Dual Inhibition of the Wnt Inhibitors DKK1 and Sclerostin Promotes Fracture Healing and Increases the Density and Strength of Uninjured BoneAn Experimental Study in Nonhuman Primates

1Discovery Research, Amgen, Thousand Oaks, California

2Phylon Pharma Services, Thousand Oaks, California

3University of Michigan School of Dentistry, Ann Arbor, Michigan

4Angitia Biopharmaceuticals, Guangzhou, Guangdong, People’s Republic of China

5Ascendis Pharma, Palo Alto, California

aEmail for corresponding author: [email protected]

Investigation performed at PharmaLegacy, Shanghai, People’s Republic of China, and Amgen, Thousand Oaks, California

Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (https://links.lww.com/JBJS/H512).

*Monica Florio, PhD, and Paul J. Kostenuik, PhD, contributed equally to this work.

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