Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions

Keywords

Brain energy metabolism

Astrocytes

Mass spectrometry

Neurodegenerative disorders

Alzheimer's disease

Parkinson's disease

Huntington's disease

Amyotrophic lateral sclerosis

Abbreviations18F-FDG

18F- Fluorodeoxyglucose

3-NPA

3-Nitropropionic acid

AAT

Aspartate aminotransferase

ALAT

Alanine aminotransferase

ALS

Amyotrophic lateral sclerosis

BCAA

Branched-chain amino acid

BCAT

Branched-chain amino acid aminotransferase

CNS

Central nervous system

fAD

Familial Alzheimer's disease

GAD

Glutamate decarboxylase

GDH

Glutamate dehydrogenase

GLT-1

Glutamate transporter-1

hiPSC

Human induced pluripotent stem cell

MPTP

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

NFT

Neurofibrillary tangle

NMR

Nuclear magnetic resonance

PAG

Phosphate-activated glutaminase

PDH

Pyruvate dehydrogenase

PPP

Pentose phosphate pathway

SNc

Substantia nigra pars compacta

SSADH

Succinic semialdehyde dehydrogenase

TCA

Tricarboxylic acid (cycle)

Data availability

Data will be made available on request.

© 2023 The Authors. Published by Elsevier Inc.

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