These authors contributed equally: Xue Yang, Qing Li, Wenting Liu.

Department of Tumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, China

Xue Yang, Wenting Liu, Chen Zong, Lixin Wei & Zhipeng Han

Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer, Ministry of Education, Eastern Hepatobiliary Surgery Hospital/National Center for Liver Cancer, Naval Medical University, Shanghai, 200438, China

Xue Yang, Wenting Liu, Chen Zong, Lixin Wei & Zhipeng Han

The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Key Laboratory of Stem Cells and Medical Biomaterials of Jiangsu Province, Medical College of Soochow University, Soochow University, Suzhou, 215000, China

Xue Yang & Yufang Shi

Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy

Xue Yang & Yufang Shi

CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

Qing Li