Ladabaum U, Mannalithara A, Myer PA, Singh G. Obesity, abdominal obesity, physical activity, and caloric intake in U.S. adults: 1988–2010. Am J Med. 2014;127:717–27.e12.
Article PubMed PubMed Central Google Scholar
Hall KD, Ayuketah A, Brychta R, Cai H, Cassimatis T, Chen KY, et al. Ultra-processed diets cause excess calorie intake and weight gain: An inpatient randomized controlled trial of ad libitum food intake. Cell Metab. 2019;30:67–77.e3.
Article CAS PubMed PubMed Central Google Scholar
Liu Y, Wang X, Zhang Q, Meng G, Liu L, Wu H, et al. Relationship between dietary patterns and carotid atherosclerosis among people aged 50 years or older: A population-based study in China. Front Nutr. 2021;8,723726.
Yang T, Zhao B, Pei D. Evaluation of the association between obesity markers and type 2 diabetes: a cohort study based on a physical examination population, J.Diabetes.Res. 2021;6503339.
American Diabetes Association Professional Practice Committee, Draznin B, Aroda VR, Bakris G, Benson G, Brown FM, et al. Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of medical care in diabetes-2022. Diabetes Care. 2022;45:S113–S124.
Blüher M. Metabolically healthy obesity. Endocr Rev. 2020;41:bnaa004.
Shestakova EA, Yashkov YI, Rebrova OY, Kats MV, Samsonova MD, Dedov II. Obesity with and without type 2 diabetes: Are there differences in obesity history, lifestyle factors or concomitant pathology? Obes Metab. 2020;17:332–9.
Cleal L, Aldea T, Chau YY. Fifty shades of white: Understanding heterogeneity in white adipose stem cells. Adipocyte. 2017;6:205–16.
Article PubMed PubMed Central Google Scholar
Guo DH, Yamamoto M, Hernandez CM, Khodadadi H, Baban B, Stranahan AM. Beige adipocytes mediate the neuroprotective and anti-inflammatory effects of subcutaneous fat in obese mice, Nat Commun. 2021;12:4623.
Wildman RP, Janssen I, Khan UI, Thurston R, Barinas-Mitchell E, El Khoudary SR, et al. Subcutaneous adipose tissue in relation to subclinical atherosclerosis and cardiometabolic risk factors in midlife women. Am J Clin Nutr. 2011;93:719–26.
Article CAS PubMed PubMed Central Google Scholar
Gastaldelli A, Miyazaki Y, Pettiti M, Matsuda M, Mahankali S, Santini E, et al. Metabolic effects of visceral fat accumulation in type 2 diabetes. J Clin Endocrinol Metab. 2002;87:5098–103.
Article CAS PubMed Google Scholar
Ko YH, Wong TC, Hsu YY, Kuo KL, Yang SH. The correlation between body fat, visceral fat, and nonalcoholic fatty liver disease. Metab Syndr Relat Disord. 2017;15:304–11.
Article CAS PubMed Google Scholar
Sorimachi H, Obokata M, Takahashi N, Reddy YNV, Jain CC, Verbrugge FH, et al. Pathophysiologic importance of visceral adipose tissue in women with heart failure and preserved ejection fraction. Eur Heart J. 2021;42:1595–605.
Chait A, den Hartigh LJ. Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Front Cardiovasc Med. 2020;7:22.
Sebag SC, Zhang Z, Qian Q, Li M, Zhu Z, Harata M, et al. ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue. Cell Rep. 2021;37:1100003.
Wang CH, Lundh M, Fu A, Kriszt R, Huang TL, Lynes MD, et al. CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Sci Transl Med. 2020;12:eaaz8664.
Spalding KL, Bernard S, Näslund E, Salehpour M, Possnert G, Appelsved L, et al. Impact of fat mass and distribution on lipid turnover in human adipose tissue. Nat Commun. 2017;8:15253.
Petersen MC, Shulman GI. Mechanisms of insulin action and insulin resistance. Physiol Rev. 2018;98:2133–233.
Article CAS PubMed PubMed Central Google Scholar
Vorotnikov AV, Stafeev IS, Menshikov MY, Shestakova MV, Parfyonova YeV. Latent inflammation and defect in adipocyte renewal as a mechanism of obesity-associated insulin resistance. Biochemistry (Moscow). 2019;84:1329–45.
Article CAS PubMed Google Scholar
Cawthorn WP, Scheller EL, MacDougald OA. Adipose tissue stem cells meet preadipocyte commitment: going back to the future. J Lipid Res. 2012;53:227–46.
Article CAS PubMed PubMed Central Google Scholar
Melief SM, Zwaginga JJ, Fibbe WE, Roelofs H. Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrow-derived counterparts. Stem Cells Transl Med. 2013;2:455–63.
Article PubMed PubMed Central Google Scholar
Hammarstedt A, Gogg S, Hedjazifar S, Nerstedt A, Smith U. Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity. Physiol Rev. 2018;98:1911–41.
Article CAS PubMed Google Scholar
Stafeev I, Podkuychenko N, Michurina S, Sklyanik I, Panevina A, Shestakova E, et al. Low proliferative potential of adipose-derived stromal cells associates with hypertrophy and inflammation in subcutaneous and omental adipose tissue of patients with type 2 diabetes mellitus. J Diabetes Complications. 2019;33:148–59.
Article CAS PubMed Google Scholar
Michurina S, Stafeev I, Podkuychenko N, Sklyanik I, Shestakova E, Yah’yaev K, et al. Decreased UCP-1 expression in beige adipocytes from adipose-derived stem cells of type 2 diabetes patients associates with mitochondrial ROS accumulation during obesity. Diab Res Clin Pract. 2020;169:108410.
Skubis-Sikora A, Sikora B, Witkowska A, Mazurek U, Gola J. Osteogenesis of adipose-derived stem cells from patients with glucose metabolism disorders. Mol Med. 2020;26:67.
Article PubMed PubMed Central Google Scholar
Agareva M, Stafeev I, Michurina S, Sklyanik I, Shestakova E, Ratner E, et al. Type 2 diabetes mellitus facilitates shift of adipose-derived stem cells ex vivo differentiation toward osteogenesis among patients with obesity. Life (Basel). 2022;12:688.
CAS PubMed PubMed Central Google Scholar
Liao N, Zheng Y, Xie H, Zhao B, Zeng Y, Liu X, et al. Adipose tissue-derived stem cells ameliorate hyperglycemia, insulin resistance and liver fibrosis in the type 2 diabetic rats. Stem Cell Res Ther. 2017;8:286.
Article PubMed PubMed Central Google Scholar
Zhao H, Shang Q, Pan Z, Bai Y, Li Z, Zhang H, et al. Exosomes from adipose-derived stem cells attenuate adipose inflammation and obesity through polarizing M2 macrophages and beiging in white adipose tissue. Diabetes. 2018;67:235–47.
Article CAS PubMed Google Scholar
Zhang X, Jiang Y, Huang Q, Wu Z, Pu H, Xu Z, et al. Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb ischemia. Stem Cell Res Ther. 2021;12:403.
Article CAS PubMed PubMed Central Google Scholar
Jung S, Kleineidam B, Kleinheinz J. Regenerative potential of human adipose-derived stromal cells of various origins. J Cran Surg. 2015;43:2144–51.
Silva KR, Baptista LS. Adipose-derived stromal/stem cells from different adipose depots in obesity development. World J Stem Cells. 2019;11:147–66.
Article PubMed PubMed Central Google Scholar
Ritter A, Friemel A, Roth S, Kreis NN, Hoock SC, Safdar BK, et al. Subcutaneous and visceral adipose-derived mesenchymal stem cells: commonality and diversity. Cells. 2019;8:E1288.
Nagasaki H, Shang Q, Suzuki T, Hashimoto H, Yoshimura T, Kondo TA, et al. Low-serum culture system improves the adipogenic ability of visceral adipose tissue-derived stromal cells. Cell Biol Int. 2011;35:559–68.
Michaud A, Lacroix-Pepin N, Pelletier M, Daris M, Biertho L, Fortier MA, et al. Expression of genes related to prostaglandin synthesis or signaling in human subcutaneous and omental adipose tissue: depot differences and modulation by adipogenesis. Mediators Inflamm. 2014;2014:451620.
Article PubMed PubMed Central Google Scholar
Koppe MJ, Nagtegaal ID, de Wilt JH, Ceelen WP. Recent insights into the pathophysiology of omental metastases. J Surg Oncol. 2014;110:670–5.
Bunnell BA, Flaat M, Gagliardi C, Patel B, Ripoll C. Adipose-derived stem cells: Isolation, expansion and differentiation. Methods. 2008;45:115–20.
Article CAS PubMed PubMed Central Google Scholar
Griffin M, Ryan CM, Pathan O, Abraham D, Denton CP, Butler PEM. Characteristics of human adipose derived stem cells in scleroderma in comparison to sex and age matched normal controls: implications for regenerative medicine. Stem Cell Res Ther. 2017;8:23.
Article PubMed PubMed Central Google Scholar
Exner T, Beretta CA, Gao Q, Afting C, Romero-Brey I, Bartenschlager R, et al. Lipid droplet quantification based on iterative image processing. J Lipid Res. 2019;60:1333–44.
Article CAS PubMed PubMed Central Google Scholar
Huynh FK, Green MF, Koves TR, Hirschey MD. Measurement of fatty acid oxidation rates in animal tissues and cell lines. Methods Enzymol. 2014;542:391–405.
Article CAS PubMed PubMed Central Google Scholar
Reis A, Rudnitskaya A, Blackburn GJ, Fauzi NM, Pitt AR, Spickett CM. A comparison of five lipid extraction solvent systems for lipidomic studies of human LDL. J Lipid Res. 2013;54:1812–24.
Article CAS PubMed PubMed Central Google Scholar
Lund J, Aas V, Tingstad RH, Van Hees A, Nikolić N. Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism. Sci Rep. 2018;8:9814.
Article PubMed PubMed Central Google Scholar
de Assis-Ferreira A, Saldanha-Gama R, Mesquita de Brito N, Renovato-Martins M, Loureiro Simões R, Barja-Fidalgo C, et al. Obesity enhances the recruitment of mesenchymal stem cells to visceral adipose tissue. J Mol Endocrinol. 2021;67:15–26.
Zuo Y, Xiao T, Qiu X, Liu Z, Zhang S, Zhou N. Adiponectin reduces apoptosis of diabetic cardiomyocytes by regulating miR-711/TLR4 axis. Diabetol Metab Syndr. 2022;14:131.
留言 (0)