Multisystemic Inflammatory Syndrome in Children and Kawasaki Disease: Parallels in Pathogenesis and Treatment

Kawasaki T. Kawasaki disease. Int J Rheum Dis. 2014;17(5):597–600. https://doi.org/10.1111/1756-185x.12408.

Article  PubMed  Google Scholar 

Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020;395(10237):1607–8. https://doi.org/10.1016/s0140-6736(20)31094-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed. 2020;91(1):157–60. https://doi.org/10.23750/abm.v91i1.9397.

Lo MS. A framework for understanding Kawasaki disease pathogenesis. Clin Immunol. 2020;214:108385. https://doi.org/10.1016/j.clim.2020.108385.

Onouchi Y, Gunji T, Burns JC, Shimizu C, Newburger JW, Yashiro M, et al. ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet. 2008;40(1):35–42. https://doi.org/10.1038/ng.2007.59.

Article  CAS  PubMed  Google Scholar 

Armaroli G, Verweyen E, Pretzer C, Kessel K, Hirono K, Ichida F, et al. Monocyte-derived interleukin-1β as the driver of S100A12-induced sterile inflammatory activation of human coronary artery endothelial cells: implications for the pathogenesis of Kawasaki disease. Arthritis Rheumatol. 2019;71(5):792–804. https://doi.org/10.1002/art.40784.

Article  CAS  PubMed  Google Scholar 

Jia S, Li C, Wang G, Yang J, Zu Y. The T helper type 17/regulatory T cell imbalance in patients with acute Kawasaki disease. Clin Exp Immunol. 2010;162(1):131–7. https://doi.org/10.1111/j.1365-2249.2010.04236.x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Noval Rivas M, Lee Y, Wakita D, Chiba N, Dagvadorj J, Shimada K, et al. CD8+ T cells contribute to the development of coronary arteritis in the Lactobacillus casei cell wall extract-induced murine model of Kawasaki disease. Arthritis Rheumatol. 2017;69(2):410–21. https://doi.org/10.1002/art.39939.

Article  CAS  PubMed  Google Scholar 

Yeung RS. Kawasaki disease: update on pathogenesis. Curr Opin Rheumatol. 2010;22(5):551–60. https://doi.org/10.1097/BOR.0b013e32833cf051.

Article  PubMed  Google Scholar 

Doi M, Takeda T, Sakurai Y, Kato J, Hayashi T, Fukuda K, et al. Altered immunoglobulin A and M levels associated with changes in BAFF and APRIL after administration of intravenous immunoglobulin to treat Kawasaki disease. J Investig Allergol Clin Immunol. 2010;20(5):413–8.

Rowley AH, Eckerley CA, Jäck HM, Shulman ST, Baker SC. IgA plasma cells in vascular tissue of patients with Kawasaki syndrome. J Immunol. 1997;159(12):5946–55.

Article  CAS  PubMed  Google Scholar 

Noval Rivas M, Wakita D, Franklin MK, Carvalho TT, Abolhesn A, Gomez AC, et al. Intestinal permeability and IgA provoke immune vasculitis linked to cardiovascular inflammation. Immunity. 2019;51(3):508-21.e6. https://doi.org/10.1016/j.immuni.2019.05.021.

Article  CAS  PubMed  Google Scholar 

Chua PK, Melish ME, Yu Q, Yanagihara R, Yamamoto KS, Nerurkar VR. Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. Clin Diagn Lab Immunol. 2003;10(2):308–14. https://doi.org/10.1128/cdli.10.2.308-314.2003.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santos-Rebouças CB, Piergiorge RM, Dos Santos FC, SeixasZeitel R, Gerber AL, Rodrigues MCF, et al. Host genetic susceptibility underlying SARS-CoV-2-associated multisystem inflammatory syndrome in Brazilian children. Mol Med. 2022;28(1):153. https://doi.org/10.1186/s10020-022-00583-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abolhassani H, Delavari S, Landegren N, Shokri S, Bastard P, Du L, et al. Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19. J Allergy Clin Immunol. 2022;150(5):1059–73. https://doi.org/10.1016/j.jaci.2022.09.005.

Article  CAS  PubMed  PubMed Central  Google Scholar 

• Chou J, Platt CD, Habiballah S, Nguyen AA, Elkins M, Weeks S, et al. Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C). J Allergy Clin Immunol. 2021;148(3):732–8.e1. https://doi.org/10.1016/j.jaci.2021.06.024. A single-center cohort study demonstrating MIS-C patients were enriched for monogenic susceptibility to inflammation.

Lee PY, Platt CD, Weeks S, Grace RF, Maher G, Gauthier K, et al. Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. J Allergy Clin Immunol. 2020;146(5):1194-200.e1. https://doi.org/10.1016/j.jaci.2020.07.033.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carter MJ, Fish M, Jennings A, Doores KJ, Wellman P, Seow J, et al. Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection. Nat Med. 2020;26(11):1701–7. https://doi.org/10.1038/s41591-020-1054-6.

Article  CAS  PubMed  Google Scholar 

Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase J, Burudpakdee C, et al. Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2. J Clin Invest. 2020;130(11):5967–75. https://doi.org/10.1172/jci140970.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, et al. Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations. Blood Adv. 2020;4(23):6051–63. https://doi.org/10.1182/bloodadvances.2020003471.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gruber CN, Patel RS, Trachtman R, Lepow L, Amanat F, Krammer F, et al. Mapping systemic inflammation and antibody responses in multisystem inflammatory syndrome in children (MIS-C). Cell. 2020;183(4):982-95.e14. https://doi.org/10.1016/j.cell.2020.09.034.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma C, Ganigara M, Galeotti C, Burns J, Berganza FM, Hayes DA, et al. Multisystem inflammatory syndrome in children and Kawasaki disease: a critical comparison. Nat Rev Rheumatol. 2021;17(12):731–48. https://doi.org/10.1038/s41584-021-00709-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vella LA, Giles JR, Baxter AE, Oldridge DA, Diorio C, Kuri-Cervantes L, et al. Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19. Sci Immunol. 2021;6(57). https://doi.org/10.1126/sciimmunol.abf7570.

Consiglio CR, Cotugno N, Sardh F, Pou C, Amodio D, Rodriguez L, et al. The immunology of multisystem inflammatory syndrome in children with COVID-19. Cell. 2020;183(4):968-81.e7. https://doi.org/10.1016/j.cell.2020.09.016.

Article  CAS  PubMed  PubMed Central  Google Scholar 

• Esteve-Sole A, Anton J, Pino-Ramirez RM, Sanchez-Manubens J, Fumadó V, Fortuny C, et al. Similarities and differences between the immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome and Kawasaki disease. J Clin Invest. 2021;131(6). https://doi.org/10.1172/jci144554. The study performed cytokine profiling in pediatric patients with MIS-C and pre-pandemic KD, and results suggest IFN-γ and inflammatory monocytes are important drivers of inflammation in MIS-C.

Holman RC, Belay ED, Christensen KY, Folkema AM, Steiner CA, Schonberger LB. Hospitalizations for Kawasaki syndrome among children in the United States, 1997–2007. Pediatr Infect Dis J. 2010;29(6):483–8. https://doi.org/10.1097/INF.0b013e3181cf8705.

Article  PubMed  Google Scholar 

Son MB, Gauvreau K, Ma L, Baker AL, Sundel RP, Fulton DR, et al. Treatment of Kawasaki disease: analysis of 27 US pediatric hospitals from 2001 to 2006. Pediatrics. 2009;124(1):1–8. https://doi.org/10.1542/peds.2008-0730.

Article  PubMed  Google Scholar 

Sundel RP. Kawasaki disease. Rheum Dis Clin North Am. 2015;41(1):63–73, viii. https://doi.org/10.1016/j.rdc.2014.09.010.

• Son MBF, Gauvreau K, Tremoulet AH, Lo M, Baker AL, de Ferranti S, et al. Risk model development and validation for prediction of coronary artery aneurysms in Kawasaki disease in a North American population. J Am Heart Assoc. 2019;8(11):e011319. https://doi.org/10.1161/jaha.118.011319. This study aims to develop a risk model predictive of coronary artery aneurysm development, a major determinant of Kawasaki disease morbidity, for North American cohorts.

Salgado AP, Ashouri N, Berry EK, Sun X, Jain S, Burns JC, et al. High Risk of Coronary Artery Aneurysms in Infants Younger than 6 Months of Age with Kawasaki Disease. J Pediatr. 2017;185:112-6.e1. https://doi.org/10.1016/j.jpeds.2017.03.025.

Article  PubMed  PubMed Central  Google Scholar 

Gámez-González LB, Murata C, Muñoz-Ramírez M, Yamazaki-Nakashimada M. Clinical manifestations associated with Kawasaki disease shock syndrome in Mexican children. Eur J Pediatr. 2013;172(3):337–42. https://doi.org/10.1007/s00431-012-1879-1.

Article  PubMed  Google Scholar 

Dufort EM, Koumans EH, Chow EJ, Rosenthal EM, Muse A, Rowlands J, et al. Multisystem inflammatory syndrome in children in New York State. N Engl J Med. 2020;383(4):347–58. https://doi.org/10.1056/NEJMoa2021756.

Article  CAS  PubMed  Google Scholar 

Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, et al. Multisystem inflammatory syndrome in U.S. children and adolescents. N Engl J Med. 2020;383(4):334–46. https://doi.org/10.1056/NEJMoa2021680.

Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P, et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA. 2020;324(3):259–69. https://doi.org/10.1001/jama.2020.10369.

Article  CAS  PubMed  PubMed Central  Google Scholar 

•• Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, et al. Characteristics and outcomes of US children and adolescents with multisystem inflammatory syndrome in children (MIS-C) compared with severe acute COVID-19. JAMA. 2021;325(11):1074–87. https://doi.org/10.1001/jama.2021.2091. This report is one of the largest case series including 539 children with MIS-C from the Overcoming COVID-19 surveillance registry. The study observed that most cardiovascular involvement resolved over time.

Susarla SC, Fan LL. Diffuse alveolar hemorrhage syndromes in children. Curr Opin Pediatr. 2007;19(3):314–20. https://doi.org/10.1097/MOP.0b013e3280dd8c4a.

Article  PubMed  Google Scholar 

Son MBF, Burns JC, Newburger JW. A new definition for multisystem inflammatory syndrome in children. Pediatr. 2023. https://doi.org/10.1542/peds.2022-060302.

Miller J, Cantor A, Zachariah P, Ahn D, Martinez M, Margolis KG. Gastrointestinal symptoms as a major presentation component of a novel multisystem inflammatory syndrome in children that is related to Coronavirus disease 2019: a single center experience of 44 cases. Gastroenterology. 2020;159(4):1571-4.e2. https://doi.org/10.1053/j.gastro.2020.05.079.

Article  CAS  PubMed  Google Scholar 

Baker AL, Lu M, Minich LL, Atz AM, Klein GL, Korsin R, et al. Associated symptoms in the ten days before diagnosis of Kawasaki disease. J Pediatr. 2009;154(4):592-5.e2. https://doi.org/10.1016/j.jpeds.2008.10.006.

Article  PubMed  Google Scholar 

McCrindle BW, Rowley AH, Newburger JW, Burns JC, Bolger AF, Gewitz M, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association. Circulation. 2017;135(17):e927–99. https://doi.org/10.1161/cir.0000000000000484.

Article  PubMed  Google Scholar 

Wu EY, Campbell MJ. Cardiac Manifestations of multisystem inflammatory syndrome in children (MIS-C) following COVID-19. Curr Cardiol Rep. 2021;23(11):168. https://doi.org/10.1007/s11886-021-01602-3.

Article  PubMed 

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