Ellagic acid and its metabolites urolithins A/B ameliorate most common disease phenotypes in cellular and mouse models for lysosomal storage disorders by enhancing extracellular vesicle secretion

Keywords

Extracellular vesicles

Polyphenols

Lysosomal storage disorders

Niemann pick

Brain

AbbreviationsASMko

acid sphingomyelinase knock out mouse

BMDM

bone marrow-derived macrophages

dhSM

dihydro sphingomyelin

ECV

extracellular microvesicles/exosomes

LC/MS

liquid chromatography and mass spectrometry

LPC

lysophosphatidylcholine

LSDs

lysosomal storage disorders

MES

morpholinoethanesulfonic acid

MVBs

multivesicular bodies

NPDA

Niemann Pick disease type A

NPDC

Niemann Pick disease type C

PE

phosphatidylethanolamine

Data availability

No data was used for the research described in the article.

© 2023 Published by Elsevier Inc.

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