AbdelWahab MA, Abou El Magd SF, Grella CE et al (2018) An examination of motives for tramadol and heroin use in an Egyptian sample. J Addict Dis 37:123–134

Article  PubMed  Google Scholar 

Aghajanian GK, Kogan JH, Moghaddam B (1994) Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study. Brain Res 636(1):126–130

Article  CAS  PubMed  Google Scholar 

Ahmed SH (2004) Addiction as compulsive reward prediction. Science 306:1901–1902

Article  CAS  PubMed  Google Scholar 

Akaoka H, Aston-Jones G (1991) Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory amino acid input. J Neurosci 11.12 (1991):3830–3839

Almela P, Navarro-Zaragoza J, García-Carmona J-A et al (2012) Role of corticotropin-releasing factor (CRF) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (NAc). PLoS ONE 7:e47089

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alvarez-Bagnarol Y, Marchette RC, Francis C, Morales M, Vendruscolo LF (2022) Neuronal correlates of hyperalgesia and somatic signs of heroin withdrawal in male and female mice. Eneuro 9(4)

Ambroggi F, Ishikawa A, Fields HL, Nicola SM (2008) Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons. Neuron 59:648–661

Article  CAS  PubMed  PubMed Central  Google Scholar 

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). https://doi.org/10.1176/appi.books.9780890425596

Aston-Jones G, Delfs JM, Druhan J, Zhu Y (1999) The bed nucleus of the stria terminalis. A target site for noradrenergic actions in opiate withdrawal. Ann N Y Acad Sci 877:486–498

Article  CAS  PubMed  Google Scholar 

Azizi H, Mirnajafi-Zadeh J, Rohampour K, Semnanian S (2010) Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats. Neurosci Lett 482:255–259

Article  CAS  PubMed  Google Scholar 

Bagley EE, Chieng BCH, Christie MJ, Connor M (2005) Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine. Br J Pharmacol 146:68–76

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bagley EE, Hacker J, Chefer VI et al (2011) Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors. Nat Neurosci 14:1548–1554

Article  CAS  PubMed  Google Scholar 

Baidoo N, Wolter M, Holahan MR et al (2021) The effects of morphine withdrawal and conditioned withdrawal on memory consolidation and c-Fos expression in the central amygdala. Addict Biol 26:e12909

Article  CAS  PubMed  Google Scholar 

Bajo M, Madamba SG, Roberto M, Siggins GR (2014) Acute morphine alters GABAergic transmission in the central amygdala during naloxone-precipitated morphine withdrawal: role of cyclic AMP. Front Integr Neurosci 8:45

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ballantyne JC, Sullivan MD, Koob GF (2019) Refractory dependence on opioid analgesics. Pain 160:2655–2660

Article  CAS  PubMed  Google Scholar 

Baumgartner HM, Schulkin J, Berridge KC (2021) Activating corticotropin-releasing factor systems in the nucleus accumbens, amygdala, and bed nucleus of stria terminalis: incentive motivation or aversive motivation? Biol Psychiatry 89:1162–1175

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bell J, Strang J (2020) Medication treatment of opioid use disorder. Biol Psychiat 87(1):82–88

Article  CAS  PubMed  Google Scholar 

Benavides M, Laorden ML, García-Borrón JC, Milanés MV (2003) Regulation of tyrosine hydroxylase levels and activity and Fos expression during opioid withdrawal in the hypothalamic PVN and medulla oblongata catecholaminergic cell groups innervating the PVN. Eur J Neurosci 17:103–112

Article  PubMed  Google Scholar 

Berke JD (2018) What does dopamine mean? Nat Neurosci 21:787–793

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bianchetti A, Guidice A, Nava F, Manara L (1986) Dissociation of morphine withdrawal diarrhea and jumping in mice by the peripherally selective opioid antagonist SR 58002 C. Life Sci 39:2297–2303

Article  CAS  PubMed  Google Scholar 

Bobzean SAM, Kokane SS, Butler BD, Perrotti LI (2019) Sex differences in the expression of morphine withdrawal symptoms and associated activity in the tail of the ventral tegmental area. Neurosci Lett 705:124–130

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bonci A, Williams JT (1997) Increased probability of GABA release during withdrawal from morphine. J Neurosci 17:796–803

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bosse GD, Cadeddu R, Floris G, Farero RD, Vigato E, Lee SJ, ... & Peterson RT (2021) The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder. J Clin Invest 131(10)

Bossert JM, Hoots JK, Fredriksson I et al (2019) Role of mu, but not delta or kappa, opioid receptors in context-induced reinstatement of oxycodone seeking. Eur J Neurosci 50:2075–2085

Article  PubMed  Google Scholar 

Bossert JM, Townsend EA, Altidor LK-P, Fredriksson I, Shekara A, Husbands S, et al (2022) Sex differences in the effect of chronic delivery of the buprenorphine analogue BU08028 on heroin relapse and choice in a rat model of opioid maintenance. Br J Pharmacol 179:227–241

Boulos LJ, Ben Hamida S, Bailly J et al (2020) Mu opioid receptors in the medial habenula contribute to naloxone aversion. Neuropsychopharmacology 45:247–255

Article  CAS  PubMed  Google Scholar 

Bradley BP, Gossop M, Phillips GT, Legarda JJ (1987) The development of an opiate withdrawal scale (OWS). Br J Addict 82:1139–1142

Article  CAS  PubMed  Google Scholar 

Brownstein MJ, Palkovits M (1984) Classical transmitters in the CNS, Pt 1. Handbook of Chem Neuroanatomy 2:23–54

Google Scholar 

Bruijnzeel AW (2009) kappa-Opioid receptor signaling and brain reward function. Brain Res Rev 62:127–146

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bruneau A, Frimerman L, Verner M et al (2021) Day-to-day opioid withdrawal symptoms, psychological distress, and opioid craving in patients with chronic pain prescribed opioid therapy. Drug Alcohol Depend 225:108787

Article  CAS  PubMed  Google Scholar 

Cabral A, Ruggiero RN, Nobre MJ et al (2009) GABA and opioid mechanisms of the central amygdala underlie the withdrawal-potentiated startle from acute morphine. Prog Neuropsychopharmacol Biol Psychiatry 33:334–344

Article  CAS  PubMed  Google Scholar 

Cai Y-Q, Hou Y-Y, Pan ZZ (2020) GluA1 in central amygdala increases pain but inhibits opioid withdrawal-induced aversion. Mol Pain 16:1744806920911543

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caillé S, Espejo EF, Reneric J-P et al (1999) Total neurochemical lesion of noradrenergic neurons of the locus ceruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal. J Pharmacol Exp Ther 290:881–892

PubMed  Google Scholar 

Carlezon WA Jr, Thomas MJ (2009) Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis. Neuropharmacology 56(Suppl 1):122–132

Article  CAS  PubMed  Google Scholar 

Carrera MR, Schulteis G, Koob GF (1999) Heroin self-administration in dependent Wistar rats: increased sensitivity to naloxone. Psychopharmacology 144:111–120

Article  CAS  PubMed  Google Scholar 

Centers for Disease Control and Prevention (2022) U.S. overdose deaths in 2021 increased half as much as in 2020 — but are still up 15%. Centers for Disease Control and Prevention. https://www.cdc.gov/nchs/pressroom/nchs_press_releases/2022/202205.htm

Chakrabarti S, Prather PL, Yu L et al (1995) Expression of the μ-opioid receptor in CHO cells: Ability of μ-opioid ligands to promote α-azidoanilido[32P]GTP labeling of multiple G protein α subunits. J Neurochem 64:2534–2543

Article  CAS  PubMed  Google Scholar 

Chan P, Lutfy K (2016) Molecular changes in opioid addiction: the role of adenylyl cyclase and cAMP/PKA system. Prog Mol Biol Transl Sci 137:203–227

Article  PubMed  Google Scholar 

Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA (2003) Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitro. Ann N Y Acad Sci 1003:368–371

Article  PubMed  Google Scholar 

Chartoff EH, Mague SD, Barhight MF et al (2006) Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. J Neurosci 26:6450–6457

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chartoff EH, Barhight MF, Mague SD et al (2009) Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats. Psychopharmacology 204:227–239

Article  CAS  PubMed  PubMed Central  Google Scholar