A network map of macrophage-stimulating protein (MSP) signaling

Baird AM, Easty D, Jarzabek M, Shiels L, Soltermann A, Klebe S, Raeppel S, MacDonagh L, Wu C, Griggs K, Kirschner MB, Stanfill B, Nonaka D, Goparaju CM, Murer B, Fennell DA, O’Donnell DM, Barr MP, Mutti L, Reid G, Finn S, Cuffe S, Pass HI, Opitz I, Byrne AT, O’Byrne KJ, Gray SG (2019) When RON MET TAM in mesothelioma: all druggable for one, and one drug for all? Front Endocrinol (lausanne) 10:89

Article  PubMed  Google Scholar 

Brunelleschi S, Penengo L, Lavagno L, Santoro C, Colangelo D, Viano I, Gaudino G (2001) Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin. Br J Pharmacol 134(6):1285–1295

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chanda D, Li T, Song KH, Kim YH, Sim J, Lee CH, Chiang JY, Choi HS (2009) Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. J Biol Chem 284(42):28510–28521

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chanda D, Li J, Oligschlaeger Y, Jeurissen ML, Houben T, Walenbergh SM, Shiri-Sverdlov R, Neumann D (2016) MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis. Exp Mol Med 48(9):e258

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chaudhuri A, Wilson NS, Yang B, Paler Martinez A, Liu J, Zhu C, Bricker N, Couto S, Modrusan Z, French D, Cupp J, Ashkenazi A (2013) Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages. Immunol Cell Biol 91(7):451–460

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cote M, Miller AD, Liu SL (2007) Human RON receptor tyrosine kinase induces complete epithelial-to-mesenchymal transition but causes cellular senescence. Biochem Biophys Res Commun 360(1):219–225

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cunha S, Lin YC, Goossen EA, DeVette CI, Albertella MR, Thomson S, Mulvihill MJ, Welm AL (2014) The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming. Cell Rep 6(1):141–154

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dagamajalu S, Rex DAB, Palollathil A, Shetty R, Bhat G, Cheung LWT, Prasad TSK (2021) Correction to: a pathway map of AXL receptor-mediated signaling network. J Cell Commun Signal 15(1):149

Article  CAS  PubMed  Google Scholar 

Dagamajalu S, Rex DAB, Suchitha GP, Rai AB, Kumar S, Joshi S, Raju R and Prasad TSK (2022) A network map of discoidin domain receptor 1(DDR1)-mediated signaling in pathological conditions J Cell Commun Signal

Danilkovitch A, Skeel A, Leonard EJ (1999) Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism. Exp Cell Res 248(2):575–582

Article  CAS  PubMed  Google Scholar 

Danilkovitch A, Donley S, Skeel A, Leonard EJ (2000) Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells. Mol Cell Biol 20(6):2218–2227

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eyob H, Ekiz HA, Derose YS, Waltz SE, Williams MA, Welm AL (2013) Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity. Cancer Discov 3(7):751–760

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faham N, Zhao L, Welm AL (2018) mTORC1 is a key mediator of RON-dependent breast cancer metastasis with therapeutic potential. NPJ Breast Cancer 4:36

Article  PubMed  PubMed Central  Google Scholar 

Ganesan R, Kolumam GA, Lin SJ, Xie MH, Santell L, Wu TD, Lazarus RA, Chaudhuri A, Kirchhofer D (2011) Proteolytic activation of pro-macrophage-stimulating protein by hepsin. Mol Cancer Res 9(9):1175–1186

Article  CAS  PubMed  Google Scholar 

Gunella G, Bardelli C, Amoruso A, Viano I, Balbo P, Brunelleschi S (2006) Macrophage-stimulating protein differently affects human alveolar macrophages from smoker and non-smoker patients: evaluation of respiratory burst, cytokine release and NF-kappaB pathway. Br J Pharmacol 148(4):478–489

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gurusamy D, Gray JK, Pathrose P, Kulkarni RM, Finkleman FD, Waltz SE (2013) Myeloid-specific expression of Ron receptor kinase promotes prostate tumor growth. Cancer Res 73(6):1752–1763

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han S, Stuart LA, Degen SJ (1991) Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. Biochemistry 30(40):9768–9780

Article  CAS  PubMed  Google Scholar 

Huang L, Fang X, Shi D, Yao S, Wu W, Fang Q, Yao H (2020) MSP-RON Pathway: potential regulator of inflammation and innate immunity. Front Immunol 11:569082

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iwama A, Wang MH, Yamaguchi N, Ohno N, Okano K, Sudo T, Takeya M, Gervais F, Morissette C, Leonard EJ, Suda T (1995) Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the STK protein tyrosine kinase, a receptor for macrophage-stimulating protein. Blood 86(9):3394–3403

Article  CAS  PubMed  Google Scholar 

Iwama A, Yamaguchi N, Suda T (1996) STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. EMBO J 15(21):5866–5875

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeong BC, Oh SH, Lee MN, Koh JT (2020) Macrophage-stimulating protein enhances osteoblastic differentiation via the recepteur d'origine nantais receptor and extracellular signal-regulated kinase signaling pathway. J Bone Metab 27(4):267–279

Article  PubMed  PubMed Central  Google Scholar 

Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A (2010) NetPath: a public resource of curated signal transduction pathways. Genome Biol 11(1):R3

Article  PubMed  PubMed Central  Google Scholar 

Kauder SE, Santell L, Mai E, Wright LY, Luis E, N’Diaye EN, Lutman J, Ratti N, Sa SM, Maun HR, Stefanich E, Gonzalez LC, Graham RR, Diehl L, Faubion WA Jr, Keir ME, Young J, Chaudhuri A, Lazarus RA, Egen JG (2013) Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele. PLoS ONE 8(12):e83958

Article  PubMed  PubMed Central  Google Scholar 

Kretschmann KL, Eyob H, Buys SS, Welm AL (2010) The macrophage stimulating protein/Ron pathway as a potential therapeutic target to impede multiple mechanisms involved in breast cancer progression. Curr Drug Targets 11(9):1157–1168

Article  CAS  PubMed  Google Scholar 

Kutmon M, van Iersel MP, Bohler A, Kelder T, Nunes N, Pico AR, Evelo CT (2015) PathVisio 3: an extendable pathway analysis toolbox. PLoS Comput Biol 11(2):e1004085

Article  PubMed  PubMed Central  Google Scholar 

Leonard EJ, Skeel A (1976) A serum protein that stimulates macrophage movement, chemotaxis and spreading. Exp Cell Res 102(2):434–438

Article  CAS  PubMed  Google Scholar 

Leonard EJ, Skeel AH (1978) Isolation of macrophage stimulating protein (MSP) from human serum. Exp Cell Res 114(1):117–126

Article  CAS  PubMed  Google Scholar 

Ling Y, Kuang Y, Chen LL, Lao WF, Zhu YR, Wang LQ, Wang D (2017) A novel RON splice variant lacking exon 2 activates the PI3K/AKT pathway via PTEN phosphorylation in colorectal carcinoma cells. Oncotarget 8(24):39101–39116

Article  PubMed  PubMed Central  Google Scholar 

Lu T, Wang Z, Prativa S, Xu Y, Wang T, Zhang Y, Yu L, Xu N, Tang J, You W, Chen G, Zhang JH (2019) Macrophage stimulating protein preserves blood brain barrier integrity after intracerebral hemorrhage through recepteur d’origine nantais dependent GAB1/Src/beta-catenin pathway activation in a mouse model. J Neurochem 148(1):114–126

Article  CAS  PubMed  Google Scholar 

Ma Q, Guin S, Padhye SS, Zhou YQ, Zhang RW, Wang MH (2011) Ribosomal protein S6 kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein. Mol Cancer 10:66

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moxley KM, Wang L, Welm AL, Bieniasz M (2016) Short-form Ron is a novel determinant of ovarian cancer initiation and progression. Genes Cancer 7(5–6):169–181

Article  CAS  PubMed  PubMed Central  Google Scholar 

Najar MA, Rex DAB, Modi PK, Agarwal N, Dagamajalu S, Karthikkeyan G, Vijayakumar M, Chatterjee A, Sankar U, Prasad TSK (2021) A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway. J Cell Commun Signal 15(2):283–290

Article  CAS  PubMed  Google Scholar 

Nikolaidis NM, Gray JK, Gurusamy D, Fox W, Stuart WD, Huber N, Waltz SE (2010) Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 production. Shock 33(2):197–204

留言 (0)

沒有登入
gif