1   Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

2   Department of Pharmacotherapy and Outcome Sciences, Virginia Commonwealth University, Richmond, Virginia, United States

,

3   Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

4   Clinical Trial Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran

5   Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran

,

Hooman Bakhshandeh

3   Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

4   Clinical Trial Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran

,

Babak Sharif-Kashani

6   Tobacoo Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

7   Department of Cardiology, Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

,

Farid Rashidi

8   Tuberclosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

,

Mohammad Taghi Beigmohammadi

9   Department of Intensive Care, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tehran, Iran

,

Keivan Gohari Moghadam

10   Department of Internal Medicine, School of Medicine, Shariati Hospital, Tehran, Iran

,

Somaye Rezaian

11   Department of Internal Medicine, Alborz University of Medicine Science, Karaj, Iran

,

12   Department of Anesthesiology, School of Medicine Anesthesiology Research Center Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

,

Seyed Hashem Sezavar

13   Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran

,

Mohsen Farrokhpour

14   Department of Internal Medicine, Iran University of Medical Sciences, Firouzgar Hospital, Tehran, Iran

,

Atefeh Abedini

15   Chronic Respiratory Disease Research Center, Shahid Beheshti University of Medical Sciences, Masih Daneshvari Hospital, Tehran, Iran

,

Rasoul Aliannejad

16   Department of Pulmonary and Critical Care, School of Medicine, Shariati Hospital, Tehran, Iran

17   Advanced Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran

,

Taghi Riahi

18   Department of Internal Medicine, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

,

Mahdi Yadollahzadeh

14   Department of Internal Medicine, Iran University of Medical Sciences, Firouzgar Hospital, Tehran, Iran

,

Somayeh Lookzadeh

15   Chronic Respiratory Disease Research Center, Shahid Beheshti University of Medical Sciences, Masih Daneshvari Hospital, Tehran, Iran

,

Parisa Rezaeifar

8   Tuberclosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

,

Samira Matin

8   Tuberclosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

,

Ouria Tahamtan

8   Tuberclosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

,

Keyhan Mohammadi

19   Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

,

Elnaz Zoghi

19   Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

,

Hamid Rahmani

19   Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

,

Seyed Hossein Hosseini

19   Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

,

Seyed Masoud Mousavian

18   Department of Internal Medicine, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

,

Homa Abri

14   Department of Internal Medicine, Iran University of Medical Sciences, Firouzgar Hospital, Tehran, Iran

,

Pardis Sadeghipour

14   Department of Internal Medicine, Iran University of Medical Sciences, Firouzgar Hospital, Tehran, Iran

,

Elahe Baghizadeh

3   Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

,

Farnaz Rafiee

3   Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

,

Sepehr Jamalkhani

20   Student Research Committee, Iran University of Medical Sciences, Tehran, Iran

21   Department of Pharmacotherapy, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tehran, Iran

,

Ahmad Amin

3   Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

,

Bahram Mohebbi

5   Cardiovascular Intervention Research Center, Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran

,

Seyed Ehsan Parhizgar

3   Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

,

Mahshid Soleimanzadeh

12   Department of Anesthesiology, School of Medicine Anesthesiology Research Center Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

,

Maryam Aghakouchakzadeh

19   Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

,

Vahid Eslami

22   Department of Emergency Medicine, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

,

Pooya Payandemehr

23   Department of Emergency Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

,

Hossein Khalili

21   Department of Pharmacotherapy, Tehran University of Medical Sciences, Imam Khomeini Hospital Complex, Tehran, Iran

,

Hamed Talakoob

24   Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran

,

Taranom Tojari

25   Department of Biotechnology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran

,

Shadi Shafaghi

7   Department of Cardiology, Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

,

Sanaz Tabrizi

18   Department of Internal Medicine, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

,

Hessam Kakavand

19   Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

,

Alireza Kashefizadeh

26   Department of Internal Medicine, Shahid Dr. Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

,

Atabak Najafi

22   Department of Emergency Medicine, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

,

27   Respiratory Department, Hospital Ramón y Cajal (IRYCIS), Madrid, Spain

28   Medicine Department, Universidad de Alcalá (IRYCIS), Madrid, Spain

29   CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain

,

Aakriti Gupta

30   Yale/YNHH Center for Outcomes Research and Evaluation (CORE), New Haven, Connecticut, United States

31   Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, California, United States

,

Mahesh V. Madhavan

32   Cardiovascular Research Foundation (CRF), New York, New York, United States

33   Division of Cardiology, Columbia University Irving Medical Center/NewYork-Presbyterian Hospital, New York, New York, United States

,

Sanjum S. Sethi

32   Cardiovascular Research Foundation (CRF), New York, New York, United States

33   Division of Cardiology, Columbia University Irving Medical Center/NewYork-Presbyterian Hospital, New York, New York, United States

,

Sahil A. Parikh

32   Cardiovascular Research Foundation (CRF), New York, New York, United States

33   Division of Cardiology, Columbia University Irving Medical Center/NewYork-Presbyterian Hospital, New York, New York, United States

,

34   Cátedra de Enfermedad Tromboembólica, Universidad Católica de Murcia, Murcia, Spain

,

Naser Hadavand

3   Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

,

Alireza Hajighasemi

1   Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

,

Khalil Ansarin

8   Tuberclosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

,

Majid Maleki

3   Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

,

Saeed Sadeghian

1   Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

,

35   Department of Angiology, University Hospital Zurich, Zurich, Switzerland

36   Center for Thrombosis and Hemostasis, Johannes Gutenberg University Mainz, Mainz, Germany

,

Bob Siegerink

37   Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

,

Erica S. Spatz

38   Yale/YNHH Center for Outcomes Research and Evaluation, New Haven, Connecticut, United States

39   Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, United States

,

40   Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

41   Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

,

Ajay J. Kirtane

40   Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

41   Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

,

Benjamin W. Van Tassell

2   Department of Pharmacotherapy and Outcome Sciences, Virginia Commonwealth University, Richmond, Virginia, United States

,

Gregory Y. H. Lip

42   Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart and Chest Hospital, Liverpool, United Kingdom

43   Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

,

44   Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Centre, Leiden, The Netherlands

,

Samuel Z. Goldhaber

40   Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

41   Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

,

Gregg W. Stone

32   Cardiovascular Research Foundation (CRF), New York, New York, United States

45   The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States

,

Harlan M. Krumholz

30   Yale/YNHH Center for Outcomes Research and Evaluation (CORE), New Haven, Connecticut, United States

39   Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, United States

46   Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut, United States

,

Behnood Bikdeli

32   Cardiovascular Research Foundation (CRF), New York, New York, United States

38   Yale/YNHH Center for Outcomes Research and Evaluation, New Haven, Connecticut, United States

40   Cardiovascular Medicine Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

41   Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States

› Author Affiliations

The study was funded by the Rajaie Cardiovascular Medical and Research Center. Atorvastatin and matching placebo were provided by Sobhan Darou, which is not among the study sponsors. Neither the funder nor the company who donated the study drugs had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript(s) for publication. Dr. Bikdeli is supported by the Scott Schoen and Nancy Adams IGNITE Award from the Mary Horrigan Connors Center for Women's Health and Gender Biology at Brigham and Women's Hospital and a Career Development Award from the American Heart Association and VIVA Physicians (#938814).