upon us. J Cell Commun Signal 3:153–157

Article  PubMed  PubMed Central  Google Scholar 

Perbal B (2013) CCN proteins: a centralized communication network. J Cell Commun Signal 7:169–177

Article  PubMed  PubMed Central  Google Scholar 

Perbal B (2018) The concept of the CCN protein family revisited: a centralized coordination network. J Cell Commun Signal 12:3–12

Article  PubMed  PubMed Central  Google Scholar 

Perbal B (2019) CCN proteins are part of a multilayer complex system: a working model. J Cell Commun Signal 13:437–439

Article  PubMed  PubMed Central  Google Scholar 

Perbal B (2023) Time has come to address the spatiotemporal combinatorial model for CCN proteins biological activitites by spatial transcriptomics and genome wide association studies. J Cell Commun Signal 8:1–3

Article  Google Scholar 

Perbal B, Tweedie S, Bruford E (2018) The official unified nomenclature adopted by the HGNC calls for the use of the acronyms, CCN1–6, and discontinuation in the use of CYR61, CTGF, NOV and WISP 1–3 respectively. J Cell Commun Signal 12:625–629

Article  PubMed  PubMed Central  Google Scholar 

Planque N, Perbal B (2003) A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis. Cancer Cell Int 3(1):15

Article  PubMed  PubMed Central  Google Scholar 

Richard D, Liu Z, Cao J, Kiapour AM, Willen J, Yarlagadda S, Jagoda E, Kolachalama VB, Sieker JT, Chang GH, Muthuirulan P, Young M, Masson A, Konrad J, Hosseinzadeh S, Maridas DE, Rosen V, Krawetz R, Roach N, Capellini TD (2020) Evolutionary selection and constraint on human knee chondrocyte regulation impacts osteoarthritis risk. Cell 181:362–381

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rittié L, Perbal B, Castellot JJ Jr, Orringer JS, Voorhees JJ, Fisher GJ (2011) Spatial-temporal modulation of CCN proteins during wound healing in human skin in vivo. J Cell Commun Signal 5:69–80

Article  PubMed  PubMed Central  Google Scholar 

Roschger C, Cabrele C (2017) The Id-protein family in developmental and cancer-associated pathways. Cell Commun Signal 15(1):7

Article  PubMed  PubMed Central 

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