Diagnostic and prognostic performance of plasma neurofilament light chain in multiple system atrophy: a cross-sectional and longitudinal study

Poewe W, Stankovic I, Halliday G, Meissner WG, Wenning GK, Pellecchia MT, Seppi K, Palma JA, Kaufmann H (2022) Multiple system atrophy. Nat Rev Dis Primers 8:56. https://doi.org/10.1038/s41572-022-00382-6

Article  PubMed  Google Scholar 

Fanciulli A, Wenning GK (2015) Multiple-system atrophy. N Engl J Med 372:249–263. https://doi.org/10.1056/NEJMra1311488

Article  CAS  PubMed  Google Scholar 

Meissner WG, Fernagut PO, Dehay B, Péran P, Traon AP, Foubert-Samier A, Lopez Cuina M, Bezard E, Tison F, Rascol O (2019) Multiple system atrophy: recent developments and future perspectives. Mov Disord 34:1629–1642. https://doi.org/10.1002/mds.27894

Article  PubMed  Google Scholar 

Wenning GK, Stankovic I, Vignatelli L, Fanciulli A, Calandra-Buonaura G, Seppi K, Palma JA, Meissner WG, Krismer F, Berg D, Cortelli P, Freeman R, Halliday G, Höglinger G, Lang A, Ling H, Litvan I, Low P, Miki Y, Panicker J, Pellecchia MT, Quinn N, Sakakibara R, Stamelou M, Tolosa E, Tsuji S, Warner T, Poewe W, Kaufmann H (2022) The Movement Disorder Society Criteria for the diagnosis of multiple system atrophy. Mov Disord 37:1131–1148. https://doi.org/10.1002/mds.29005

Article  PubMed  PubMed Central  Google Scholar 

Koga S, Aoki N, Uitti RJ, van Gerpen JA, Cheshire WP, Josephs KA, Wszolek ZK, Langston JW, Dickson DW (2015) When DLB, PD, and PSP masquerade as MSA: an autopsy study of 134 patients. Neurology 85:404–412. https://doi.org/10.1212/wnl.0000000000001807

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cong S, Xiang C, Wang H, Cong S (2021) Diagnostic utility of fluid biomarkers in multiple system atrophy: a systematic review and meta-analysis. J Neurol 268:2703–2712. https://doi.org/10.1007/s00415-020-09781-9

Article  PubMed  Google Scholar 

Laurens B, Constantinescu R, Freeman R, Gerhard A, Jellinger K, Jeromin A, Krismer F, Mollenhauer B, Schlossmacher MG, Shaw LM, Verbeek MM, Wenning GK, Winge K, Zhang J, Meissner WG (2015) Fluid biomarkers in multiple system atrophy: a review of the MSA Biomarker Initiative. Neurobiol Dis 80:29–41. https://doi.org/10.1016/j.nbd.2015.05.004

Article  PubMed  Google Scholar 

Coon EA, Sletten DM, Suarez MD, Mandrekar JN, Ahlskog JE, Bower JH, Matsumoto JY, Silber MH, Benarroch EE, Fealey RD, Sandroni P, Low PA, Singer W (2015) Clinical features and autonomic testing predict survival in multiple system atrophy. Brain 138:3623–3631. https://doi.org/10.1093/brain/awv274

Article  PubMed  PubMed Central  Google Scholar 

Foubert-Samier A, Pavy-Le Traon A, Guillet F, Le-Goff M, Helmer C, Tison F, Rascol O, Proust-Lima C, Meissner WG (2020) Disease progression and prognostic factors in multiple system atrophy: a prospective cohort study. Neurobiol Dis 139:104813. https://doi.org/10.1016/j.nbd.2020.104813

Article  PubMed  Google Scholar 

Low PA, Reich SG, Jankovic J, Shults CW, Stern MB, Novak P, Tanner CM, Gilman S, Marshall FJ, Wooten F, Racette B, Chelimsky T, Singer W, Sletten DM, Sandroni P, Mandrekar J (2015) Natural history of multiple system atrophy in the USA: a prospective cohort study. Lancet Neurol 14:710–719. https://doi.org/10.1016/s1474-4422(15)00058-7

Article  PubMed  PubMed Central  Google Scholar 

Wenning GK, Geser F, Krismer F, Seppi K, Duerr S, Boesch S, Köllensperger M, Goebel G, Pfeiffer KP, Barone P, Pellecchia MT, Quinn NP, Koukouni V, Fowler CJ, Schrag A, Mathias CJ, Giladi N, Gurevich T, Dupont E, Ostergaard K, Nilsson CF, Widner H, Oertel W, Eggert KM, Albanese A, del Sorbo F, Tolosa E, Cardozo A, Deuschl G, Hellriegel H, Klockgether T, Dodel R, Sampaio C, Coelho M, Djaldetti R, Melamed E, Gasser T, Kamm C, Meco G, Colosimo C, Rascol O, Meissner WG, Tison F, Poewe W (2013) The natural history of multiple system atrophy: a prospective European cohort study. Lancet Neurol 12:264–274. https://doi.org/10.1016/s1474-4422(12)70327-7

Article  PubMed  PubMed Central  Google Scholar 

Khalil M, Teunissen CE, Otto M, Piehl F, Sormani MP, Gattringer T, Barro C, Kappos L, Comabella M, Fazekas F, Petzold A, Blennow K, Zetterberg H, Kuhle J (2018) Neurofilaments as biomarkers in neurological disorders. Nat Rev Neurol 14:577–589. https://doi.org/10.1038/s41582-018-0058-z

Article  CAS  PubMed  Google Scholar 

Bacioglu M, Maia LF, Preische O, Schelle J, Apel A, Kaeser SA, Schweighauser M, Eninger T, Lambert M, Pilotto A, Shimshek DR, Neumann U, Kahle PJ, Staufenbiel M, Neumann M, Maetzler W, Kuhle J, Jucker M (2016) Neurofilament light chain in blood and CSF as marker of disease progression in mouse models and in neurodegenerative diseases. Neuron 91:494–496. https://doi.org/10.1016/j.neuron.2016.07.007

Article  CAS  PubMed  Google Scholar 

Lin CH, Li CH, Yang KC, Lin FJ, Wu CC, Chieh JJ, Chiu MJ (2019) Blood NfL: a biomarker for disease severity and progression in Parkinson disease. Neurology 93:e1104–e1111. https://doi.org/10.1212/wnl.0000000000008088

Article  CAS  PubMed  Google Scholar 

Ashton NJ, Janelidze S, Al Khleifat A, Leuzy A, van der Ende EL, Karikari TK, Benedet AL, Pascoal TA, Lleó A, Parnetti L, Galimberti D, Bonanni L, Pilotto A, Padovani A, Lycke J, Novakova L, Axelsson M, Velayudhan L, Rabinovici GD, Miller B, Pariante C, Nikkheslat N, Resnick SM, Thambisetty M, Schöll M, Fernández-Eulate G, Gil-Bea FJ, López de Munain A, Al-Chalabi A, Rosa-Neto P, Strydom A, Svenningsson P, Stomrud E, Santillo A, Aarsland D, van Swieten JC, Palmqvist S, Zetterberg H, Blennow K, Hye A, Hansson O (2021) A multicentre validation study of the diagnostic value of plasma neurofilament light. Nat Commun 12:3400. https://doi.org/10.1038/s41467-021-23620-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weston PSJ, Poole T, Ryan NS, Nair A, Liang Y, Macpherson K, Druyeh R, Malone IB, Ahsan RL, Pemberton H, Klimova J, Mead S, Blennow K, Rossor MN, Schott JM, Zetterberg H, Fox NC (2017) Serum neurofilament light in familial Alzheimer disease: a marker of early neurodegeneration. Neurology 89:2167–2175. https://doi.org/10.1212/wnl.0000000000004667

Article  PubMed  PubMed Central  Google Scholar 

Illán-Gala I, Lleo A, Karydas A, Staffaroni AM, Zetterberg H, Sivasankaran R, Grinberg LT, Spina S, Kramer JH, Ramos EM, Coppola G, La Joie R, Rabinovici GD, Perry DC, Gorno-Tempini ML, Seeley WW, Miller BL, Rosen HJ, Blennow K, Boxer AL, Rojas JC (2021) Plasma tau and neurofilament light in frontotemporal lobar degeneration and Alzheimer disease. Neurology 96:e671–e683. https://doi.org/10.1212/wnl.0000000000011226

Article  PubMed  PubMed Central  Google Scholar 

Hansson O, Janelidze S, Hall S, Magdalinou N, Lees AJ, Andreasson U, Norgren N, Linder J, Forsgren L, Constantinescu R, Zetterberg H, Blennow K (2017) Blood-based NfL: a biomarker for differential diagnosis of parkinsonian disorder. Neurology 88:930–937. https://doi.org/10.1212/wnl.0000000000003680

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vacchiano V, Mastrangelo A, Zenesini C, Masullo M, Quadalti C, Avoni P, Polischi B, Cherici A, Capellari S, Salvi F, Liguori R, Parchi P (2021) Plasma and CSF neurofilament light chain in amyotrophic lateral sclerosis: a cross-sectional and longitudinal study. Front Aging Neurosci 13:753242. https://doi.org/10.3389/fnagi.2021.753242

Rojas JC, Karydas A, Bang J, Tsai RM, Blennow K, Liman V, Kramer JH, Rosen H, Miller BL, Zetterberg H, Boxer AL (2016) Plasma neurofilament light chain predicts progression in progressive supranuclear palsy. Ann Clin Transl Neurol 3:216–225. https://doi.org/10.1002/acn3.290

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marques TM, van Rumund A, Oeckl P, Kuiperij HB, Esselink RAJ, Bloem BR, Otto M, Verbeek MM (2019) Serum NFL discriminates Parkinson disease from atypical parkinsonisms. Neurology 92:e1479–e1486. https://doi.org/10.1212/wnl.0000000000007179

Article  PubMed  Google Scholar 

Zhang L, Cao B, Hou Y, Gu X, Wei Q, Ou R, Zhao B, Luo C, Shang H (2022) Neurofilament light chain predicts disease severity and progression in multiple system atrophy. Mov Disord 37:421–426. https://doi.org/10.1002/mds.28847

Article  CAS  PubMed  Google Scholar 

Chelban V, Nikram E, Perez-Soriano A, Wilke C, Foubert-Samier A, Vijiaratnam N, Guo T, Jabbari E, Olufodun S, Gonzalez M, Senkevich K, Laurens B, Péran P, Rascol O, Le Traon AP, Todd EG, Costantini AA, Alikhwan S, Tariq A, Lin Ng B, Muñoz E, Painous C, Compta Y, Junque C, Segura B, Zhelcheska K, Wellington H, Schöls L, Jaunmuktane Z, Kobylecki C, Church A, Hu MTM, Rowe JB, Leigh PN, Massey L, Burn DJ, Pavese N, Foltynie T, Pchelina S, Wood N, Heslegrave AJ, Zetterberg H, Bocchetta M, Rohrer JD, Marti MJ, Synofzik M, Morris HR, Meissner WG, Houlden H (2022) methoidNeurofilament light levels predict clinical progression and death in multiple system atrophy. Brain. https://doi.org/10.1093/brain/awac253

Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, Wood NW, Colosimo C, Dürr A, Fowler CJ, Kaufmann H, Klockgether T, Lees A, Poewe W, Quinn N, Revesz T, Robertson D, Sandroni P, Seppi K, Vidailhet M (2008) Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71:670–676. https://doi.org/10.1212/01.wnl.0000324625.00404.15

Article  CAS  PubMed  PubMed Central  Google Scholar 

Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G (2015) MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 30:1591–1601. https://doi.org/10.1002/mds.26424

Article  PubMed  Google Scholar 

Peng Y, Zhang Y, Chen Z, Peng H, Wan N, Zhang J, Tang J, Wang P, Xie Y, Cai Q, Liu S, Zhang X, Wang C, Yuan H, Li T, Wan L, Shi Y, Qiu R, Klockgether T, Tang B, Liao W, Jiang H (2020) Association of serum neurofilament light and disease severity in patients with spinocerebellar ataxia type 3. Neurology 95:e2977–e2987. https://doi.org/10.1212/wnl.0000000000010671

Article  CAS  PubMed  Google Scholar 

Vu L, An J, Kovalik T, Gendron T, Petrucelli L, Bowser R (2020) Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes. J Neurol Neurosurg Psychiatry 91:350–358. https://doi.org/10.1136/jnnp-2019-321916

Article  PubMed  Google Scholar 

Latourelle JC, Beste MT, Hadzi TC, Miller RE, Oppenheim JN, Valko MP, Wuest DM, Church BW, Khalil IG, Hayete B, Venuto CS (2017) Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson’s disease: a longitudinal cohort study and validation. Lancet Neurol 16:908–916. https://doi.org/10.1016/s1474-4422(17)30328-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sacino AN, Brooks M, McKinney AB, Thomas MA, Shaw G, Golde TE, Giasson BI (2014) Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker. J Neurosci 34:12368–12378. https://doi.org/10.1523/jneurosci.2102-14.2014

Article  PubMed  PubMed Central  Google Scholar 

Hu X, Yang Y, Gong D (2017) Cerebrospinal fluid levels of neurofilament light chain in multiple system atrophy relative to Parkinson’s disease: a meta-analysis. Neurol Sci 38:407–414. https://doi.org/10.1007/s10072-016-2783-7

Article  PubMed  Google Scholar 

Kalia LV, Lang AE (2015) Parkinson’s disease. Lancet 386:896–912. https://doi.org/10.1016/s0140-6736(14)61393-3

Article  CAS  PubMed  Google Scholar 

Tsukamoto K, Matsusue E, Kanasaki Y, Kakite S, Fujii S, Kami

留言 (0)

沒有登入
gif