Which Second-Line Tyrosine Kinase Inhibitor(s) for Chronic Myeloid Leukemia?

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Hochhaus A, et al. European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia. Leukemia. 2020. https://doi.org/10.1038/s41375-020-0776-2. This paper is of importance as it serves as the official guidelines and recommendations by the European LeukemiaNet panel for the monitoring and reatment of CML in the first line and second line, along with side effects that must be considered with each TKI.

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Soverini S, et al. BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood. 2011. https://doi.org/10.1182/blood-2010-12-326405.

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Castagnetti F, et al. Dose optimization in elderly CML patients treated with bosutinib after intolerance or failure of first-line tyrosine kinase inhibitors. Blood. 2019. https://doi.org/10.1182/blood-2019-127514. This abstract was of particular importance as it was phase 2 single arm study showing the tolerability of bosutinib in elderly patients who have previously failed first line TKIs.

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Braun TP, Eide CA, Druker BJ. Response and resistance to BCR-ABL1-targeted therapies. Cancer Cell. 2020. https://doi.org/10.1016/j.ccell.2020.03.006. This paper is of importance as it is an in-depth review of mechanism that leads to TKI resistance and strategies to overcome resistance.

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