Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34.

Article  PubMed  Google Scholar 

Znaor A, Lortet-Tieulent J, Laversanne M, Jemal A, Bray F. International variations and trends in renal cell carcinoma incidence and mortality. Eur Urol. 2015;67(3):519–30.

Article  PubMed  Google Scholar 

Yin L, Li W, Xu A, et al. SH3BGRL2 inhibits growth and metastasis in clear cell renal cell carcinoma via activating hippo/TEAD1-Twist1 pathway. EBioMedicine. 2020;51: 102596.

Article  PubMed  PubMed Central  Google Scholar 

Lalani AA, McGregor BA, Albiges L, et al. Systemic treatment of metastatic clear cell renal cell carcinoma in 2018: current paradigms, use of immunotherapy, and future directions. Eur Urol. 2019;75(1):100–10.

Article  PubMed  Google Scholar 

Fendler A, Bauer D, Busch J, et al. Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients. Nat Commun. 2020;11(1):929.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsvetkov P, Coy S, Petrova B, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins [published correction appears in Science. Science. 2022;375(6586):1254–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kahlson MA, Dixon SJ. Copper-induced cell death. Science. 2022;375(6586):1231–2.

Article  CAS  PubMed  Google Scholar 

Brewer GJ. Copper control as an antiangiogenic anticancer therapy: lessons from treating Wilson’s disease. Exp Biol Med (Maywood). 2001;226(7):665–73.

Article  CAS  PubMed  Google Scholar 

Larson CA, Blair BG, Safaei R, Howell SB. The role of the mammalian copper transporter 1 in the cellular accumulation of platinum-based drugs. Mol Pharmacol. 2009;75(2):324–30.

Article  CAS  PubMed  Google Scholar 

Zhang X, Yang Q. Association between serum copper levels and lung cancer risk: a meta-analysis. J Int Med Res. 2018;46(12):4863–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baltaci AK, Dundar TK, Aksoy F, Mogulkoc R. Changes in the serum levels of trace elements before and after the operation in thyroid cancer patients. Biol Trace Elem Res. 2017;175(1):57–64.

Article  CAS  PubMed  Google Scholar 

Basu S, Singh MK, Singh TB, Bhartiya SK, Singh SP, Shukla VK. Heavy and trace metals in carcinoma of the gallbladder. World J Surg. 2013;37(11):2641–6.

Article  PubMed  Google Scholar 

Ding X, Jiang M, Jing H, et al. Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong China. Environ Sci Pollut Res Int. 2015;22(10):7930–5.

Article  CAS  PubMed  Google Scholar 

Saleh SAK, Adly HM, Abdelkhaliq AA, Nassir AM. Serum levels of selenium, zinc, copper, manganese, and iron in prostate cancer patients. Curr Urol. 2020;14(1):44–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Y, Hou W, Song X, et al. Ferroptosis: process and function. Cell Death Differ. 2016;23(3):369–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manz DH, Blanchette NL, Paul BT, Torti FM, Torti SV. Iron and cancer: recent insights. Ann N Y Acad Sci. 2016;1368(1):149–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen P, Li X, Zhang R, et al. Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation. Theranostics. 2020;10(11):5107–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Zhao G, Condello S, et al. Frizzled-7 identifies platinum-tolerant ovarian cancer cells susceptible to ferroptosis. Cancer Res. 2021;81(2):384–99.

Article  CAS  PubMed  Google Scholar 

Klevay LM. IHD from copper deficiency: a unified theory. Nutr Res Rev. 2016;29(2):172–9.

Article  CAS  PubMed  Google Scholar 

LaVaute T, Smith S, Cooperman S, et al. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet. 2001;27(2):209–14.

Article  CAS  PubMed  Google Scholar 

Gupta A, Lutsenko S. Human copper transporters: mechanism, role in human diseases and therapeutic potential. Future Med Chem. 2009;1(6):1125–42.

Article  CAS  PubMed  Google Scholar 

Wee NK, Weinstein DC, Fraser ST, Assinder SJ. The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease. Int J Biochem Cell Biol. 2013;45(5):960–3.

Article  CAS  PubMed  Google Scholar 

Gao J, Zhao N, Knutson MD, Enns CA. The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. J Biol Chem. 2008;283(31):21462–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Doguer C, Ha JH, Collins JF. Intersection of Iron and Copper Metabolism in the Mammalian Intestine and Liver. Compr Physiol. 2018;8(4):1433–61.

Article  PubMed  PubMed Central  Google Scholar 

Zhang G, Sun J, Zhang X. A novel Cuproptosis-related LncRNA signature to predict prognosis in hepatocellular carcinoma. Sci Rep. 2022;12(1):11325.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bian Z, Fan R, Xie L. A novel cuproptosis-related prognostic gene signature and validation of differential expression in clear cell renal cell carcinoma. Genes (Basel). 2022;13(5):851.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Shi J, Liu X, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018;20(10):1181–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang W, Green M, Choi JE, et al. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569(7755):270–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Liu Y, Ye S, Feng H, Ma L. Development and validation of cuproptosis-related gene signature in the prognostic prediction of liver cancer. Front Oncol. 2022;12: 985484.

Article  PubMed  PubMed Central  Google Scholar 

Bao JH, Lu WC, Duan H, et al. Identification of a novel cuproptosis-related gene signature and integrative analyses in patients with lower-grade gliomas. Front Immunol. 2022;13: 933973.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Z, Li T, Xiao C, et al. Prediction of overall survival based upon a new ferroptosis-related gene signature in patients with clear cell renal cell carcinoma. World J Surg Oncol. 2022;20(1):120.

Article  PubMed  PubMed Central  Google Scholar 

Yu J, Mao W, Xu B, Chen M. Construction and validation of an autophagy-related long noncoding RNA signature for prognosis prediction in kidney renal clear cell carcinoma patients. Cancer Med. 2021;10(7):2359–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xing Q, Ji C, Zhu B, Cong R, Wang Y. Identification of small molecule drugs and development of a novel autophagy-related prognostic signature for kidney renal clear cell carcinoma. Cancer Med. 2020;9(19):7034–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong B, Zhou J, Ma K, et al. TRIB3 promotes the proliferation and invasion of renal cell carcinoma cells via activating MAPK signaling pathway. Int J Biol Sci. 2019;15(3):587–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Zhang W, Chuang GC, et al. Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess. Am J Physiol Endocrinol Metab. 2012;303(7):E908–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eyers