Visceral mesenchymal stem cells from type 2 diabetes donors activate triglycerides synthesis in healthy adipocytes via metabolites exchange and cytokines secretion

Ladabaum U, Mannalithara A, Myer PA, Singh G. Obesity, abdominal obesity, physical activity, and caloric intake in U.S. adults: 1988–2010. Am J Med. 2014;127:717–27.e12.

Article  PubMed  PubMed Central  Google Scholar 

Hall KD, Ayuketah A, Brychta R, Cai H, Cassimatis T, Chen KY, et al. Ultra-processed diets cause excess calorie intake and weight gain: An inpatient randomized controlled trial of ad libitum food intake. Cell Metab. 2019;30:67–77.e3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Wang X, Zhang Q, Meng G, Liu L, Wu H, et al. Relationship between dietary patterns and carotid atherosclerosis among people aged 50 years or older: A population-based study in China. Front Nutr. 2021;8,723726.

Yang T, Zhao B, Pei D. Evaluation of the association between obesity markers and type 2 diabetes: a cohort study based on a physical examination population, J.Diabetes.Res. 2021;6503339.

American Diabetes Association Professional Practice Committee, Draznin B, Aroda VR, Bakris G, Benson G, Brown FM, et al. Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of medical care in diabetes-2022. Diabetes Care. 2022;45:S113–S124.

Article  Google Scholar 

Blüher M. Metabolically healthy obesity. Endocr Rev. 2020;41:bnaa004.

Shestakova EA, Yashkov YI, Rebrova OY, Kats MV, Samsonova MD, Dedov II. Obesity with and without type 2 diabetes: Are there differences in obesity history, lifestyle factors or concomitant pathology? Obes Metab. 2020;17:332–9.

Article  Google Scholar 

Cleal L, Aldea T, Chau YY. Fifty shades of white: Understanding heterogeneity in white adipose stem cells. Adipocyte. 2017;6:205–16.

Article  PubMed  PubMed Central  Google Scholar 

Guo DH, Yamamoto M, Hernandez CM, Khodadadi H, Baban B, Stranahan AM. Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice, Nat Commun. 2021;12:4623.

Wildman RP, Janssen I, Khan UI, Thurston R, Barinas-Mitchell E, El Khoudary SR, et al. Subcutaneous adipose tissue in relation to subclinical atherosclerosis and cardiometabolic risk factors in midlife women. Am J Clin Nutr. 2011;93:719–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gastaldelli A, Miyazaki Y, Pettiti M, Matsuda M, Mahankali S, Santini E, et al. Metabolic effects of visceral fat accumulation in type 2 diabetes. J Clin Endocrinol Metab. 2002;87:5098–103.

Article  CAS  PubMed  Google Scholar 

Ko YH, Wong TC, Hsu YY, Kuo KL, Yang SH. The correlation between body fat, visceral fat, and nonalcoholic fatty liver disease. Metab Syndr Relat Disord. 2017;15:304–11.

Article  CAS  PubMed  Google Scholar 

Sorimachi H, Obokata M, Takahashi N, Reddy YNV, Jain CC, Verbrugge FH, et al. Pathophysiologic importance of visceral adipose tissue in women with heart failure and preserved ejection fraction. Eur Heart J. 2021;42:1595–605.

Article  PubMed  Google Scholar 

Chait A, den Hartigh LJ. Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Front Cardiovasc Med. 2020;7:22.

Sebag SC, Zhang Z, Qian Q, Li M, Zhu Z, Harata M, et al. ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue. Cell Rep. 2021;37:1100003.

Wang CH, Lundh M, Fu A, Kriszt R, Huang TL, Lynes MD, et al. CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Sci Transl Med. 2020;12:eaaz8664.

Spalding KL, Bernard S, Näslund E, Salehpour M, Possnert G, Appelsved L, et al. Impact of fat mass and distribution on lipid turnover in human adipose tissue. Nat Commun. 2017;8:15253.

Petersen MC, Shulman GI. Mechanisms of insulin action and insulin resistance. Physiol Rev. 2018;98:2133–233.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vorotnikov AV, Stafeev IS, Menshikov MY, Shestakova MV, Parfyonova YeV. Latent inflammation and defect in adipocyte renewal as a mechanism of obesity-associated insulin resistance. Biochemistry (Moscow). 2019;84:1329–45.

Article  CAS  PubMed  Google Scholar 

Cawthorn WP, Scheller EL, MacDougald OA. Adipose tissue stem cells meet preadipocyte commitment: going back to the future. J Lipid Res. 2012;53:227–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Melief SM, Zwaginga JJ, Fibbe WE, Roelofs H. Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrow-derived counterparts. Stem Cells Transl Med. 2013;2:455–63.

Article  PubMed  PubMed Central  Google Scholar 

Hammarstedt A, Gogg S, Hedjazifar S, Nerstedt A, Smith U. Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity. Physiol Rev. 2018;98:1911–41.

Article  CAS  PubMed  Google Scholar 

Stafeev I, Podkuychenko N, Michurina S, Sklyanik I, Panevina A, Shestakova E, et al. Low proliferative potential of adipose-derived stromal cells associates with hypertrophy and inflammation in subcutaneous and omental adipose tissue of patients with type 2 diabetes mellitus. J Diabetes Complications. 2019;33:148–59.

Article  CAS  PubMed  Google Scholar 

Michurina S, Stafeev I, Podkuychenko N, Sklyanik I, Shestakova E, Yah’yaev K, et al. Decreased UCP-1 expression in beige adipocytes from adipose-derived stem cells of type 2 diabetes patients associates with mitochondrial ROS accumulation during obesity. Diab Res Clin Pract. 2020;169:108410.

Article  CAS  Google Scholar 

Skubis-Sikora A, Sikora B, Witkowska A, Mazurek U, Gola J. Osteogenesis of adipose-derived stem cells from patients with glucose metabolism disorders. Mol Med. 2020;26:67.

Article  PubMed  PubMed Central  Google Scholar 

Agareva M, Stafeev I, Michurina S, Sklyanik I, Shestakova E, Ratner E, et al. Type 2 diabetes mellitus facilitates shift of adipose-derived stem cells ex vivo differentiation toward osteogenesis among patients with obesity. Life (Basel). 2022;12:688.

CAS  PubMed  PubMed Central  Google Scholar 

Liao N, Zheng Y, Xie H, Zhao B, Zeng Y, Liu X, et al. Adipose tissue-derived stem cells ameliorate hyperglycemia, insulin resistance and liver fibrosis in the type 2 diabetic rats. Stem Cell Res Ther. 2017;8:286.

Article  PubMed  PubMed Central  Google Scholar 

Zhao H, Shang Q, Pan Z, Bai Y, Li Z, Zhang H, et al. Exosomes from adipose-derived stem cells attenuate adipose inflammation and obesity through polarizing M2 macrophages and beiging in white adipose tissue. Diabetes. 2018;67:235–47.

Article  CAS  PubMed  Google Scholar 

Zhang X, Jiang Y, Huang Q, Wu Z, Pu H, Xu Z, et al. Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb ischemia. Stem Cell Res Ther. 2021;12:403.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jung S, Kleineidam B, Kleinheinz J. Regenerative potential of human adipose-derived stromal cells of various origins. J Cran Surg. 2015;43:2144–51.

Google Scholar 

Silva KR, Baptista LS. Adipose-derived stromal/stem cells from different adipose depots in obesity development. World J Stem Cells. 2019;11:147–66.

Article  PubMed  PubMed Central  Google Scholar 

Ritter A, Friemel A, Roth S, Kreis NN, Hoock SC, Safdar BK, et al. Subcutaneous and visceral adipose-derived mesenchymal stem cells: commonality and diversity. Cells. 2019;8:E1288.

Article  Google Scholar 

Nagasaki H, Shang Q, Suzuki T, Hashimoto H, Yoshimura T, Kondo TA, et al. Low-serum culture system improves the adipogenic ability of visceral adipose tissue-derived stromal cells. Cell Biol Int. 2011;35:559–68.

Article  PubMed  Google Scholar 

Michaud A, Lacroix-Pepin N, Pelletier M, Daris M, Biertho L, Fortier MA, et al. Expression of genes related to prostaglandin synthesis or signaling in human subcutaneous and omental adipose tissue: depot differences and modulation by adipogenesis. Mediators Inflamm. 2014;2014:451620.

Article  PubMed  PubMed Central  Google Scholar 

Koppe MJ, Nagtegaal ID, de Wilt JH, Ceelen WP. Recent insights into the pathophysiology of omental metastases. J Surg Oncol. 2014;110:670–5.

Article  PubMed  Google Scholar 

Bunnell BA, Flaat M, Gagliardi C, Patel B, Ripoll C. Adipose-derived stem cells: Isolation, expansion and differentiation. Methods. 2008;45:115–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Griffin M, Ryan CM, Pathan O, Abraham D, Denton CP, Butler PEM. Characteristics of human adipose derived stem cells in scleroderma in comparison to sex and age matched normal controls: implications for regenerative medicine. Stem Cell Res Ther. 2017;8:23.

Article  PubMed  PubMed Central  Google Scholar 

Exner T, Beretta CA, Gao Q, Afting C, Romero-Brey I, Bartenschlager R, et al. Lipid droplet quantification based on iterative image processing. J Lipid Res. 2019;60:1333–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huynh FK, Green MF, Koves TR, Hirschey MD. Measurement of fatty acid oxidation rates in animal tissues and cell lines. Methods Enzymol. 2014;542:391–405.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reis A, Rudnitskaya A, Blackburn GJ, Fauzi NM, Pitt AR, Spickett CM. A comparison of five lipid extraction solvent systems for lipidomic studies of human LDL. J Lipid Res. 2013;54:1812–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lund J, Aas V, Tingstad RH, Van Hees A, Nikolić N. Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism. Sci Rep. 2018;8:9814.

Article  PubMed  PubMed Central  Google Scholar 

de Assis-Ferreira A, Saldanha-Gama R, Mesquita de Brito N, Renovato-Martins M, Loureiro Simões R, Barja-Fidalgo C, et al. Obesity enhances the recruitment of mesenchymal stem cells to visceral adipose tissue. J Mol Endocrinol. 2021;67:15–26.

Article  PubMed  Google Scholar 

Zuo Y, Xiao T, Qiu X, Liu Z, Zhang S, Zhou N. Adiponectin reduces apoptosis of diabetic cardiomyocytes by regulating miR-711/TLR4 axis. Diabetol Metab Syndr. 2022;14:131.

留言 (0)

沒有登入
gif