A. Vallelunga and T. Iannitti contributed equally to the paper.

Department of Life Sciences and Biotechnologies, Section of Medicines and Health Products, University of Ferrara, Ferrara, Italy

A. Vallelunga

Department of Medical Sciences, Section of Experimental Medicine, University of Ferrara, Ferrara, Italy

T. Iannitti

Department of Medicine Surgery and Dentistry “Scuola Medica Salernitana”, Neuroscience Section, University of Salerno, Fisciano, Italy

G. Somma, M. C. Russillo, M. Picillo, M. Amboni, P. Barone & M. T. Pellecchia

Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy

R. De Micco & A. Tessitore

IRCCS San Raffaele, Rome, Italy

L. Vacca, A. De Rosa & F. Stocchi

Department of Clinical Neurosciences, Parkinson and Movement Disorders Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

R. Cilia & R. Eleopra

Neurologic Unit, AOU “Policlinico-San Marco”, Department of Medical, Surgical Sciences and Advanced Technologies, GF Ingrassia, University of Catania, Catania, Italy

C. E. Cicero & A. Nicoletti

Parkinson’s Disease and Movement Disorders Unit, IRCCS Mondino Foundation, Pavia, Italy

R. Zangaglia & C. Pacchetti

IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurology Unit, Milan, Italy

G. Lazzeri & A. Di Fonzo

IRCCS San Raffaele Scientific Institute, Neurology Unit, Milan, Italy

S. Galantucci & M. A. Volontè

Department of Neurosciences and Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy

A. De Rosa

IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy

C. Scaglione

University San Raffaele, Roma, Italy

F. Stocchi