Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.
Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2021;7:6.
Villanueva A. Hepatocellular carcinoma. N Engl J Med. 2019;380:1450–62.
Article CAS PubMed Google Scholar
Vogel A, Cervantes A, Chau I, Daniele B, Llovet JM, Meyer T, et al. Hepatocellular carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29:iv238–55.
Article CAS PubMed Google Scholar
Roderburg C, Wree A, Demir M, Schmelzle M, Tacke F. The role of the innate immune system in the development and treatment of hepatocellular carcinoma. Hepat Oncol. 2020;7:HEP17.
Article PubMed PubMed Central Google Scholar
Ding X, He M, Chan AWH, Song QX, Sze SC, Chen H, et al. Genomic and epigenomic features of primary and recurrent hepatocellular carcinomas. Gastroenterology. 2019;157:1630–45.e6.
Article CAS PubMed Google Scholar
Zheng N, Shabek N. Ubiquitin ligases: structure, function, and regulation. Annu Rev Biochem. 2017;86:129–57.
Article CAS PubMed Google Scholar
Senft D, Qi J, Ronai ZA. Ubiquitin ligases in oncogenic transformation and cancer therapy. Nat Rev Cancer. 2018;18:69–88.
Article CAS PubMed Google Scholar
Bijlmakers MJ, Teixeira JM, Boer R, Mayzel M, Puig-Sàrries P, Karlsson G, et al. A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125. Sci Rep. 2016;6:29232.
Article CAS PubMed PubMed Central Google Scholar
Yang L, Zhou B, Li X, Lu Z, Li W, Huo X, et al. RNF125 is a ubiquitin-protein ligase that promotes p53 degradation. Cell Physiol Biochem. 2015;35:237–45.
Article CAS PubMed Google Scholar
Kim H, Frederick DT, Levesque MP, Cooper ZA, Feng Y, Krepler C, et al. Downregulation of the ubiquitin ligase RNF125 underlies resistance of melanoma cells to BRAF inhibitors via JAK1 deregulation. Cell Rep. 2015;11:1458–73.
Article CAS PubMed PubMed Central Google Scholar
Kodama T, Kodama M, Jenkins NA, Copeland NG, Chen HJ, Wei Z. Ring finger protein 125 is an anti-proliferative tumor suppressor in hepatocellular carcinoma. Cancers (Basel). 2022;14:2589.
Vasuri F, Visani M, Acquaviva G, Brand T, Fiorentino M, Pession A, et al. Role of microRNAs in the main molecular pathways of hepatocellular carcinoma. World J Gastroenterol. 2018;24:2647–60.
Article CAS PubMed PubMed Central Google Scholar
Komoll RM, Hu Q, Olarewaju O, von Döhlen L, Yuan Q, Xie Y, et al. MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma. J Hepatol. 2021;74:122–34.
Article CAS PubMed Google Scholar
Zhang H, Liu A, Feng X, Tian L, Bo W, Wang H, et al. MiR-132 promotes the proliferation, invasion and migration of human pancreatic carcinoma by inhibition of the tumor suppressor gene PTEN. Prog Biophys Mol Biol. 2019;148:65–72.
Article CAS PubMed Google Scholar
Xing S, Tian Z, Zheng W, Yang W, Du N, Gu Y, et al. Hypoxia downregulated miR-4521 suppresses gastric carcinoma progression through regulation of IGF2 and FOXM1. Mol Cancer. 2021;20:9.
Article CAS PubMed PubMed Central Google Scholar
Gao JB, Zhu MN, Zhu XL. miRNA-215-5p suppresses the aggressiveness of breast cancer cells by targeting Sox9. FEBS Open Bio. 2019;9:1957–67.
Article CAS PubMed PubMed Central Google Scholar
Shimoni-Sebag A, Lebenthal-Loinger I, Zender L, Karni R. RRM1 domain of the splicing oncoprotein SRSF1 is required for MEK1-MAPK-ERK activation and cellular transformation. Carcinogenesis. 2013;34:2498–504.
Article CAS PubMed Google Scholar
Das S, Anczuków O, Akerman M, Krainer AR. Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC. Cell Rep. 2012;1:110–7.
Article CAS PubMed PubMed Central Google Scholar
Wang Y, Xiao X, Zhang J, Choudhury R, Robertson A, Li K, et al. A complex network of factors with overlapping affinities represses splicing through intronic elements. Nat Struct Mol Biol. 2013;20:36–45.
Gonçalves V, Jordan P. Posttranscriptional regulation of splicing factor SRSF1 and its role in cancer cell biology. Biomed Res Int. 2015;2015:287048.
Article PubMed PubMed Central Google Scholar
Du JX, Luo YH, Zhang SJ, Wang B, Chen C, Zhu GQ, et al. Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1. J Exp Clin Cancer Res. 2021;40:171.
Article CAS PubMed PubMed Central Google Scholar
De Miguel FJ, Sharma RD, Pajares MJ, Montuenga LM, Rubio A, Pio R. Identification of alternative splicing events regulated by the oncogenic factor SRSF1 in lung cancer. Cancer Res. 2014;74:1105–15.
Wu ZH, Liu CC, Zhou YQ, Hu LN, Guo WJ. OnclncRNA-626 promotes malignancy of gastric cancer via inactivated the p53 pathway through interacting with SRSF1. Am J Cancer Res. 2019;9:2249–63.
CAS PubMed PubMed Central Google Scholar
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7–30.
Yang YM, Kim SY, Seki E. Inflammation and liver cancer: molecular mechanisms and therapeutic targets. Semin Liver Dis. 2019;39:26–42.
Article CAS PubMed PubMed Central Google Scholar
Liu Y, Tao S, Liao L, Li Y, Li H, Li Z, et al. TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. Nat Commun. 2020;11:348.
Article PubMed PubMed Central Google Scholar
Krais JJ, Wang Y, Bernhardy AJ, Clausen E, Miller JA, Cai KQ, et al. RNF168-mediated ubiquitin signaling inhibits the viability of BRCA1-null cancers. Cancer Res. 2020;80:2848–60.
Article CAS PubMed PubMed Central Google Scholar
Chen L, Yuan R, Wen C, Liu T, Feng Q, Deng X, et al. E3 ubiquitin ligase UBR5 promotes pancreatic cancer growth and aerobic glycolysis by downregulating FBP1 via destabilization of C/EBPα. Oncogene. 2021;40:262–76.
Article CAS PubMed Google Scholar
Hammond SM. An overview of microRNAs. Adv Drug Deliv Rev. 2015;87:3–14.
Article CAS PubMed PubMed Central Google Scholar
Yao Q, Chen Y, Zhou X. The roles of microRNAs in epigenetic regulation. Curr Opin Chem Biol. 2019;51:11–17.
Article CAS PubMed Google Scholar
Khan AQ, Ahmed EI, Elareer NR, Junejo K, Steinhoff M, Uddin S. Role of miRNA-regulated cancer stem cells in the pathogenesis of human malignancies. Cells. 2019;8:840.
Article PubMed PubMed Central Google Scholar
Liu Y, Zhang Y, Xiao B, Tang N, Hu J, Liang S, et al. MiR-103a promotes tumour growth and influences glucose metabolism in hepatocellular carcinoma. Cell Death Dis. 2021;12:618.
Article PubMed PubMed Central Google Scholar
Sun Z, Zhang Q, Yuan W, Li X, Chen C, Guo Y, et al. MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis. J Exp Clin Cancer Res. 2020;39:250.
Article CAS PubMed PubMed Central Google Scholar
Zhang J, Lu Q, Pang H, Zhang M, Wei W. MiR-103a-3p aggravates renal cell carcinoma by targeting TMEM33. Am J Transl Res. 2021;13:12694–703.
CAS PubMed PubMed Central Google Scholar
Fan Z, Yang J, Zhang D, Zhang X, Ma X, Kang L, et al. The risk variant rs884225 within EGFR impairs miR-103a-3p’s anti-tumourigenic function in non-small cell lung cancer. Oncogene. 2019;38:2291–304.
留言 (0)