Bisphenol F (BPF) and its derivatives bear a wide range of application in plastic, coating and other important chemical industries. However, the parallel-consecutive reaction feature makes the bisphenol F synthesis much more complicated and difficult to control. Precise process control is the key to a safer, higher efficient and qualified industrial production. Herein, an in-situ BPF synthesis monitoring technology based on ATR-IR and Raman spectroscopy was established for the first time. With quantitative univariate models, the mechanism and reaction kinetics were studied in depth. Moreover, a better process route with relatively low phenol/formaldehyde ratio has been optimized with the established in-situ monitoring technology, which was promising to be used in the practical industry for a much more sustainable scale-production. The present work enlightened the application of in-situ spectroscopic technologies in practical chemical and pharmaceutical industries.

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