These authors contributed equally: Marta Díaz, Laura Campderrós

Pediatric Research Institute Sant Joan de Déu, University of Barcelona, 08950, Esplugues, Barcelona, Spain

Marta Díaz, Laura Campderrós, Francesc Villarroya & Lourdes Ibáñez

Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Health Institute Carlos III, Madrid, Spain

Marta Díaz & Lourdes Ibáñez

Biochemistry and Molecular Biomedicine Department, Biomedicine Institute, University of Barcelona, 08028, Barcelona, Spain

Laura Campderrós, Mariana P. Guimaraes & Francesc Villarroya

Network Biomedical Research Center of Physiopathology of Obesity and Nutrition (CIBEROBN), Health Institute Carlos III, 28029, Madrid, Spain

Laura Campderrós & Francesc Villarroya

Department of Pediatrics, Dr. Josep Trueta Hospital, 17007, Girona, Spain

Abel López-Bermejo

Girona Institute for Biomedical Research, Dr. Josep Trueta Hospital, 17007, Girona, Spain

Abel López-Bermejo

Pediatric & Adolescent Endocrinology, University Hospital Gasthuisberg, 3000, Leuven, Belgium

Francis de Zegher

Department of Development & Regeneration, University of Leuven, 3000, Leuven, Belgium

Francis de Zegher