Cells Resident to Precision Templated 40-µm Pore Scaffolds Generate Small Extracellular Vesicles that Affect CD4+ T Cell Phenotypes Through Regulatory TLR4 Signaling

Unresolved (chronic) inflammation around implanted medical devices leads to reduced vascularization, formation of foreign body giant cells, and collagenous encapsulation (i.e., the foreign body reaction, or FBR). PTS are porous polymer constructs [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14] where every pore is the same size, and pore interconnects are also uniform in size, with both parameters being adjustable. If the pore size is ∼40µm, PTS show no chronic

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