aDepartment of Medicine, Division of Genetic Medicine

bVanderbilt Genetics Institute

cDepartment of Obstetrics and Gynecology, Division of Quantitative Sciences

dDepartment of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee

eDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana

f Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Correspondence to Digna R. Velez Edwards, 2525 West End Ave, Suite 600 6th floor, Nashville, TN 37203, USA. Tel: +1 615 322 1288; e-mail. [email protected]

Abbreviation: BP, blood pressure; DOHaD, developmental origins of health and disease; eQTL, expression quantitative trait loci; FDR, false discovery rate; FUMA, functional mapping and annotation of genome-wide association studies; GPGE, genetically-predicted gene expression; GTEx, genotype-tissue expression project; GWAS, genome-wide association study; HTN, hypertension; LD, linkage disequilibrium; MEGAex, expanded multi-ethnic genotyping array; PP, pulse pressure; PrediXcan, (a gene mapping transcriptome wide analysis) results using; SNP, single nucleotide polymorphism; S-PrediXcan, summary data rather than individual data (S-PrediXcan)

Received 10 October, 2022

Revised 26 January, 2023

Accepted 21 February, 2023

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