A distal lung organoid model to study interstitial lung disease, viral infection and human lung development

Clevers, H. Modeling development and disease with organoids. Cell 165, 1586–1597 (2016).

Article  CAS  PubMed  Google Scholar 

McCauley, H. A. & Wells, J. M. Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish. Development 144, 958–962 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miller, A. J. & Spence, J. R. In vitro models to study human lung development, disease and homeostasis. Physiology 32, 246–260 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Basil, M. C. et al. The cellular and physiological basis for lung repair and regeneration: past, present, and future. Cell Stem Cell 26, 482–502 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herriges, M. & Morrisey, E. E. Lung development: orchestrating the generation and regeneration of a complex organ. Development 141, 502–513 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Basil, M. C. et al. Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Nature 604, 120–126 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Habermann, A. C. et al. Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis. Sci. Adv. 6, eaba1972 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kadur Lakshminarasimha Murthy, P. et al. Human distal lung maps and lineage hierarchies reveal a bipotent progenitor. Nature 604, 111–119 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morrisey, E. E. & Hogan, B. L. Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev. Cell 18, 8–23 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burri, P. H. Fetal and postnatal development of the lung. Annu. Rev. Physiol. 46, 617–628 (1984).

Article  CAS  PubMed  Google Scholar 

Nikolić, M. Z., Sun, D. & Rawlins, E. L. Human lung development: recent progress and new challenges. Development 145, dev163485 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Herring, M. J., Putney, L. F., Wyatt, G., Finkbeiner, W. E. & Hyde, D. M. Growth of alveoli during postnatal development in humans based on stereological estimation. Am. J. Physiol. Lung Cell. Mol. Physiol. 307, L338–L344 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dye, B. R. et al. A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids. eLife 5, e19732 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Dye, B. R. et al. In vitro generation of human pluripotent stem cell derived lung organoids. eLife 4, e05098 (2015).

Article  PubMed  PubMed Central  Google Scholar 

Nikolic, M. Z. et al. Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids. eLife 6, e26575 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Dekkers, J. F. et al. Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis. Sci. Transl. Med. 8, 344ra84 (2016).

Article  PubMed  Google Scholar 

Salahudeen, A. A. et al. Progenitor identification and SARS-CoV-2 infection in human distal lung organoids. Nature 588, 670–675 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lamers, M. M. et al. An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells. EMBO J. 40, e105912 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacob, A. et al. Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells. Cell Stem Cell 21, 472–488.e10 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, Y. W. et al. A three-dimensional model of human lung development and disease from pluripotent stem cells. Nat. Cell Biol. 19, 542–549 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carvalho, A. L. R. T. de et al. Glycogen synthase kinase 3 induces multilineage maturation of human pluripotent stem cell-derived lung progenitors in 3D culture. Development 146, dev171652 (2019).

PubMed  PubMed Central  Google Scholar 

Miller, A. J. et al. Generation of lung organoids from human pluripotent stem cells in vitro. Nat. Protoc. 14, 518–540 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hawkins, F. J. et al. Derivation of airway basal stem cells from human pluripotent stem cells. Cell Stem Cell 28, 79–95.e8 (2021).

Article  CAS  PubMed  Google Scholar 

Gotoh, S. et al. Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells. Stem Cell Rep. 3, 394–403 (2014).

Article  CAS  Google Scholar 

Masui, A., Hirai, T. & Gotoh, S. Perspectives of future lung toxicology studies using human pluripotent stem cells. Arch. Toxicol. 96, 389–402 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Konishi, S. et al. Directed induction of functional multi-ciliated cells in proximal airway epithelial spheroids from human pluripotent stem cells. Stem Cell Rep. 6, 18–25 (2016).

Article  CAS  Google Scholar 

Porotto, M. et al. Authentic modeling of human respiratory virus infection in human pluripotent stem cell-derived lung organoids. mBio 10, e00723-19 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Strikoudis, A. et al. Modeling of fibrotic lung disease using 3D organoids derived from human pluripotent stem cells. Cell Rep. 27, 3709–3723.e5 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Green, M. D. et al. Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat. Biotechnol. 29, 267–272 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang, S. X. et al. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat. Biotechnol. 32, 84–91 (2014).

Article  CAS  PubMed  Google Scholar 

Roost, M. S. et al. KeyGenes, a tool to probe tissue differentiation using a human fetal transcriptional atlas. Stem Cell Rep. 4, 1112–1124 (2015).

Article  CAS  Google Scholar 

Hogan, B. L. et al. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell 15, 123–138 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Renzoni, E. A., Poletti, V. & Mackintosh, J. A. Disease pathology in fibrotic interstitial lung disease: is it all about usual interstitial pneumonia? Lancet 398, 1437–1449 (2021).

Article  CAS  PubMed  Google Scholar 

Lederer, D. J. & Martinez, F. J. Idiopathic pulmonary fibrosis. N. Engl. J. Med. 378, 1811–1823 (2018).

Article  CAS  PubMed  Google Scholar 

Katzen, J. & Beers, M. F. Contributions of alveolar epithelial cell quality control to pulmonary fibrosis. J. Clin. Invest. https://doi.org/10.1172/jci139519 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Armanios, M. Syndromes of telomere shortening. Annu. Rev. Genomics Hum. Genet. 10, 45–61 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Armanios, M. Telomerase mutations and the pulmonary fibrosis-bone marrow failure syndrome complex. N. Engl. J. Med. 367, 384 (2012).

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