CD40 induces selective routing of Ras isoforms to subcellular compartments

Augsten M, Pusch R, Biskup C, Rennert K, Wittig U, Beyer K, Blume A, Wetzker R, Friedrich K, Rubio I (2006) Live‐cell imaging of endogenous Ras‐GTP illustrates predominant Ras activation at the plasma membrane. EMBO Rep 7(1):46–51

Article  CAS  PubMed  Google Scholar 

Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, Mor A, Minura J, Wiener HH, Wright L, Saba SG, Yim D, Fein A, de Castro IP, Li C, Thompson CB, Cox AD, Philips MR (2006) PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell 21(4):481–493

Article  CAS  PubMed  Google Scholar 

Casar B, Badrock AP, Jiménez I, Arozarena I, Colón-Bolea P, Lorenzo-Martín L, Barinaga-Rementería I, Barriuso J, Cappitelli V, Donoghue DJ, Bustelo XR, Hurlstone A, Crespo P (2018) RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation. Nat Commun 9(1):1–17

Article  CAS  Google Scholar 

Chakraborty S, Srivastava A, Jha MK, Nair A, Pandey SP, Srivastava N, Kumari S, Singh S, Krishnasastry MV, Saha B (2015) Inhibition of CD40-induced N-Ras activation reduces leishmania major infection. J Immunol 194:3852–3860

Article  CAS  PubMed  Google Scholar 

Chiu VK, Bivona T, Hach A, Sajous JB, Silletti J, Wiener H, Johnson RL, Cox AD, Philips MR (2002) Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol 4:343–350

Article  CAS  PubMed  Google Scholar 

Cox AD, Der CJ (2003) The dark side of Ras: regulation of apoptosis. Oncogene 22:8999–9006

Article  CAS  PubMed  Google Scholar 

Crespo P, Leon J (2000) Ras proteins in the control of the cell cycle and cell differentiation. Cell Mol Life Sci CMLS 57:1613–1636

Article  CAS  PubMed  Google Scholar 

Dunn KW, Kamocka MM, McDonald JH (2011) A practical guide to evaluating colocalization in biological microscopy. Am J Physiol Cell Physiol 300:C723–C742

Article  CAS  PubMed  PubMed Central  Google Scholar 

Filippakis H, Spandidos DA, Sourvinos G (2010) Herpesviruses: hijacking the Ras signaling pathway. Biochim Biophys Acta (BBA) Mol Cell Res 1803:777–785

Hobbs GA, Der CJ, Rossman KL (2016) RAS isoforms and mutations in cancer at a glance. J Cell Sci 129:1287–1292

CAS  PubMed  PubMed Central  Google Scholar 

Le Floc’h A, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonnet G, Fukui Y, Huse M (2013) Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse. J Exp Med 210:2721–2737

Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS (2001) Evaluation of farnesyl: protein transferase and geranylgeranyl: protein transferase inhibitor combinations in preclinical models. Can Res 61:8758–8768

CAS  Google Scholar 

Lynch SJ, Snitkin H, Gumper I, Philips MR, Sabatini D, Pellicer A (2015) The differential palmitoylation states of N-Ras and H-Ras determine their distinct Golgi subcompartment localizations. J Cell Physiol 230:610–619

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manns M, Leske O, Gottfried S, Bichler Z, Lafenêtre P, Wahle P, Heumann R (2011) Role of neuronal ras activity in adult hippocampal neurogenesis and cognition. Front Neurosci 5:18

Article  PubMed  PubMed Central  Google Scholar 

Messina S (2020) Small GTPase RAS in multiple sclerosis-exploring the role of RAS GTPase in the etiology of multiple sclerosis. Small GTPases 11:312–319

Article  PubMed  Google Scholar 

Michaelson D, Silletti J, Murphy G, D’Eustachio P, Rush M, Philips MR (2001) Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. J Cell Biol 152:111–126

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mor A, Philips MR (2006) Compartmentalized ras/mapk signaling. Annu Rev Immunol 24:771–800

Article  CAS  PubMed  Google Scholar 

Muñoz-Maldonado C, Zimmer Y, Medová M (2019) A comparative analysis of individual RAS mutations in cancer biology. Front Oncol 9:1088

Article  PubMed  PubMed Central  Google Scholar 

Murholm M, Dixen K, Hansen JB (2010) Ras signalling regulates differentiation and UCP1 expression in models of brown adipogenesis. Biochim Biophys Acta (BBA) General Subj 1800:619–627

Nair A, Chakraborty S, Banerji LA, Srivastava A, Navare C, Saha B (2020) Ras isoforms: signaling specificities in CD40 pathway. Cell Commun Signal 18:1–12

Article  Google Scholar 

Nair A, Kubatzky KF, Saha B (2021) Ras isoforms from lab benches to lives—What are we missing and how far are we? Int J Mol Sci 22:6508

Article  CAS  PubMed  PubMed Central  Google Scholar 

Neven Q, Boulanger C, Bruwier A, de Ville de Goyet M, Meyts I, Moens L, Van Damme A, Brichard B (2021) Clinical spectrum of ras-associated autoimmune leukoproliferative disorder (RALD). J Clin Immunol 41:51–58

Potenza N, Vecchione C, Notte A, De Rienzo A, Rosica A, Bauer L, Affuso A, De Felice M, Russo T, Poulet R (2005) Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice EMBO Rep 6:432–437

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prakash P, Sayyed-Ahmad A, Cho K-J, Dolino DM, Chen W, Li H, Grant BJ, Hancock JF, Gorfe AA (2017) Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers. Sci Rep 7:40109

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prior IA, Hancock JF (2012) Ras trafficking, localization and compartmentalized signaling. In: Seminars in cell and developmental biology. Elsevier, New York, pp 145–153

Prior IA, Lewis PD, Mattos C (2012) A comprehensive survey of Ras mutations in cancer. Cancer Res 72(10):2457–2467

Rauen KA (2013) The rasopathies. Annu Rev Genomics Hum Genet 14:355–369

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rub, A, Dey R, Jadhav M, Kamat R, Chakkaramakkil S, Majumdar S, Mukhopadhyaya R, Saha B (2009) Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function. Nature Immunol 10(3):273–280

Santra T, Herrero A, Rodriguez J, von Kriegsheim A, Iglesias-Martinez LF, Schwarzl T, Higgins D, Aye T-T, Heck AJ, Calvo F (2019) An integrated global analysis of compartmentalized HRAS signaling. Cell Rep 26:3100-3115.e7

Article  CAS  PubMed  Google Scholar 

Sarkar-Banerjee S, Sayyed-Ahmad A, Prakash P, Cho K-J, Waxham MN, Hancock JF, Gorfe AA (2017) Spatiotemporal analysis of K-Ras plasma membrane interactions reveals multiple high order homo-oligomeric complexes. J Am Chem Soc 139:13466–13475

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sciacchitano S, Sacconi A, De Vitis C, Blandino G, Piaggio G, Salvati V, Napoli C, Marchetti P, Taurelli BS, Coluzzi F (2021) H-Ras gene takes part to the host immune response to COVID-19. Cell Death Discov 7:158

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wolfman JC, Planchon SM, Liao J, Wolfman A (2006) Structural and functional consequences of cN-Ras constitutively associated with intact mitochondria. Biochim Biophys Acta (BBA)-Mol Cell Res 1763(10):1108–1124

Zayoud M, Marcu-Malina V, Vax E, Jacob-Hirsch J, Elad-Sfadia G, Barshack I, Kloog Y, Goldstein I (2017) Ras signaling inhibitors attenuate disease in adjuvant-induced arthritis via targeting pathogenic antigen-specific Th17-type cells. Front Immunol 8:799

Article  PubMed  PubMed Central  Google Scholar 

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