Abraham J, Janin A, Gornet JM, Peffault de Latour R, Robin M, Xhaard A, de Fontebrune FS, Mary JY, Allez M, Porcher R, Socie G (2014) Clinical severity scores in gastrointestinal graft-versus-host disease. Transplantation 97:965–971. https://doi.org/10.1097/01.TP.0000438209.50089.60

Article  CAS  PubMed  Google Scholar 

Aslanian H, Chander B, Robert M, Cooper D, Proctor D, Seropian S, Jain D (2012) Prospective evaluation of acute graft-versus-host disease. Dig Dis Sci 57:720–725. https://doi.org/10.1007/s10620-011-1938-x

Article  PubMed  Google Scholar 

Beasley TM, Schumacker RE (1995) Multiple Regression Approach to Analyzing Contingency Tables: Post Hoc and Planned Comparison Procedures. J Exp Educ 64:79–93

Article  Google Scholar 

Calmet FH, Yarur AJ, Pukazhendhi G, Ahmad J, Bhamidimarri KR (2015) Endoscopic and histological features of mycophenolate mofetil colitis in patients after solid organ transplantation. Ann Gastroenterol 28:366–373

PubMed  PubMed Central  Google Scholar 

Cardona DM, Detweiler CJ, Shealy MJ, Sung AD, Wild DM, Poleski MH, Balmadrid BL, Cirrincione CT, Howell DN, Sullivan KM (2018) Use of the National Institutes of Health Consensus Guidelines Improves the Diagnostic Sensitivity of Gastrointestinal Graft-Versus-Host Disease. Arch Pathol Lab Med 142:1098–1105. https://doi.org/10.5858/arpa.2017-0054-OA

Article  PubMed  PubMed Central  Google Scholar 

da Costa LNG, Costa-Lima C, de Meirelles LR, Carvalho RB, Colella MP, Aranha FJP, Vigorito AC, De Paula EV (2018) Association between histopathological alterations and diarrhea severity in acute intestinal graft-versus-host disease. Medicine (Baltimore) 97:e0600. https://doi.org/10.1097/MD.0000000000010600

Article  PubMed  Google Scholar 

Daneshpouy M, Socie G, Lemann M, Rivet J, Gluckman E, Janin A (2002) Activated eosinophils in upper gastrointestinal tract of patients with graft-versus-host disease. Blood 99:3033–3040. https://doi.org/10.1182/blood.v99.8.3033

Article  CAS  PubMed  Google Scholar 

Farooq A, Gonzalez IA, Byrnes K, Jenkins SM, Hartley CP, Hagen CE (2022) Multi-institutional development and validation of a novel histologic grading system for colonic graft-versus-host disease. Mod Pathol 35:1254–1261. https://doi.org/10.1038/s41379-022-01065-z

Article  PubMed  Google Scholar 

Ferrara JL, Harris AC, Greenson JK, Braun TM, Holler E, Teshima T, Levine JE, Choi SW, Huber E, Landfried K, Akashi K, Vander Lugt M, Reddy P, Chin A, Zhang Q, Hanash S, Paczesny S (2011) Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease. Blood 118:6702–6708. https://doi.org/10.1182/blood-2011-08-375006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomez AJ, Arai S, Higgins JP, Kambham N (2016) Clinicopathologic Threshold of Acute Colorectal Graft-versus-Host Disease. Arch Pathol Lab Med 140:570–577. https://doi.org/10.5858/arpa.2015-0187-OA

Article  PubMed  Google Scholar 

Harris AC, Young R, Devine S, Hogan WJ, Ayuk F, Bunworasate U, Chanswangphuwana C, Efebera YA, Holler E, Litzow M, Ordemann R, Qayed M, Renteria AS, Reshef R, Wolfl M, Chen YB, Goldstein S, Jagasia M, Locatelli F, Mielke S, Porter D, Schechter T, Shekhovtsova Z, Ferrara JL, Levine JE (2016) International, Multicenter Standardization of Acute Graft-versus-Host Disease Clinical Data Collection: A Report from the Mount Sinai Acute GVHD International Consortium. Biol Blood Marrow Transplant 22:4–10. https://doi.org/10.1016/j.bbmt.2015.09.001

Article  PubMed  Google Scholar 

Im JS, Abraham SC, Saliba RM, Rondon G, Ross WA, Rashid A, Shpall EJ, Popat U, Qazilbash MH, Hosing C, Oran B, Shah N, Tewari P, Nieto Y, Kebriaei P, Champlin RE, Alousi AM (2017) Histologic Grade 1 Is Associated With Increased Nonrelapsed Mortality in Lower Gastrointestinal Graft Versus Host Disease. Am J Surg Pathol 41:1483–1490. https://doi.org/10.1097/PAS.0000000000000914

Article  PubMed  PubMed Central  Google Scholar 

Kreft A, Hippe K, Wagner-Drouet EM, Ries I, Kandulski A, Buttner-Herold M, Neumann H, Weber D, Holler E, Schindeldecker M (2021) An investigation of the diagnostic, predictive, and prognostic impacts of three colonic biopsy grading systems for acute graft versus host disease. PLoS One 16:e0256543. https://doi.org/10.1371/journal.pone.0256543

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kreft A, Mottok A, Mesteri I, Cardona DM, Janin A, Kuhl AA, Andrulis M, Brunner A, Shulman HM, Negri G, Tzankov A, Huber E, Gastrointestinal Pathology Group of the German-Austrian-Swiss Gv HDC (2015) Consensus diagnostic histopathological criteria for acute gastrointestinal graft versus host disease improve interobserver reproducibility. Virchows Arch 467:255-263. https://doi.org/10.1007/s00428-015-1803-y

Lee FD (1993) Importance of apoptosis in the histopathology of drug related lesions in the large intestine. J Clin Pathol 46:118–122. https://doi.org/10.1136/jcp.46.2.118

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lerner KG, Kao GF, Storb R, Buckner CD, Clift RA, Thomas ED (1974) Histopathology of graft-vs.-host reaction (GvHR) in human recipients of marrow from HL-A-matched sibling donors. Transplant Proc 6:367–371

CAS  PubMed  Google Scholar 

Lin J, Fan R, Zhao Z, Cummings OW, Chen S (2013) Is the presence of 6 or fewer crypt apoptotic bodies sufficient for diagnosis of graft versus host disease? A decade of experience at a single institution. Am J Surg Pathol 37:539–547. https://doi.org/10.1097/PAS.0b013e318272c62a

Article  PubMed  Google Scholar 

Ma C, Maluf HM, Liu TC (2015) Acute graft-versus-host disease is more prevalent and severe in the lower than the upper gastrointestinal tract. Hum Pathol 46:1480–1487. https://doi.org/10.1016/j.humpath.2015.06.005

Article  PubMed  Google Scholar 

Melson J, Jakate S, Fung H, Arai S, Keshavarzian A (2007) Crypt loss is a marker of clinical severity of acute gastrointestinal graft-versus-host disease. Am J Hematol 82:881–886. https://doi.org/10.1002/ajh.20976

Article  PubMed  Google Scholar 

Myerson D, Steinbach G, Gooley TA, Shulman HM (2017) Graft-versus-Host Disease of the Gut: A Histologic Activity Grading System and Validation. Biol Blood Marrow Transplant 23:1573–1579. https://doi.org/10.1016/j.bbmt.2017.05.017

Article  PubMed  PubMed Central  Google Scholar 

Nguyen CV, Kastenberg DM, Choudhary C, Katz LC, DiMarino A, Palazzo JP (2008) Is single-cell apoptosis sufficient for the diagnosis of graft-versus-host disease in the colon? Dig Dis Sci 53:747–756. https://doi.org/10.1007/s10620-007-9904-3

Article  PubMed  Google Scholar 

Papadimitriou JC, Drachenberg CB, Beskow CO, Cangro C, Wiland A, Klassen D, Weir M, Bartlett S (2001) Graft-versus-host disease-like features in mycophenolate mofetil-related colitis. Transplant Proc 33:2237–2238. https://doi.org/10.1016/s0041-1345(01)01951-0

Article  CAS  PubMed  Google Scholar 

Riddell RH, Goldman H, Ransohoff DF, Appelman HD, Fenoglio CM, Haggitt RC, Ahren C, Correa P, Hamilton SR, Morson BC et al (1983) Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol 14:931–968. https://doi.org/10.1016/s0046-8177(83)80175-0

Article  CAS  PubMed  Google Scholar 

Sale GE, Shulman HM, McDonald GB, Thomas ED (1979) Gastrointestinal graft-versus-host disease in man. A clinicopathologic study of the rectal biopsy. Am J Surg Pathol 3:291–299. https://doi.org/10.1097/00000478-197908000-00001

Article  CAS  PubMed  Google Scholar 

Salomao M, Dorritie K, Mapara MY, Sepulveda A (2016) Histopathology of Graft-vs-Host Disease of Gastrointestinal Tract and Liver: An Update. Am J Clin Pathol 145:591–603. https://doi.org/10.1093/ajcp/aqw050

Article  CAS  PubMed  Google Scholar 

Sauvestre F, Belleannee G, Breal C, Mohr C, Fong HI, Cossin S, Tabrizi R, Milpied N, Vigouroux S, Goussot JF, Marty M (2018) Histologic analysis has a prognostical value in colorectal biopsies assessed for suspicion of graft-versus-host disease. Virchows Arch 472:213–220. https://doi.org/10.1007/s00428-017-2272-2

Article  CAS  PubMed  Google Scholar 

Schoemans HM, Lee SJ, Ferrara JL, Wolff D, Levine JE, Schultz KR, Shaw BE, Flowers ME, Ruutu T, Greinix H, Holler E, Basak G, Duarte RF, Pavletic SZ, Party ETCW, the E-NIHCGTF (2018) EBMT-NIH-CIBMTR Task Force position statement on standardized terminology & guidance for graft-versus-host disease assessment. Bone Marrow Transplant 53:1401-1415. https://doi.org/10.1038/s41409-018-0204-7

Scott AP, Tey SK, Butler J, Kennedy GA (2018) Diagnostic Utility of Endoscopy and Biopsy in Suspected Acute Gastrointestinal Graft-versus-Host Disease after Hematopoietic Progenitor Cell Transplantation. Biol Blood Marrow Transplant 24:1294–1298. https://doi.org/10.1016/j.bbmt.2018.01.034

Article  PubMed  Google Scholar 

Selbst MK, Ahrens WA, Robert ME, Friedman A, Proctor DD, Jain D (2009) Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil. Mod Pathol 22:737–743. https://doi.org/10.1038/modpathol.2009.44

Article  CAS  PubMed  Google Scholar 

Shidham VB, Chang CC, Shidham G, Ghazala F, Lindholm PF, Kampalath B, George V, Komorowski R (2003) Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients. BMC Gastroenterol 3:5. https://doi.org/10.1186/1471-230x-3-5

Article  PubMed  PubMed Central  Google Scholar 

Shulman HM, Cardona DM, Greenson JK, Hingorani S, Horn T, Huber E, Kreft A, Longerich T, Morton T, Myerson D, Prieto VG, Rosenberg A, Treister N, Washington K, Ziemer M, Pavletic SZ, Lee SJ, Flowers ME, Schultz KR, Jagasia M, Martin PJ, Vogelsang GB, Kleiner DE (2015) NIH Consensus development project on criteria for clinical trials in chronic graft-versus-host disease: II. The 2014 Pathology Working Group Report. Biol Blood Marrow Transplant 21:589–603. https://doi.org/10.1016/j.bbmt.2014.12.031

Article  PubMed  PubMed Central  Google Scholar 

Socie G, Mary JY, Lemann M, Daneshpouy M, Guardiola P, Meignin V, Ades L, Esperou H, Ribaud P, Devergie A, Gluckman E, Ameisen JC, Janin A (2004) Prognostic value of apoptotic cells and infiltrating neutrophils in graft-versus-host disease of the gastrointestinal tract in humans: TNF and Fas expression. Blood 103:50–57. https://doi.org/10.1182/blood-2003-03-0909

Article  CAS  PubMed  Google Scholar 

Star KV, Ho VT, Wang HH, Odze RD (2013) Histologic features in colon biopsies can discriminate mycophenolate from GVHD-induced colitis. Am J Surg Pathol 37:1319–1328. https://doi.org/10.1097/PAS.0b013e31829ab1ef

Article  PubMed  Google Scholar 

Thompson B, Salzman D, Steinhauer J, Lazenby AJ, Wilcox CM (2006) Prospective endoscopic evaluation for gastrointestinal graft-versus-host disease: determination of the best diagnostic approach. Bone Marrow Transplant 38:371–376. https://doi.org/10.1038/sj.bmt.1705453

Article  CAS  PubMed  Google Scholar 

Wild D, Sung AD, Cardona D, Cirricione C, Sullivan K, Detweiler C, Shealy M, Balmadrid B, Rowes KL, Chao N, Piryani S, Karimabad HM, Martin P, Poleski M (2016) The Diagnostic Yield of Site and Symptom-Based Biopsies for Acute Gastrointestinal Graft-Versus-Host Disease: A 5-Year Retrospective Review. Dig Dis Sci 61:806–813. https://doi.org/10.1007/s10620-015-3938-8