Backes CH, Hill KD, Shelton EL, Slaughter JL, Lewis TR, Weisz DE, et al. Patent ductus arteriosus: a contemporary perspective for the pediatric and adult cardiac care provider. J Am Heart Assoc. 2022;11:e025784.

Article  PubMed  PubMed Central  Google Scholar 

Semberova J, Sirc J, Miletin J, Kucera J, Berka I, Sebkova S, et al. Spontaneous closure of patent ductus arteriosus in infants ≤1500 g. Pediatrics. 2017;140:e20164258.

Article  PubMed  Google Scholar 

Benitz WE. Committee on Fetus and Newborn, American Academy of Pediatrics. Patent ductus arteriosus in preterm infants. Pediatrics. 2016;137. https://doi.org/10.1542/peds.2015-3730.

Nelson RJ, Thibeault DW, Emmanouilides GC, Lippmann M. Improving the results of ligation of patent ductus arteriosus in small preterm infants. J Thorac Cardiovasc Surg. 1976;71:169–78.

Article  CAS  PubMed  Google Scholar 

Hammerman C, Bin-Nun A, Markovitch E, Schimmel MS, Kaplan M, Fink D. Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. Pediatrics. 2011;128:e1618–e1621.

Article  PubMed  Google Scholar 

Manalastas M, Zaheer F, Nicoski P, Weiss MG, Amin S. Acetaminophen therapy for persistent patent ductus arteriosus. NeoReviews. 2021;22:e320–e331.

Article  PubMed  Google Scholar 

Stark A, Smith PB, Hornik CP, Zimmerman KO, Hornik CD, Pradeep S, et al. Medication use in the neonatal intensive care unit and changes from 2010 to 2018. J Pediatr. 2022;240:66–71.e4.

Article  PubMed  Google Scholar 

Al-Turkait A, Szatkowski L, Choonara I, Ojha S. Drug utilisation in neonatal units in England and Wales: a national cohort study. Eur J Clin Pharm. 2022;78:669–77.

Article  Google Scholar 

Gouyon B, Martin-Mons S, Iacobelli S, Razafimahefa H, Kermorvant-Duchemin E, Brat R, et al. Characteristics of prescription in 29 Level 3 Neonatal Wards over a 2-year period (2017-8). An inventory for future research. PLOS One. 2019;14:e0222667.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liebowitz M, Kaempf J, Erdeve O, Bulbul A, Håkansson S, Lindqvist J, et al. Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320). J Perinatol. 2019;39:599–607.

Article  PubMed  PubMed Central  Google Scholar 

Dani C, Mosca F, Cresi F, Lago P, Lista G, Laforgia N, et al. Patent ductus arteriosus in preterm infants born at 23–24 weeks’ gestation: Should we pay more attention? Early Hum Dev. 2019;135:16–22.

Article  PubMed  Google Scholar 

Mukherjee A, Jadhav V, Gupta A. Off-label use of paracetamol in managing patent ductus arteriosus across neonatal intensive care units in the UK. Arch Dis Child Fetal Neonatal Ed. 2021;106:113–4.

Article  PubMed  Google Scholar 

Dowd LA, Wheeler BJ, Al-Sallami HS, Broadbent RS, Edmonds LK, Medlicott NJ. Paracetamol treatment for patent ductus arteriosus: practice and attitudes in Australia and New Zealand. J Matern Fetal Neonatal Med. 2019;32:3039–44.

Article  CAS  PubMed  Google Scholar 

Jasani B, Mitra S, Shah PS. Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. Cochrane Database Syst Rev. 2022, https://doi.org/10.1002/14651858.CD010061.pub5.

Jasani B, Weisz DE, McNamara PJ. Evidence-based use of acetaminophen for hemodynamically significant ductus arteriosus in preterm infants. Semin Perinatol. 2018;42:243–52.

Article  CAS  PubMed  Google Scholar 

Squires RH. Acute liver failure in children. Semin Liver Dis. 2008;28:153–66.

Article  CAS  PubMed  Google Scholar 

Lee WS, McKiernan P, Kelly DA. Etiology, outcome and prognostic indicators of childhood fulminant hepatic failure in the United Kingdom. J Pediatr Gastroenterol Nutr. 2005;40:575–81.

Article  PubMed  Google Scholar 

Squires RH, Shneider BL, Bucuvalas J, Alonso E, Sokol RJ, Narkewicz MR, et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr. 2006;148:652–658.e2.

Article  PubMed  PubMed Central  Google Scholar 

Wright CJ. Acetaminophen and the developing lung: could there be lifelong consequences? J Pediatr. 2021;235:264–276.e1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McCulley DJ, Jensen EA, Sucre JMS, McKenna S, Sherlock LG, Dobrinskikh E, et al. Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures. Am J Physiol Lung Cell Mol Physiol. 2022;323:L1–L13.

Article  CAS  PubMed  Google Scholar 

Pacifici GM, Allegaert K. Clinical pharmacology of paracetamol in neonates: a review. Curr Ther Res. 2015;77:24–30.

Article  CAS  PubMed  Google Scholar 

McGill MR, Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013;30:2174–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramachandran A, Jaeschke H. Acetaminophen toxicity: novel insights into mechanisms and future perspectives. Gene Expr. 2018;18:19–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoon E, Babar A, Choudhary M, Kutner M, Pyrsopoulos N. Acetaminophen-induced hepatotoxicity: a comprehensive update. J Clin Transl Hepatol. 2016;4:131–42.

PubMed  PubMed Central  Google Scholar 

Sandoval J, Orlicky DJ, Allawzi A, Butler B, Ju C, Phan CT, et al. Toxic acetaminophen exposure induces distal lung ER stress, proinflammatory signaling, and emphysematous changes in the adult murine lung. Oxid Med Cell Longev. 2019;2019:1–15.

Article  Google Scholar 

Lee WM. Acetaminophen (APAP) hepatotoxicity—Isn’t it time for APAP to go away? J Hepatol. 2017;67:1324–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robinson JF, Hamilton EG, Lam J, Chen H, Woodruff TJ. Differences in cytochrome p450 enzyme expression and activity in fetal and adult tissues. Placenta. 2020;100:35–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sadler NC, Nandhikonda P, Webb-Robertson B-J, Ansong C, Anderson LN, Smith JN, et al. Hepatic cytochrome p450 activity, abundance, and expression throughout human development. Drug Metab Dispos. 2016;44:984–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hines RN. The ontogeny of drug metabolism enzymes and implications for adverse drug events. Pharm Ther. 2008;118:250–67.

Article  CAS  Google Scholar 

Hart SN, Cui Y, Klaassen CD, Zhong X. Three patterns of cytochrome P450 gene expression during liver maturation in mice. Drug Metab Dispos. 2009;37:116–21.

Article  CAS  PubMed  Google Scholar 

Xu S-F, Hu A-L, Xie L, Liu J-J, Wu Q, Liu J. Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats. PeerJ. 2019;7:e7429.

Article  PubMed  PubMed Central  Google Scholar 

Green MD, Shires TK, Fischer LJ. Hepatotoxicity of acetaminophen in neonatal and young rats. I. Age-related changes in susceptibility. Toxicol Appl Pharm. 1984;74:116–24.

Article  CAS  Google Scholar 

Hart JG, Timbrell JA. The effect of age on paracetamol hepatotoxicity in mice. Biochem Pharm. 1979;28:3015–7.

Article  CAS  PubMed  Google Scholar 

Oesch F, Fabian E, Landsiedel R. Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models. Arch Toxicol. 2019;93:3419–89.

Article  CAS  PubMed  Google Scholar 

Hukkanen J, Pelkonen O, Hakkola J, Raunio H. Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung. Crit Rev Toxicol. 2002;32:391–411.

Article  CAS  PubMed  Google Scholar 

Hart SG, Cartun RW, Wyand DS, Khairallah EA, Cohen SD. Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity. Fundam Appl Toxicol J Soc Toxicol. 1995;24:260–74.

Article  CAS  Google Scholar 

Placke ME, Wyand DS, Cohen SD. Extrahepatic lesions induced by acetaminophen in the mouse. Toxicol Pathol. 1987;15:381–7.

Article  CAS  PubMed  Google Scholar 

Jeffery EH, Haschek WM. Protection by dimethylsulfoxide against acetaminophen-induced hepatic, but not respiratory toxicity in the mouse. Toxicol Appl Pharm. 1988;93:452–61.

Article  CAS  Google Scholar 

Gu J, Cui H, Behr M, Zhang L, Zhang Q-Y, Yang W, et al. In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa. Mol Pharm. 2005;67:623–30.

Article  CAS  Google Scholar