Expression in skin biopsies supports genetic evidence linking CAMKK2, P2X7R and P2X4R with HIV-associated sensory neuropathy

Affandi JS, Price P, Imran D, Yunihastuti E, Djauzi S, Cherry CL (2008) Can we predict neuropathy risk before stavudine prescription in a resource-limited setting? AIDS Res Hum Retroviruses 24:1281–1284

Article  CAS  PubMed  Google Scholar 

Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila TA, Mizuno H, Hirano T, Tagawa Y, Okuno H, Bito H (2009) Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. J Neurosci 29:13720–13729

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amadio S, Parisi C, Piras E, Fabbrizio P, Apolloni S, Montilli C, Luchetti S, Ruggieri S, Gasperini C, Laghi-Pasini F, Battistini L, Volonté C (2017) Modulation of P2X7 Receptor during Inflammation in Multiple Sclerosis. Front Immunol 8:1529

Article  PubMed  PubMed Central  Google Scholar 

Bakkers M, Merkies IS, Lauria G, Devigili G, Penza P, Lombardi R, Hermans MC, van Nes SI, De Baets M, Faber CG (2009) Intraepidermal nerve fiber density and its application in sarcoidosis. Neurology 73:1142–1148

Article  CAS  PubMed  Google Scholar 

Cao L, DeLeo JA (2008) CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain. Eur J Immunol 38:448–458

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cherry CL, Wesselingh SL, Lal L, McArthur JC (2005) Evaluation of a clinical screening tool for HIV-associated sensory neuropathies. Neurology 65:1778–1781

Article  PubMed  Google Scholar 

Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, Grahames CBA, Casula MA, Yiangou Y, Birch R, Anand P, Buell GN (2005) Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 114:386–396

Article  CAS  PubMed  Google Scholar 

Codocedo JF, Allard C, Godoy JA, Varela-Nallar L, Inestrosa NC (2012) SIRT1 regulates dendritic development in hippocampal neurons. PLoS ONE 7:e47073

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Virgilio F, Sarti AC (2018) Microglia P2X4 receptors as pharmacological targets for demyelinating diseases. EMBO Mol Med 10

Gaff J, Halstrom S, Temple SEL, Baltic S, Kamerman P, Price P (2018) Polymorphisms in P2X4R and CAMKK2 may affect TNFα production: Implications for a role in HIV-associated sensory neuropathy. Hum Immunol 79:224–227

Article  CAS  PubMed  Google Scholar 

Gaff J, Octaviana F, Ariyanto I, Cherry C, Laws SM, Price P (2019) Polymorphisms in CAMKK2 associate with susceptibility to sensory neuropathy in HIV patients treated without stavudine. J Neurovirol 25:814–824

Article  CAS  PubMed  Google Scholar 

Gaff J, Pillay P, Cherry C, Laws SM, Price P, Kamerman P (2020a) The role of CAMKK2 polymorphisms in HIV-associated sensory neuropathy in South Africans. J Neurol Sci 416:116987

Article  CAS  PubMed  Google Scholar 

Gaff J, Octaviana F, Pillay P, Mbenda HGN, Ariyanto IA, Gan JA, Cherry CL, Kamerman P, Laws SM, Price P (2020b) TNF-Block Genotypes Influence Susceptibility to HIV-Associated Sensory Neuropathy in Indonesians and South Africans. Int J Mol Sci 21

Gamer M, Lemon J, Singh I (2010) irr: Various Coefficients of Interrater Reliability and Agreement. Available via https://cran.r-project.org/web/packages/irr/index.html. Accessed 15 Jun 2021

Geraghty NJ, Watson D, Adhikary SR, Sluyter R (2016) P2X7 receptor in skin biology and diseases. World Journal of Dermatologyy 5:72

Article  Google Scholar 

Goullee H, Wadley AL, Cherry CL, Allcock RJ, Black M, Kamerman PR, Price P (2016) Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients. J Neurovirol 22:508–517

Article  CAS  PubMed  Google Scholar 

Guo Y, Xu X, Huang J, Wang Z, Li Z, Liu Z (2020) The Actions and Mechanisms of P2X7R and p38 MAPK Activation in Mediating Bortezomib-Induced Neuropathic Pain. Biomed Res Int 2020:8143754

Article  PubMed  PubMed Central  Google Scholar 

Hahn K, Robinson B, Anderson C, Li W, Pardo CA, Morgello S, Simpson D, Nath A (2008) Differential effects of HIV infected macrophages on dorsal root ganglia neurons and axons. Exp Neurol 210:30–40

Article  CAS  PubMed  Google Scholar 

Inoue K, Hosoi J, Denda M (2007) Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes. J Invest Dermatol 127:362–371

Article  CAS  PubMed  Google Scholar 

Jones G, Zhu Y, Silva C, Tsutsui S, Pardo CA, Keppler OT, McArthur JC, Power C (2005) Peripheral nerve-derived HIV-1 is predominantly CCR5-dependent and causes neuronal degeneration and neuroinflammation. Virology 334:178–193

Article  CAS  PubMed  Google Scholar 

Kokubo M, Nishio M, Ribar TJ, Anderson KA, West AE, Means AR (2009) BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. J Neurosci 29:8901–8913

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lauria G, Hsieh ST, Johansson O, Kennedy WR, Leger JM, Mellgren SI, Nolano M, Merkies IS, Polydefkis M, Smith AG, Sommer C, Valls-Solé J (2010) European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. Eur J Neurol 17:903–912, e944–909

Li Y, Xu W, McBurney MW, Longo VD (2008) SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab 8:38–48

Article  PubMed  PubMed Central  Google Scholar 

Liu CM, Wang RY, Saijilafu JZX, Zhang BY, Zhou FQ (2013) MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration. Genes Dev 27:1473–1483

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Prell T, Stubendorff B, Keiner S, Ringer T, Gunkel A, Tadic V, Goldhammer N, Malci A, Witte OW, Grosskreutz J (2016) Down-regulation of purinergic P2X7 receptor expression and intracellular calcium dysregulation in peripheral blood mononuclear cells of patients with amyotrophic lateral sclerosis. Neurosci Lett 630:77–83

Article  CAS  PubMed  Google Scholar 

Luchting B, Heyn J, Woehrle T, Rachinger-Adam B, Kreth S, Hinske LC, Azad SC (2016) Differential expression of P2X7 receptor and IL-1β in nociceptive and neuropathic pain. J Neuroinflammation 13:100

Article  PubMed  PubMed Central  Google Scholar 

Makoto T, Hidetoshi T-S, Kazuhide I (2012) P2X4R and P2X7R in neuropathic pain. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 1:513–521

Google Scholar 

McArthur JC, Stocks EA, Hauer P, Cornblath DR, Griffin JW (1998) Epidermal nerve fiber density: normative reference range and diagnostic efficiency. Arch Neurol 55:1513–1520

Article  CAS  PubMed  Google Scholar 

Moehring F, Cowie AM, Menzel AD, Weyer AD, Grzybowski M, Arzua T, Geurts AM, Palygin O, Stucky CL (2018) Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling. Elife 7

Mountford J, Octaviana F, Estiasari R, Setiawan DD, Ariyanto I, Lee S, Gaff J, Chew C, Jackaman C, Kamerman P, Cherry C, Price P (2018) Ex-vivo expression of chemokine receptors on cells surrounding cutaneous nerves in patients with HIV-associated sensory neuropathy. AIDS 32:431–441

Article  CAS  PubMed  Google Scholar 

Octaviana F, Safri AY, Setiawan DD, Estiasari R, Imran D, Ranakusuma T, Price P (2019) Neuropathic pain in HIV patients receiving ART without stavudine in an Indonesia Referral Hospital. J Neurol Sci 397:146–149

Article  CAS  PubMed  Google Scholar 

Octaviana F, Safri AY, Setiawan DD, Estiasari R, Imran D, Ranakusuma T, Affandi J, Cherry CL, Price P (2018) Detectable Plasma HIV RNA Is Associated With Sensory Neuropathy in Patients With HIV Treated Without Stavudine. J Acquir Immune Defic Syndr 79:e108–e110

Article  PubMed  Google Scholar 

Patel IG, Kamerman PR (2019) Colocalization of pain and reduced intraepidermal nerve fiber density in individuals with HIV-associated sensory neuropathy. Pain Rep 4:e778

Article  PubMed  Google Scholar 

Phillips TJ, Cherry CL, Cox S, Marshall SJ, Rice AS (2010) Pharmacological treatment of painful HIV-associated sensory neuropathy: a systematic review and meta-analysis of randomised controlled trials. PLoS ONE 5:e14433

Article  CAS  PubMed  PubMed Central  Google Scholar 

Phillips TJC, Brown M, Ramirez JD, Perkins J, Woldeamanuel YW, Williams ACC, Orengo C, Bennett DLH, Bodi I, Cox S, Maier C, Krumova EK, Rice ASC (2014) Sensory, psychological, and metabolic dysfunction in HIV-associated peripheral neuropathy: A cross-sectional deep profiling study. Pain 155:1846–1860

Article  PubMed  PubMed Central  Google Scholar 

Pillay P, Wadley AL, Cherry CL, Karstaedt AS, Kamerman PR (2019) Clinical diagnosis of sensory neuropathy in HIV patients treated with tenofovir: A 6-month follow-up study. J Peripher Nerv Syst 24:304–313

Article  CAS  PubMed  Google Scholar 

Polydefkis M, Yiannoutsos CT, Cohen BA, Hollander H, Schifitto G, Clifford DB, Simpson DM, Katzenstein D, Shriver S, Hauer P, Brown A, Haidich AB, Moo L, McArthur JC (2002) Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy. Neurology 58:115–119

Article  CAS  PubMed  Google Scholar 

R Core Team (2010) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. Available via https://www.r-project.org/. Accessed 15 Jun 2021

Racioppi L, Means AR (2012) Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. J Biol Chem 287:31658–31665

Article  CAS  PubMed  PubMed Central  Google Scholar 

Racioppi L, Noeldner PK, Lin F, Arvai S, Means AR (2012) Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses. J Biol Chem 287:11579–11591

Article 

留言 (0)

沒有登入
gif