Evidence of a third branch in the uncinate fasciculus and possible implications

The uncinate fasciculus (UF) is a ventral, anterior, associative C-shaped white matter bundle that connects the temporo-amygdala-orbitofrontal network, which is functionally dedicated to the integration of visceral and emotional states, cognition and behaviour.1 Issues in that network are shown with cognitive and behavioural symptoms characteristic of temporal lobe epilepsy, mood disorders and neurodegenerative dementias, including Alzheimer’s disease and semantic dementia. In animal studies, the disconnection of the UF causes impairment of object–reward association and learning temporally complex visual …

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