Point-to-point associations of drusen and hyperreflective foci volumes with retinal sensitivity in non-exudative age-related macular degeneration

Wong WL, Su X, Li X, Cheung CMG, Klein R, Cheng C-Y, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Heal. 2014;2:e106–e116.

Article  Google Scholar 

Owsley C, McGwin G, Scilley K, Kallies K. Development of a questionnaire to assess vision problems under low luminance in age-related maculopathy. Investig Ophthalmol Vis Sci. 2006;47:528–35.

Article  Google Scholar 

Scilley K, Jackson GR, Cideciyan AV, Maguire MG, Jacobson SG, Owsley C. Early age-related maculopathy and self-reported visual difficulty in daily life2 2The authors have no commercial interests in any device or product mentioned in this article. Ophthalmol. 2002;109:1235–42.

Article  Google Scholar 

Schmidt-Erfurth U, Chong V, Loewenstein A, Larsen M, Souied E, Schlingemann R, et al. Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA). Br J Ophthalmol 2014;98:1144–67.

Article  PubMed  Google Scholar 

Cocce KJ, Stinnett SS, Luhmann UFO, Vajzovic L, Horne A, Schuman SG, et al. Visual function metrics in early and intermediate dry age-related macular degeneration for use as clinical trial endpoints. Am J Ophthalmol 2018;189:127–38.

Article  PubMed  PubMed Central  Google Scholar 

Owsley C, Huisingh C, Clark ME, Jackson GR, McGwin G. Comparison of visual function in older eyes in the earliest stages of age-related macular degeneration to those in normal macular health. Curr Eye Res 2016;41:266–72.

Article  PubMed  Google Scholar 

Chandramohan A, Stinnett SS, Petrowski JT, Schuman SG, Toth CA, Cousins SW, et al. Visual function measures in early and intermediate age-related macular degeneration. Retina 2016;36:1021–31.

Article  PubMed  PubMed Central  Google Scholar 

Curcio CA, Medeiros NE, Millican CL. Photoreceptor loss in age-related macular degeneration. Investig Ophthalmol Vis Sci. 1996;37:1236–49.

CAS  Google Scholar 

Pondorfer SG, Wintergerst MWM, Zadeh SG, Schultz T, Heinemann M, Holz FG, et al. Association of visual function measures with drusen volume in early stages of age-related macular degeneration. Investig Ophthalmol Vis Sci. 2020;61:55.

Article  Google Scholar 

Midena E, Vujosevic S, Convento E, Manfre’ A, Cavarzeran F, Pilotto E. Microperimetry and fundus autofluorescence in patients with early age-related macular degeneration. Br J Ophthalmol 2007;91:1499–503.

Article  PubMed  PubMed Central  Google Scholar 

Ferris FL, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, et al. Clinical classification of age-related macular degeneration. Ophthalmol. 2013;120:844–51.

Article  Google Scholar 

Garvin MK, Abràmoff MD, Wu X, Russell SR, Burns TL, Sonka M. Automated 3-D intraretinal layer segmentation of macular spectral-domain optical coherence tomography images. IEEE Trans Med Imaging 2009;28:1436–47.

Article  PubMed  PubMed Central  Google Scholar 

Li K, Wu X, Chen DZ, Sonka M. Optimal surface segmentation in volumetric images—a graph-theoretic approach. IEEE Trans Pattern Anal Mach Intell 2006;28:119–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schlegl T, Bogunovic H, Klimscha S, Seeböck P, Sadeghipour A, Gerendas B, et al. Fully Automated Segmentation of Hyperreflective Foci in Optical Coherence Tomography Images. arxiv Prepr. 2018. arXiv:18050327.

Wu Z, Ayton LN, Guymer RH, Luu CD. Intrasession test–retest variability of microperimetry in age-related macular degeneration. Investig Ophthalmol Vis Sci. 2013;54:7378.

Article  Google Scholar 

Vujosevic S, Smolek MK, Lebow KA, Notaroberto N, Pallikaris A, Casciano M. Detection of Macular Function Changes in Early (AREDS 2) and Intermediate (AREDS 3) Age-Related Macular Degeneration. Ophthalmologica 2011;225:155–60.

Article  CAS  PubMed  Google Scholar 

Tepelus TC, Hariri AH, Al-Sheikh M, Sadda SR. Correlation Between Mesopic Retinal Sensitivity and Optical Coherence Tomographic Metrics of the Outer Retina in Patients With Non-Atrophic Dry Age-Related Macular Degeneration. Ophthalmic Surg, Lasers Imaging Retin. 2017;48:312–8.

Article  Google Scholar 

Roh M, Laíns I, Shin HJ, Park DH, Mach S, Vavvas DG, et al. Microperimetry in age-related macular degeneration: association with macular morphology assessed by optical coherence tomography. Br J Ophthalmol 2019;103:1769–76.

PubMed  Google Scholar 

Hartmann KI, Bartsch DU, Cheng L, Kim JS, Gomez ML, Klein H, et al. Scanning laser ophthalmoscope imaging stabilized microperimetry in dry age-related macular degeneration. Retina 2011;31:1323–31.

Article  PubMed  Google Scholar 

Schlanitz FG, Baumann B, Kundi M, Sacu S, Baratsits M, Scheschy U, et al. Drusen volume development over time and its relevance to the course of age-related macular degeneration. Br J Ophthalmol 2017;101:198–203.

Article  PubMed  Google Scholar 

Wightman AJ, Abbott CJ, McGuinness MB, Caruso E, Guymer RH, Luu CD. Presymptomatic retinal sensitivity changes in intermediate age-related macular degeneration associated with new retinal fluid. Transl Vis Sci Technol. 2019;8:3.

Article  PubMed  PubMed Central  Google Scholar 

Wu Z, Cunefare D, Chiu E, Luu CD, Ayton LN, Toth CA, et al. Longitudinal associations between microstructural changes and microperimetry in the early stages of age-related macular degeneration. Investig Ophthalmol Vis Sci. 2016;57:3714–22.

Article  CAS  Google Scholar 

Pfau M, Lindner M, Gliem M, Steinberg JS, Thiele S, Finger RP, et al. Mesopic and dark-adapted two-color fundus-controlled perimetry in patients with cuticular, reticular, and soft drusen. Eye 2018;32:1819–30.

Article  PubMed  PubMed Central  Google Scholar 

Saßmannshausen M, Steinberg JS, Fimmers R, Pfau M, Thiele S, Fleckenstein M, et al. Structure-function analysis in patients with intermediate age-related macular degeneration. Investig Ophthalmol Vis Sci. 2018;59:1599.

Article  Google Scholar 

Pollreisz A, Reiter GS, Bogunovic H, Baumann L, Jakob A, Schlanitz FG, et al. Topographic distribution and progression of soft drusen volume in age-related macular degeneration implicate neurobiology of fovea. Investig Ophthalmol Vis Sci. 2021;62:26.

Article  Google Scholar 

Curcio CA, Sloan KR, Kalina RE, Hendrickson AE. Human photoreceptor topography. J Comp Neurol. 1990;292:497–523.

Article  CAS  PubMed  Google Scholar 

Datlinger F, Wassermann L, Reumueller A, Hajdu D, Steiner I, Salas M, et al. Assessment of detailed photoreceptor structure and retinal sensitivity in diabetic macular ischemia using adaptive optics-OCT and microperimetry. Investig Ophthalmol Vis Sci. 2021;62:1.

Article  Google Scholar 

Reumueller A, Wassermann L, Salas M, Karantonis MG, Sacu S, Georgopoulos M, et al. Morphologic and functional assessment of photoreceptors after macula-off retinal detachment with adaptive-optics OCT and microperimetry. Am J Ophthalmol 2020;214:72–85.

Article  PubMed  Google Scholar 

Tarau I-S, Berlin A, Curcio CA, Ach T. The cytoskeleton of the retinal pigment epithelium: from normal aging to age-related macular degeneration. Int J Mol Sci 2019;20:3578.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ach T, Tolstik E, Messinger JD, Zarubina AV, Heintzmann R, Curcio CA. Lipofuscin redistribution and loss accompanied by cytoskeletal stress in retinal pigment epithelium of eyes with age-related macular degeneration. Investig Ophthalmol Vis Sci. 2015;56:3242–52.

Article  CAS  Google Scholar 

Reiter GS, Hacker V, Told R, Schranz M, Krotka P, Schlanitz FG, et al. Longitudinal changes in quantitative autofluorescence during progression from intermediate to late age-related macular degeneration. Retina 2021;41:1236–41.

CAS  PubMed  Google Scholar 

Schmidt-Erfurth U, Bogunovic H, Grechenig C, Bui P, Fabianska M, Waldstein S, et al. Role of deep learning–quantified hyperreflective foci for the prediction of geographic atrophy progression. Am J Ophthalmol 2020;216:257–70.

Article  PubMed  Google Scholar 

Curcio CA, Zanzottera EC, Ach T, Balaratnasingam C, Freund KB. Activated retinal pigment epithelium, an optical coherence tomography biomarker for progression in age-related macular degeneration. Investig Ophthalmol Vis Sci. 2017;58:BIO211–BIO226.

Google Scholar 

Wu Z, Ayton LN, Luu CD, Guymer RH. Relationship between retinal microstructures on optical coherence tomography and microperimetry in age-related macular degeneration. Ophthalmol. 2014;121:1445–52.

Article  Google Scholar 

Reiter GS, Told R, Schlanitz FG, Baumann L, Schmidt-Erfurth U, Sacu S. Longitudinal association between drusen volume and retinal capillary perfusion in intermediate age-related macular degeneration. Investig Ophthalmol Vis Sci. 2019;60:2503.

Article  Google Scholar 

留言 (0)

沒有登入
gif