Growth differentiation factor 15 (GDF-15) in endocrinology

M.R. Bootcov, A.R. Bauskin, S.M. Valenzuela, A.G. Moore, M. Bansal, X.Y. He, H.P. Zhang, M. Donnellan, S. Mahler, K. Pryor, B.J. Walsh, R.C. Nicholson, W.D. Fairlie, S.B. Por, J.M. Robbins, S.N. Breit, MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc. Natl. Acad. Sci. USA. 94, 11514–11519 (1997)

Article  CAS  PubMed  PubMed Central  Google Scholar 

R. Hromas, M. Hufford, J. Sutton, D. Xu, Y. Li, L. Lu, PLAB, a novel placental bone morphogenetic protein. Biochim. Biophys. Acta. 1354, 40–44 (1997)

Article  CAS  PubMed  Google Scholar 

L.N. Lawton, M.F. Bonaldo, P.C. Jelenc, L. Qiu, S.A. Baumes, R.A. Marcelino, G.M. de Jesus, S. Wellington, J.A. Knowles, D. Warburton, S. Brown, M.B. Soares, Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta. Gene. 203, 17–26 (1997)

Article  CAS  PubMed  Google Scholar 

S.M. Lockhart, V. Saudek, S. O’Rahilly, GDF15: A Hormone Conveying Somatic Distress to the Brain. Endocr. Rev. 41, bnaa007 (2020). https://doi.org/10.1210/endrev/bnaa007

Article  PubMed  PubMed Central  Google Scholar 

A. Assadi, A. Zahabi, R.A. Hart, GDF15, an update of the physiological and pathological roles it plays: a review. Pflugers Arch. 472, 1535–1546 (2020)

Article  CAS  PubMed  Google Scholar 

S.J. Baek, T. Eling, Growth differentiation factor 15 (GDF15): A survival protein with therapeutic potential in metabolic diseases. Pharmacol. Ther. 198, 46–58 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

W.D. Fairlie, A.G. Moore, A.R. Bauskin, P.K. Russell, H.P. Zhang, S.N. Breit, MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation. J. Leukoc. Biol. 65, 2–5 (1999)

Article  CAS  PubMed  Google Scholar 

M. Uhlén, L. Fagerberg, B.M. Hallström, C. Lindskog, P. Oksvold, A. Mardinoglu, Å. Sivertsson, C. Kampf, E. Sjöstedt, A. Asplund, I. Olsson, K. Edlund, E. Lundberg, S. Navani, C.A. Szigyarto, J. Odeberg, D. Djureinovic, J.O. Takanen, S. Hober, T. Alm, P.H. Edqvist, H. Berling, H. Tegel, J. Mulder, J. Rockberg, P. Nilsson, J.M. Schwenk, M. Hamsten, K. von Feilitzen, M. Forsberg, L. Persson, F. Johansson, M. Zwahlen, G. von Heijne, J. Nielsen, F. Pontén, Proteomics. Tissue-based map of the human proteome. Science 347, 1260419 (2015)

Article  PubMed  Google Scholar 

V.W.W. Tsai, Y. Husaini, A. Sainsbury, D.A. Brown, S.N. Breit, The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases. Cell. Metab. 28, 353–368 (2018)

Article  CAS  PubMed  Google Scholar 

T.A. Zimmers, X. Jin, E.C. Hsiao, S.A. McGrath, A.F. Esquela, L.G. Koniaris, Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury. Shock. 23, 543–548 (2005)

CAS  PubMed  Google Scholar 

T.A. Zimmers, X. Jin, E.C. Hsiao, E.A. Perez, R.H. Pierce, K.D. Chavin, L.G. Koniaris, Growth differentiation factor-15: induction in liver injury through p53 and tumor necrosis factor-independent mechanisms. J. Surg. Res. 130, 45–51 (2006)

Article  CAS  PubMed  Google Scholar 

T. Kempf, M. Eden, J. Strelau, M. Naguib, C. Willenbockel, J. Tongers, J. Heineke, D. Kotlarz, J. Xu, J.D. Molkentin, H.W. Niessen, H. Drexler, K.C. Wollert, The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ. Res. 98, 351–360 (2006)

Article  CAS  PubMed  Google Scholar 

H.T. Liu, H.C. Wang, L. Tao, C.X. Li, F. Li, Y.Y. Zhang, B.W. Liu, Stress-induced growth-differentiation factor 15 plays an intriguing role in cardiovascular diseases. Chin. Med. J. (Engl). 126, 1350–1354 (2013)

PubMed  Google Scholar 

J. Wischhusen, I. Melero, W.H. Fridman, Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint. Front. Immunol. 11, 951 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

R. Adela, S.K. Banerjee, GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective. J. Diabetes Res. 2015, 490842 (2015)

Article  PubMed  PubMed Central  Google Scholar 

M. Arkoumani, N. Papadopoulou-Marketou, N.C. Nicolaides, C. Kanaka-Gantenbein, N. Tentolouris, I. Papassotiriou, The clinical impact of growth differentiation factor-15 in heart disease: A 2019 update. Crit. Rev. Clin. Lab. Sci. 57, 114–125 (2020)

Article  CAS  PubMed  Google Scholar 

A.C. Eddy, A.J. Trask, Growth differentiation factor-15 and its role in diabetes and cardiovascular disease. Cytokine Growth Factor Rev. 57, 11–18 (2021)

Article  CAS  PubMed  Google Scholar 

S.H. Lee, J.Y. Lee, K. Lim, Y. Lee, J. Koh, Associations Between Plasma Growth and Differentiation Factor-15 with Aging Phenotypes in Muscle, Adipose Tissue, and Bone. Calcif. Tissue Int. 110, 236–243 (2022)

Article  CAS  PubMed  Google Scholar 

H. Liu, Y. Huang, Y. Lyu, W. Dai, Y. Tong, Y. Li, GDF15 as a biomarker of ageing. Exp. Gerontol. 146, 111228 (2021)

Article  CAS  PubMed  Google Scholar 

H. Johnen, S. Lin, T. Kuffner, D.A. Brown, V.W. Tsai, A.R. Bauskin, L. Wu, G. Pankhurst, L. Jiang, S. Junankar, M. Hunter, W.D. Fairlie, N.J. Lee, R.F. Enriquez, P.A. Baldock, E. Corey, F.S. Apple, M.M. Murakami, E. Lin, C. Wang, M.J. During, A. Sainsbury, H. Herzog, S.N. Breit, Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat. Med. 13, 1333–1340 (2007)

Article  CAS  PubMed  Google Scholar 

V.W. Tsai, L. Macia, H. Johnen, T. Kuffner, R. Manadhar, S.B. Jørgensen, K.K.M. Lee-Ng, H.P. Zhang, L. Wu, C.P. Marquis, L. Jiang, Y. Husaini, S. Lin, H. Herzog, D.A. Brown, A. Sainsbury, S.N. Breit, TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator. PLoS ONE 8, e55174 (2013)

Article  CAS  PubMed  PubMed Central  Google Scholar 

T. Borner, H.S. Wald, M.Y. Ghidewon, B. Zhang, Z. Wu, B.C. De Jonghe, D. Breen, H.J. Grill, GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss. Cell. Rep. 31, 107543 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M. Ghidewon, H.S. Wald, A.D. McKnight, B.C. De Jonghe, D.M. Breen, A.L. Alhadeff, T. Borner, H.J. Grill, Growth differentiation factor 15 (GDF15) and semaglutide inhibit food intake and body weight through largely distinct, additive mechanisms. Diabetes Obes. Metab. 24, 1010–1020 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M. Uhlen, C. Zhang, S. Lee, E. Sjöstedt, L. Fagerberg, G. Bidkhori, R. Benfeitas, M. Arif, Z. Liu, F. Edfors, K. Sanli, K. von Feilitzen, P. Oksvold, E. Lundberg, S. Hober, P. Nilsson, J. Mattsson, J.M. Schwenk, H. Brunnström, B. Glimelius, T. Sjöblom, P. Edqvist, D. Djureinovic, P. Micke, C. Lindskog, A. Mardinoglu, F. Ponten, A pathology atlas of the human cancer transcriptome. Science. 357, eaan2507 (2017). https://doi.org/10.1126/science.aan2507

Article  CAS  PubMed  Google Scholar 

T.E. Eling, S.J. Baek, M. Shim, C.H. Lee, NSAID activated gene (NAG-1), a modulator of tumorigenesis. J. Biochem. Mol. Biol. 39, 649–655 (2006)

CAS  PubMed  Google Scholar 

A.G. Moore, D.A. Brown, W.D. Fairlie, A.R. Bauskin, P.K. Brown, M.L. Munier, P.K. Russell, L.A. Salamonsen, E.M. Wallace, S.N. Breit, The transforming growth factor-ss superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women. J. Clin. Endocrinol. Metab. 85, 4781–4788 (2000)

CAS  PubMed  Google Scholar 

T.M. Michelsen, T. Henriksen, D. Reinhold, T.L. Powell, T. Jansson, The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling. Faseb J. 33, 2944–2956 (2019)

Article  CAS  PubMed  Google Scholar 

U. Andersson-Hall, L. Joelsson, P. Svedin, C. Mallard, A. Holmäng, Growth-differentiation-factor 15 levels in obese and healthy pregnancies: Relation to insulin resistance and insulin secretory function. Clin. Endocrinol. (Oxf). 95, 92–100 (2021)

Article  CAS  PubMed  Google Scholar 

S.N. Breit, H. Johnen, A.D. Cook, V.W. Tsai, M.G. Mohammad, T. Kuffner, H.P. Zhang, C.P. Marquis, L. Jiang, G. Lockwood, M. Lee-Ng, Y. Husaini, L. Wu, J.A. Hamilton, D.A. Brown, The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism. Growth Factors 29, 187–195 (2011)

Article  CAS  PubMed  Google Scholar 

K. Unsicker, B. Spittau, K. Krieglstein, The multiple facets of the TGF-β family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1. Cytokine Growth Factor Rev. 24, 373–384 (2013)

Article  CAS  PubMed  Google Scholar 

J.A. Siddiqui, P. Seshacharyulu, S. Muniyan, R. Pothuraju, P. Khan, R. Vengoji, S. Chaudhary, S.K. Maurya, S.M. Lele, M. Jain, K. Datta, M.W. Nasser, S.K. Batra, GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation. Bone Res. 10, 6-021–00178-6 (2022)

Article  Google Scholar 

J.J. Li, J. Liu, K. Lupino, X. Liu, L. Zhang, L. Pei, Growth Differentiation Factor 15 Maturation Requires Proteolytic Cleavage by PCSK3, -5, and -6. Mol. Cell. Biol. 38, e00249–18 (2018). https://doi.org/10.1128/MCB.00249-18. Print 2018 Nov 1

Article  CAS  PubMed  PubMed Central  Google Scholar 

L. Rochette, M. Zeller, Y. Cottin, C. Vergely, Insights Into Mechanisms of GDF15 and Receptor GFRAL: Therapeutic Targets. Trends Endocrinol. Metab. 31, 939–951 (2020)

Article  CAS  PubMed 

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