Adamiak M, Bujko K, Cymer M, Plonka M, Glaser T, Kucia M, et al. Novel evidence that extracellular nucleotides and purinergic signaling induce innate immunity-mediated mobilization of hematopoietic stem/progenitor cells. Leukemia. 2018;32:1920–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lapidot T, Petit I. Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol. 2002;30:973–81.

Article  CAS  PubMed  Google Scholar 

Nevo N, Zuckerman T, Gur-Cohen S, Kollet O, Avemaria F, Shpall EJ, et al. PAR1 expression predicts clinical G-CSF CD34(+) HSPC mobilization and repopulation potential in transplanted patients. Hemasphere. 2019;3:e288.

Article  PubMed  PubMed Central  Google Scholar 

Roberts AW. G-CSF: a key regulator of neutrophil production, but that’s not all! Growth Factors. 2005;23:33–41.

Article  CAS  PubMed  Google Scholar 

Petit I, Szyper-Kravitz M, Nagler A, Lahav M, Peled A, Habler L, et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol. 2002;3:687–94.

Article  CAS  PubMed  Google Scholar 

Khatib-Massalha E, Bhattacharya S, Massalha H, Biram A, Golan K, Kollet O, et al. Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling. Nat Commun. 2020;11:3547.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caslin HL, Abebayehu D, Pinette JA, Ryan JJ. Lactate is a metabolic mediator that shapes immune cell fate and function. Front Physiol. 2021;12:688485.

Article  PubMed  PubMed Central  Google Scholar 

Wang YH, Israelsen WJ, Lee D, Yu VW, Jeanson NT, Clish CB, et al. Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell 2014;158:1309–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Soto-Heredero G, Gomez de Las Heras MM, Gabande-Rodriguez E, Oller J, Mittelbrunn M. Glycolysis - a key player in the inflammatory response. FEBS J. 2020;287:3350–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Halestrap AP. The monocarboxylate transporter family-Structure and functional characterization. IUBMB Life. 2012;64:1–9.

Article  CAS  PubMed  Google Scholar 

Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chevre R, A-González N, et al. Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell. 2013;153:1025–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ratter JM, Rooijackers HMM, Hooiveld GJ, Hijmans AGM, de Galan BE, Tack CJ, et al. In vitro and in vivo effects of lactate on metabolism and cytokine production of human primary PBMCs and monocytes. Front Immunol. 2018;9:2564.

Article  PubMed  PubMed Central  Google Scholar 

Kozlov AM, Lone A, Betts DH, Cumming RC. Lactate preconditioning promotes a HIF-1alpha-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts. Sci Rep. 2020;10:8388.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Potzsch A, Zocher S, Bernas SN, Leiter O, Runker AE, Kempermann G. L-lactate exerts a pro-proliferative effect on adult hippocampal precursor cells in vitro. iScience. 2021;24:102126.

Article  PubMed  PubMed Central  Google Scholar 

Rabinowitz JD, Enerback S. Lactate: the ugly duckling of energy metabolism. Nat Metab. 2020;2:566–71.

Article  CAS  PubMed  PubMed Central  Google Scholar