GSKIP modulates cell aggregation through EMT/MET signaling rather than differentiation in SH-SY5Y human neuroblastoma cells

Brudvik KW, Paulsen JE, Aandahl EM, Roald B, Taskén K (2011) Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice. Mol Cancer 10:149

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chooi WH, Chew SY (2019) Modulation of cell-cell interactions for neural tissue engineering: potential therapeutic applications of cell adhesion molecules in nerve regeneration. Biomaterials 197:327–344

Article  CAS  PubMed  Google Scholar 

Chou H-Y, Howng S-L, Cheng T-S, Hsiao Y-L, Lieu A-S, Loh J-K, Hwang S-L, Lin C-C, Hsu C-M, Wang C et al (2006) GSKIP Is homologous to the axin GSK3β interaction domain and functions as a negative regulator of GSK3β. Biochemistry 45:11379–11389

Article  CAS  PubMed  Google Scholar 

Chou C-H, Yang M-C, Hsiao B-X, Wang Y-H, Liu H-F, Chiou S-J, Chuang Y-C, Yang C-N, Lieu A-S, Loh J-K et al (2018) The origin of GSKIP a multifaceted regulatory factor in the mammalian Wnt pathway. Biochim Et Biophys Acta (BBA) Mol Cell Res 1865:1046–1059

Article  CAS  Google Scholar 

Cole A, Frame S, Cohen P (2004) Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event. Biochem J 377:249–255

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai FQ, Li CR, Fan XQ, Tan L, Wang RT, Jin H (2019) miR-150-5p inhibits non-small-cell lung cancer metastasis and recurrence by targeting HMGA2 and β-catenin signaling. Mol Ther Nucleic Acids 16:675–685

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deák VA, Skroblin P, Dittmayer C, Knobeloch K-P, Bachmann S, Klussmann E (2016) The A-kinase anchoring protein GSKIP regulates GSK3β activity and controls palatal shelf fusion in mice. J Biol Chem 291:681–690

Article  PubMed  Google Scholar 

Dema A, Schröter MF, Perets E, Skroblin P, Moutty MC, Deàk VA, Birchmeier W, Klussmann E (2016) The A-kinase anchoring protein (AKAP) glycogen synthase kinase 3β interaction protein (GSKIP) regulates β-catenin through its interactions with both protein kinase A (PKA) and GSK3β. J Biol Chem 291:19618–19630

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duployez N, Lejeune S, Renneville A, Preudhomme C (2016) Myelodysplastic syndromes and acute leukemia with genetic predispositions: a new challenge for hematologists. Expert Rev Hematol 9:1189–1202

Article  CAS  PubMed  Google Scholar 

Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, Mills GB, Kobayashi R, Hunter T, Lu Z (2007) Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem 282:11221–11229

Article  CAS  PubMed  Google Scholar 

Haÿ E, Buczkowski T, Marty C, Da Nascimento S, Sonnet P, Marie PJ (2012) Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation. J Bone Miner Res 27:1852–1863

Article  PubMed  Google Scholar 

Hollestelle A, Peeters JK, Smid M, Timmermans M, Verhoog LC, Westenend PJ, Heine AA, Chan A, Sieuwerts AM, Wiemer EA et al (2013) Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer. Breast Cancer Res Treat 138:47–57

Article  CAS  PubMed  Google Scholar 

Howng SL, Hwang CC, Hsu CY, Hsu MY, Teng CY, Chou CH, Lee MF, Wu CH, Chiou SJ, Lieu AS et al (2010) Involvement of the residues of GSKIP, AxinGID, and FRATtide in their binding with GSK3beta to unravel a novel C-terminal scaffold-binding region. Mol Cell Biochem 339:23–33

Article  CAS  PubMed  Google Scholar 

Hundsrucker C, Skroblin P, Christian F, Zenn HM, Popara V, Joshi M, Eichhorst J, Wiesner B, Herberg FW, Reif B et al (2010) Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem 285:5507–5521

Article  CAS  PubMed  Google Scholar 

Kalluri R (2009) EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest 119:1417–1419

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ko H-J, Chiou S-J, Wong Y-H, Wang Y-H, Lai Y, Chou C-H, Wang C, Loh J-K, Lieu A-S, Cheng J-T et al (2019) GSKIP-mediated anchoring increases phosphorylation of tau by PKA but not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis signaling in cerebrospinal fluid and iPS cells in Alzheimer disease. J Clin Med 8:1751

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar R, Bashyam MD (2017) Multiple oncogenic roles of nuclear beta-catenin. J Biosci 42:695–707

Article  CAS  PubMed  Google Scholar 

Lai X, Li Q, Wu F, Lin J, Chen J, Zheng H, Guo L (2020) Epithelial-mesenchymal transition and metabolic switching in cancer: lessons from somatic cell reprogramming. Front Cell Dev Biol 8:760

Article  PubMed  PubMed Central  Google Scholar 

Li Q, Mattingly RR (2008) Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast epithelial cells. Neoplasia 10:1444–1458

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li N, Cheng C, Wang T (2020) MiR-181c-5p mitigates tumorigenesis in cervical squamous cell carcinoma via targeting glycogen synthase kinase 3β interaction protein (GSKIP). Onco Targets Ther 13:4495–4505

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin CC, Chou CH, Howng SL, Hsu CY, Hwang CC, Wang C, Hsu CM, Hong YR (2009) GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells. J Cell Biochem 108:1325–1336

Article  CAS  PubMed  Google Scholar 

Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108:837–847

Article  CAS  PubMed  Google Scholar 

Loh JK, Lin CC, Yang MC, Chou CH, Chen WS, Hong MC, Cho CL, Hsu CM, Cheng JT, Chou AK et al (2015) GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation. Biochim Biophys Acta 1853:1796–1807

Article  CAS  PubMed  Google Scholar 

Loh C-Y, Chai JY, Tang TF, Wong WF, Sethi G, Shanmugam MK, Chong PP, Looi CY (2019) The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges. Cells 8:1118

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miyamoto Y, Sakane F, Hashimoto K (2015) N-cadherin-based adherens junction regulates the maintenance, proliferation, and differentiation of neural progenitor cells during development. Cell Adh Migr 9:183–192

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mrozik KM, Blaschuk OW, Cheong CM, Zannettino ACW, Vandyke K (2018) N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer. BMC Cancer 18:939

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nishimura T, Nakamura H, Yachie A, Hase T, Fujii K, Koizumi H, Naruki S, Takagi M, Matsuoka Y, Furuya N et al (2020) Disease-related cellular protein networks differentially affected under different EGFR mutations in lung adenocarcinoma. Sci Rep 10:10881

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pastushenko I, Brisebarre A, Sifrim A, Fioramonti M, Revenco T, Boumahdi S, Van Keymeulen A, Brown D, Moers V, Lemaire S et al (2018) Identification of the tumour transition states occurring during EMT. Nature 556:463–468

Article  CAS  PubMed  Google Scholar 

Pilot-Storck F, Chopin E, Rual JF, Baudot A, Dobrokhotov P, Robinson-Rechavi M, Brun C, Cusick ME, Hill DE, Schaeffer L et al (2010) Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Mol Cell Proteom 9:1578–1593

Article  CAS  Google Scholar 

Plo I, Bellanné-Chantelot C, Vainchenker W (2015) ATG2B and GSKIP: 2 new genes predisposing to myeloid malignancies. Mol Cell Oncol 3:e1094564–e1094564

Article  PubMed  PubMed Central  Google Scholar 

Saliba J, Saint-Martin C, Di Stefano A, Lenglet G, Marty C, Keren B, Pasquier F, Valle VD, Secardin L, Leroy G et al (2015) Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies. Nat Genet 47:1131–1140

Article  CAS  PubMed  Google Scholar 

Skroblin P, Grossmann S, Schäfer G, Rosenthal W, Klussmann E (2010) Chapter five - mechanisms of protein kinase A anchoring. In: Jeon K (ed) International review of cell and molecular biology. Academic Press, Cambridge, pp 235–330

Google Scholar 

Sorrenson B, Dissanayake WC, Hu F, Lee KL, Shepherd PR (2021) A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion. Biochem J 478:1605–1615

Article  CAS  PubMed  Google Scholar 

Sulaiman A, Yao ZM, Wang LS (2018) Re-evaluating the role of epithelial-mesenchymal-transition in cancer progression. J Biomed Res 32:81–90

Article  PubMed  Google Scholar 

留言 (0)

沒有登入
gif