Preparation, characterization, and evaluation of the antitumor effect of kaempferol nanosuspensions

Chandra RA, Keane FK, Voncken FEM, Thomas CR. Contemporary radiotherapy: present and future. Lancet. 2021;398:171–84.

Article  PubMed  Google Scholar 

Zheng P-P, Li J, Kros JM. Breakthroughs in modern cancer therapy and elusive cardiotoxicity: critical research-practice gaps, challenges, and insights. Med Res Rev. 2018;38:325–76.

Article  CAS  PubMed  Google Scholar 

Li B, Shao H, Gao L, Li H, Sheng H, Zhu L. Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review. Drug Deliv. 2022;29:2130–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu H, Jiapaer Z, Meng F, Wu W, Hou C, Duan M, et al. Construction of high loading natural active substances nanoplatform and application in synergistic tumor therapy. IJN. 2022;17:2647–59.

Article  PubMed  PubMed Central  Google Scholar 

Mao Q-Q, Xu X-Y, Shang A, Gan R-Y, Wu D-T, Atanasov AG, et al. Phytochemicals for the prevention and treatment of gastric cancer: effects and mechanisms. IJMS. 2020;21:570.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muhammad N, Usmani D, Tarique M, Naz H, Ashraf M, Raliya R, et al. The role of natural products and their multitargeted approach to treat solid cancer. Cells. 2022;11:2209.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang L, Gao Y, Bajpai VK, El-Kammar HA, Simal-Gandara J, Cao H, et al. Advance toward isolation, extraction, metabolism and health benefits of kaempferol, a major dietary flavonoid with future perspectives. Crit Rev Food Sci Nutr. 2021;1–17.

Imran M, Salehi B, Sharifi-Rad J, Aslam Gondal T, Saeed F, Imran A, et al. Kaempferol: a key emphasis to its anticancer potential. Molecules. 2019;24:2277.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Wang R, Hu H, Chen X, Yin Z, Liang X, et al. The antiviral activity of kaempferol against pseudorabies virus in mice. BMC Vet Res. 2021;17:247.

Article  PubMed  PubMed Central  Google Scholar 

Sharma N, Biswas S, Al-Dayan N, Alhegaili AS, Sarwat M. Antioxidant role of kaempferol in prevention of hepatocellular carcinoma. Antioxidants. 2021;10:1419.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu P, Meng X, Zheng H, Zeng Q, Chen T, Wang W, et al. Kaempferol attenuates ROS-induced hemolysis and the molecular mechanism of its induction of apoptosis on bladder cancer. Molecules. 2018;23:2592.

Article  PubMed  PubMed Central  Google Scholar 

Yang G, Xing J, Aikemu B, Sun J, Zheng M. Kaempferol exhibits a synergistic effect with doxorubicin to inhibit proliferation, migration, and invasion of liver cancer. Oncol Rep. 2021;45:32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo H, Rankin GO, Li Z, DePriest L, Chen YC. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem. 2011;128:513–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Da J, Xu M, Wang Y, Li W, Lu M, Wang Z. Kaempferol promotes apoptosis while inhibiting cell proliferation via androgen-dependent pathway and suppressing vasculogenic mimicry and invasion in prostate cancer. Anal Cell Pathol. 2019;2019:1–10.

Article  Google Scholar 

Nandi SK, Pradhan A, Das B, Das B, Basu S, Mallick B, et al. Kaempferol attenuates viability of ex-vivo cultured post-NACT breast tumor explants through downregulation of p53 induced stemness, inflammation and apoptosis evasion pathways. Pathol - Res Pract. 2022;237:154029.

Felice MR, Maugeri A, De Sarro G, Navarra M, Barreca D. Molecular pathways involved in the anti-cancer activity of flavonols: a focus on myricetin and kaempferol. IJMS. 2022;23:4411.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin Y, Zhai Z, Jia H, Lai J, Si X, Wu Z. Kaempferol attenuates diquat-induced oxidative damage and apoptosis in intestinal porcine epithelial cells. Food Funct. 2021;12:6889–99.

Article  CAS  PubMed  Google Scholar 

Bian Y, Lei J, Zhong J, Wang B, Wan Y, Li J, et al. Kaempferol reduces obesity, prevents intestinal inflammation, and modulates gut microbiota in high-fat diet mice. J Nutr Biochem. 2022;99:108840.

Arabyan E, Hakobyan A, Hakobyan T, Grigoryan R, Izmailyan R, Avetisyan A, et al. Flavonoid library screening reveals kaempferol as a potential antiviral agent against African swine fever virus. Front Microbiol. 2021;12:736780.

Özkütük AS. Antimicrobial effects of carnosic acid, kaempferol and luteolin on biogenic amine production by spoilage and food-borne pathogenic bacteria. Food Biosci. 2022;46:101588.

Yang W, Xie D, Liang Y, Chen N, Xiao B, Duan L, et al. Multi-responsive fibroin-based nanoparticles enhance anti-inflammatory activity of kaempferol. J Drug Deliv Sci Technol. 2022;68:103025.

Article  CAS  Google Scholar 

Chen C, Zhang Y, Chen Z, Yang H, Gu Z. Cellular transformers for targeted therapy. Adv Drug Deliv Rev. 2021;179:114032.

Li S, Wu Y, Liu S, Wu T, Liu G, Li T, et al. A multifunctional platinum( iv ) and cyanine dye-based polyprodrug for trimodal imaging-guided chemo–phototherapy. J Mater Chem B. 2022;10:1031–41.

Article  CAS  PubMed  Google Scholar 

Chen Z, Li H, Bian Y, Wang Z, Chen G, Zhang X, et al. Bioorthogonal catalytic patch. Nat Nanotechnol. 2021;16:933–41.

Article  CAS  PubMed  Google Scholar 

Wang T, Zhang D, Sun D, Gu J. Current status of in vivo bioanalysis of nano drug delivery systems. J Pharm Anal. 2020;10:221–32.

Article  PubMed  PubMed Central  Google Scholar 

Xu R, Jiang C, Zhou L, Li B, Hu Y, Guo Y, et al. Fabrication of stable apigenin nanosuspension with PEG 400 as antisolvent for enhancing the solubility and bioavailability. AAPS PharmSciTech. 2022;23:12.

Article  CAS  Google Scholar 

Zhang T, Li X, Xu J, Shao J, Ding M, Shi S. Preparation, characterization, and evaluation of breviscapine nanosuspension and its freeze-dried powder. Pharmaceutics. 2022;14:923.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ao H, Li Y, Li H, Wang Y, Han M, Guo Y, et al. Preparation of hydroxy genkwanin nanosuspensions and their enhanced antitumor efficacy against breast cancer. Drug Deliv. 2020;27:816–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elbaz NM, Tatham LM, Owen A, Rannard S, McDonald TO. Redispersible nanosuspensions as a plausible oral delivery system for curcumin. Food Hydrocoll. 2021;121:107005.

Article  CAS  Google Scholar 

Na Y-G, Pham TMA, Byeon J-J, Kim M-K, Han M-G, Baek J-S, et al. Development and evaluation of TPGS/PVA-based nanosuspension for enhancing dissolution and oral bioavailability of ticagrelor. Int J Pharm. 2020;581:119287.

Qiao Y, Cao Y, Yu K, Zong L, Pu X. Preparation and antitumor evaluation of quercetin nanosuspensions with synergistic efficacy and regulating immunity. Int J Pharm. 2020;589:119830.

Tao X, Shi H, Cao A, Cai L. Influence of polyphenol-metal ion-coated ovalbumin/sodium alginate composite nanoparticles on the encapsulation of kaempferol/tannin acid. Int J Biol Macromol. 2022;209:1288–97.

Article  CAS  PubMed  Google Scholar 

Gupta N, Kamath S M, Rao SK, D J, Patil S, Gupta N, et al. Kaempferol loaded albumin nanoparticles and dexamethasone encapsulation into electrospun polycaprolactone fibrous mat – concurrent release for cartilage regeneration. J Drug Deliv Sci Technol. 2021;64:102666.

Kazmi I, Al-Abbasi FA, Afzal M, Altayb HN, Nadeem MS, Gupta G. Formulation and evaluation of kaempferol loaded nanoparticles against experimentally induced hepatocellular carcinoma: in vitro and in vivo studies. Pharmaceutics. 2021;13:2086.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Y, Liu J, Cui X, Hou J, Yu F, Wang J, et al. Hyaluronic acid modified nanostructured lipid carrier for targeting delivery of kaempferol to NSCLC: preparation, optimization, characterization, and performance evaluation in vitro. Molecules. 2022;27:4553.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haeri V, Karimi E, Oskoueian E. Synthesized nanoliposome‐encapsulated kaempferol attenuates liver health parameters and gene expression in mice challenged by cadmium‐induced toxicity. Biotech App Biochem. 2022;bab.2368.

S Qian Y, Ramamurthy S, Candasamy M, Md S, H Kumar R, S Meka V. Production, characterization and evaluation of kaempferol nanosuspension for improving oral bioavailability. CPB. 2016;17:549–55.

Mohammad IS, Hu H, Yin L, He W. Drug nanocrystals: fabrication methods and promising therapeutic applications. Int J Pharm. 2019;562:187–202.

Article  CAS  PubMed  Google Scholar 

Li H, Li M, Fu J, Ao H, Wang W, Wang X. Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions. Drug Deliv. 2021;28:1226–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xue X, Liu H, Wang S, Hu Y, Huang B, Li M, et al. Neutrophil-erythrocyte hybrid membrane-coated hollow copper sulfide nanoparticles for targeted and photothermal/anti-inflammatory therapy of osteoarthritis. Compos B Eng. 2022;237:109855.

Sawant SS, Patil SM, Shukla SK, Kulkarni NS, Gupta V, Kunda NK. Pulmonary delivery of osimertinib liposomes for non-small cell lung cancer treatment: formulation development and in vitro evaluation. Drug Deliv Transl Res. 2022;12:2474–87.

Article  CAS  PubMed  Google Scholar 

Zhang J, Yin X, Li C, Yin X, Xue Q, Ding L, et al. A multifunctional photoacoustic/fluorescence dual-mode-imaging gold-based theranostic nanoformulation without external laser limitations. Adv Mater. 2022;34:2110690.

Article  CAS  Google Scholar 

Danaei M, Dehghankhold M, Ataei S, Hasanzadeh Davarani F, Javanmard R, Dokhani A, et al. Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics. 2018;10:57.

Article  PubMed  PubMed Central  Google Scholar 

Chen H, Deng M, Xie L, Liu K, Zhang X, Li X. Preparation and characterization of quercetin nanosuspensions using gypenosides as novel stabilizers. J Drug Deliv Sci Technol. 2022;67:102962.

Article  CAS  Google Scholar 

Chen X, Gu J, Sun L, Li W, Guo L, Gu Z, et al. Efficient drug delivery and anticancer effect of micelles based on vitamin E succinate and chitosan derivatives. Bioact Mater. 2021;6:3025–35.

Article  CAS 

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