Keywords
Idiopathic pulmonary fibrosis
Amino acid metabolism
Lipid metabolism
Carbohydrate metabolism
TCA cycle
Therapeutic targets
AbbreviationsADMA
Asymmetric dimethylarginine
AMPK
AMP- activated protein kinase
ATF
Activating transcription factor
ATI
Alveolar epithelial type I cells
ATII
Alveolar epithelial type II cells
ATP
Adenosine triphosphate
BAL
Bronchioalveolar lavage
BALF
Bronchioalveolar lavage fluid
CAD
Cis-aconitate decarboxylase
Cebpb
CCAAT enhancer binding protein
DDAH
Dimethylarginine dimethylaminohydrolase
Erb2
Receptor tyrosine kinase 2
Fgf
Fibroblast growth factor
H4K16Ac
Histone H4 lysine16 acetylation
hBMSCs
Human bone marrow stromal cells
HDAC8
Histone deacetylase 8
HIF-1α
Hypoxia inducible factor-1 alpha
IM
Interstitial macrophage
IPF
Idiopathic pulmonary fibrosis
mTOR
Mammalian target of rapamycin
NAD
Nicotinamide adenine dinucleotide
NETs
Neutrophil extracellular traps
PDGFR
Platelet-derived growth factor receptor
PFS
Progression free survival
PGDF
Platelet derived growth factor
PHGDH
Phosphoglycerate dehydrogenase
PI3K
Phosphoinositide kinase 3
PPAR
Peroxisome proliferator-activated receptor
ROS
Reactive oxygen species
S1P
Sphingosine 1-phosphate
SDH
Succinate dehydrogenase
SHMT2
Hydroxymethyltransferase
SMAD
Suppressor of mothers against decapentaplegic
SUCNR1
Succinate receptor 1
TAZ
WW domain containing transcription regulator 1
TGF-β
Transforming growth factor-beta
Timp2
Tissue inhibitor of metalloproteases 2
VEGF
Vascular endothelial growth factor
XIAP
X-linked inhibitor of apoptosis
YAP
Yes associated protein
α-SMA
alpha smooth muscle actin
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