4-OI ameliorates bleomycin-induced pulmonary fibrosis by activating Nrf2 and suppressing macrophage-mediated epithelial-mesenchymal transition

Ng B, Dong J, D'Agostino G, Viswanathan S, Widjaja AA, Lim WW, et al. Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis. Sci Transl Med. 2019;11:eaaw1237

Article  Google Scholar 

Richeldi L, Collard HR, Jones MG. Idiopathic pulmonary fibrosis. Lancet. 2017;389:1941–52.

Article  PubMed  Google Scholar 

Taniguchi H, Ebina M, Kondoh Y, Ogura T, Azuma A, Suga M, et al. Pirfenidone in idiopathic pulmonary fibrosis. Eur Respir J. 2010;35:821–9.

Article  CAS  PubMed  Google Scholar 

Crestani B, Huggins JT, Kaye M, Costabel U, Glaspole I, Ogura T, et al. Long-term safety and tolerability of nintedanib in patients with idiopathic pulmonary fibrosis: results from the open-label extension study, INPULSIS-ON. Lancet Respir Med. 2019;7:60–8.

Article  CAS  PubMed  Google Scholar 

Raghu G, Rochwerg B, Zhang Y, Garcia CA, Azuma A, Behr J, et al. An official ATS/ERS/JRS/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis. an update of the 2011 clinical practice guideline. Am J Respir Crit Care Med. 2015;192:e3–19.

Lederer DJ, Martinez FJ. Idiopathic pulmonary fibrosis. N Engl J Med. 2018;378:1811–23.

Article  CAS  PubMed  Google Scholar 

Song Y, Li C, Jin L, Xing J, Sha Z, Zhang T, et al. RIOK2 is negatively regulated by miR-4744 and promotes glioma cell migration/invasion through epithelial-mesenchymal transition. J Cell Mol Med. 2020;24:4494–509.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji Y, Dou YN, Zhao QW, Zhang JZ, Yang Y, Wang T, et al. Paeoniflorin suppresses TGF-beta mediated epithelial-mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway. Acta Pharmacol Sin. 2016;37:794–804.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, Wang Y, Wu G, Xiong W, Gu W, Wang CY. Macrophages: friend or foe in idiopathic pulmonary fibrosis? Respir Res. 2018;19:170.

Article  PubMed  PubMed Central  Google Scholar 

Pechkovsky DV, Prasse A, Kollert F, Engel KM, Dentler J, Luttmann W, et al. Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction. Clin Immunol. 2010;137:89–101.

Article  CAS  PubMed  Google Scholar 

Shapouri-Moghaddam A, Mohammadian S, Vazini H, Taghadosi M, Esmaeili SA, Mardani F, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233:6425–40.

Article  CAS  PubMed  Google Scholar 

Zhu L, Fu X, Chen X, Han X, Dong P. M2 macrophages induce EMT through the TGF-beta/Smad2 signaling pathway. Cell Biol Int. 2017;41:960–8.

Article  CAS  PubMed  Google Scholar 

Olagnier D, Brandtoft AM, Gunderstofte C, Villadsen NL, Krapp C, Thielke AL, et al. Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming. Nat Commun. 2018;9:3506.

Article  PubMed  PubMed Central  Google Scholar 

Liu G, Wu Y, Jin S, Sun J, Wan BB, Zhang J, et al. Itaconate ameliorates methicillin-resistant Staphylococcus aureus-induced acute lung injury through the Nrf2/ARE pathway. Ann Transl Med. 2021;9:712.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li R, Yang W, Yin Y, Ma X, Zhang P, Tao K. 4-OI Attenuates carbon tetrachloride-induced hepatic injury via regulating oxidative stress and the inflammatory response. Front Pharmacol. 2021;12: 651444.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jaiswal AK, Yadav J, Makhija S, Mazumder S, Mitra AK, Suryawanshi A, et al. Irg1/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation. Mucosal Immunol. 2022;15:301–13.

Article  CAS  PubMed  Google Scholar 

Tian F, Wang Z, He J, Zhang Z, Tan N. 4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-beta/Smad pathway, autophagy and reducing generation of reactive oxygen species. Eur J Pharmacol. 2020;873: 172989.

Article  CAS  PubMed  Google Scholar 

Runtsch MC, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, et al. Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages. Cell Metab. 2022;34(487–501): e8.

Google Scholar 

Nie Y, Zhang D, Qian F, Wu Y. Baccatin III ameliorates bleomycin-induced pulmonary fibrosis via suppression of TGF-beta1 production and TGF-beta1-induced fibroblast differentiation. Int Immunopharmacol. 2019;74: 105696.

Article  CAS  PubMed  Google Scholar 

Wu YX, Wang YY, Gao ZQ, Chen D, Liu G, Wan BB, et al. Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway. Acta Pharmacol Sin. 2021;42:2069–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu YX, Jiang FJ, Liu G, Wang YY, Gao ZQ, Jin SH, et al. Dehydrocostus lactone attenuates methicillin-resistant staphylococcus aureus-induced inflammation and acute lung injury via modulating macrophage polarization. Int J Mol Sci. 2021;22(18):9754

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andugulapati SB, Gourishetti K, Tirunavalli SK, Shaikh TB, Sistla R. Biochanin-A ameliorates pulmonary fibrosis by suppressing the TGF-beta mediated EMT, myofibroblasts differentiation and collagen deposition in in vitro and in vivo systems. Phytomedicine. 2020;78: 153298.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Artaud-Macari E, Goven D, Brayer S, Hamimi A, Besnard V, Marchal-Somme J, et al. Nuclear factor erythroid 2-related factor 2 nuclear translocation induces myofibroblastic dedifferentiation in idiopathic pulmonary fibrosis. Antioxid Redox Signal. 2013;18:66–79.

Article  CAS  PubMed  Google Scholar 

Dianat M, Radan M, Badavi M, Mard SA, Bayati V, Ahmadizadeh M. Crocin attenuates cigarette smoke-induced lung injury and cardiac dysfunction by anti-oxidative effects: the role of Nrf2 antioxidant system in preventing oxidative stress. Respir Res. 2018;19:58.

Article  PubMed  PubMed Central  Google Scholar 

Sakai T, Takagaki H, Yamagiwa N, Ui M, Hatta S, Imai J. Effects of the cytoplasm and mitochondrial specific hydroxyl radical scavengers TA293 and mitoTA293 in bleomycin-induced pulmonary fibrosis model mice. Antioxidants. 2021;10(9):1398.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez FJ, Collard HR, Pardo A, Raghu G, Richeldi L, Selman M, et al. Idiopathic pulmonary fibrosis. Nat Rev Dis Prim. 2017;3:17074.

Article  PubMed  Google Scholar 

Miura Y, Ohkubo H, Niimi A, Kanazawa S. Suppression of epithelial abnormalities by nintedanib in induced-rheumatoid arthritis-associated interstitial lung disease mouse model. ERJ Open Res. 2021;7(4):00345-2021.

Article  PubMed  PubMed Central  Google Scholar 

Bao X, Liu X, Liu N, Zhuang S, Yang Q, Ren H, et al. Inhibition of EZH2 prevents acute respiratory distress syndrome (ARDS)-associated pulmonary fibrosis by regulating the macrophage polarization phenotype. Respir Res. 2021;22:194.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ying H, Fang M, Hang QQ, Chen Y, Qian X, Chen M. Pirfenidone modulates macrophage polarization and ameliorates radiation-induced lung fibrosis by inhibiting the TGF-beta1/Smad3 pathway. J Cell Mol Med. 2021;25:8662–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peace CG, O'Neill LA. The role of itaconate in host defense and inflammation. J Clin Investig. 2022;132(2):e148548.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018;556:113–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li R, Yang W, Yin Y, Zhang P, Wang Y, Tao K. Protective role of 4-octyl itaconate in murine LPS/D-GalN-induced acute liver failure via inhibiting inflammation, oxidative stress, and apoptosis. Oxid Med Cell Longev. 2021;2021:9932099.

PubMed  PubMed Central  Google Scholar 

Yi Z, Deng M, Scott MJ, Fu G, Loughran PA, Lei Z, et al. Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in hepatocytes to protect against liver ischemia-reperfusion injury. Hepatology. 2020;72:1394–411.

Article  CAS  PubMed  Google Scholar 

Ogger PP, Albers GJ, Hewitt RJ, O'Sullivan BJ, Powell JE, Calamita E, et al. Itaconate controls the severity of pulmonary fibrosis. Sci Immunol. 2020;5(52):eabc1884.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ke Q, Shi C, Lv Y, Wang L, Luo J, Jiang L, et al. SGLT2 inhibitor counteracts NLRP3 inflammasome via tubular metabolite itaconate in fibrosis kidney. FASEB J. 2022;36: e22078.

Article  CAS  PubMed  Google Scholar 

Fan K, Zan X, Zhi Y, Yang Y, Hu K, Zhang X, et al. Immune response gene 1 deficiency impairs Nrf2 activation and aggravates liver fibrosis in mice. Biochem Biophys Res Commun. 2022;607:103–9.

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