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metadata.dc.identifier.doi: https://doi.org/10.56042/ijeb.v61i05.856Title: Protective effects of safranal against subchronic thinner inhalation induced oxidative stress in ratsAuthors: Sevimli, S
Karafakıoğlu, Y
Hazman, Ö
Düz, M
Kan, FKeywords: Brain;Crocus sativus;Lungs;Saffron;Volatile organic solventsIssue Date: May-2023Publisher: NIScPR-CSIR, IndiaAbstract: In phytotherapy, research on the effects of components in plant extracts on various diseases gets increasing attention. . Saffron is an herb with antioxidant effects, known to have an increasing significance due to its therapeutic effects. Safranal is one of the components of saffron extract. Here, we explored the effects of subchronic thinner inhalation on the oxidant-antioxidant balance, the relation between toxicity and oxidative stress, and a possible protective effect of safranal against thinner toxication in rats. Sprague−Dawley rats were divided into four groups as follows: control (Gr. I), safranal (Gr. II), thinner (Gr. III) and thinner+safranal Gr. IV). Each group consisted of 10 rats, and the study lasted for 8 weeks. After completing the animal studies malondialdehyde (MDA), reduced glutathione (GSH), toluol, 8OHdG (8-hydroxy-2-deoxyguanosine), protein oxidation, nitric oxide metabolites (NOx), total antioxidant capacity (TAC), total oxidant capacity (TOC), glucose, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, WBC, VLDL, RBC, HCT, Hb, aspartate amino transferase (AST), and alanine amino transferase (ALT) levels were determined from blood specimens of the rats. Brain and lung tissues were also examined histopathologically. The data obtained from the study were statistically analyzed using SPSS, and both ANCOVA and Bonferroni tests were performed. P Page(s): 339-348ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:IJEB Vol.61(05) [May 2023]

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