de Benoist B, McLean E, Andersson M, Rogers L (2008) Iodine deficiency in 2007: global progress since 2003. Food Nutr Bull 29(3):195–202. https://doi.org/10.1177/156482650802900305

Article  PubMed  Google Scholar 

Zimmermann MB (2009) Iodine deficiency. Endocr Rev 30(4):376–408. https://doi.org/10.1210/er.2009-0011

Article  CAS  PubMed  Google Scholar 

Trampush JW, Yang ML, Yu J, Knowles E, Davies G, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, DeRosse P, Lundervold AJ, Steen VM, Espeseth T, Raikkonen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Chiba-Falek O, Attix DK, Need AC, Cirulli ET, Voineskos AN, Stefanis NC, Avramopoulos D, Hatzimanolis A, Arking DE, Smyrnis N, Bilder RM, Freimer NA, Cannon TD, London E, Poldrack RA, Sabb FW, Congdon E, Conley ED, Scult MA, Dickinson D, Straub RE, Donohoe G, Morris D, Corvin A, Gill M, Hariri AR, Weinberger DR, Pendleton N, Bitsios P, Rujescu D, Lahti J, Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK, Lencz T (2017) GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. Mol Psychiatry 22(3):336–345. https://doi.org/10.1038/mp.2016.244

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, Bis JC, Burdick KE, Christoforou A, DeRosse P, Djurovic S, Espeseth T, Giakoumaki S, Giddaluru S, Gustavson DE, Hayward C, Hofer E, Ikram MA, Karlsson R, Knowles E, Lahti J, Leber M, Li S, Mather KA, Melle I, Morris D, Oldmeadow C, Palviainen T, Payton A, Pazoki R, Petrovic K, Reynolds CA, Sargurupremraj M, Scholz M, Smith JA, Smith AV, Terzikhan N, Thalamuthu A, Trompet S, van der Lee SJ, Ware EB, Windham BG, Wright MJ, Yang J, Yu J, Ames D, Amin N, Amouyel P, Andreassen OA, Armstrong NJ, Assareh AA, Attia JR, Attix D, Avramopoulos D, Bennett DA, Bohmer AC, Boyle PA, Brodaty H, Campbell H, Cannon TD, Cirulli ET, Congdon E, Conley ED, Corley J, Cox SR, Dale AM, Dehghan A, Dick D, Dickinson D, Eriksson JG, Evangelou E, Faul JD, Ford I, Freimer NA, Gao H, Giegling I, Gillespie NA, Gordon SD, Gottesman RF, Griswold ME, Gudnason V, Harris TB, Hartmann AM, Hatzimanolis A, Heiss G, Holliday EG, Joshi PK, Kahonen M, Kardia SLR, Karlsson I, Kleineidam L, Knopman DS, Kochan NA, Konte B, Kwok JB, Le Hellard S, Lee T, Lehtimaki T, Li SC, Lill CM, Liu T, Koini M, London E, Longstreth WT Jr, Lopez OL, Loukola A, Luck T, Lundervold AJ, Lundquist A, Lyytikainen LP, Martin NG, Montgomery GW, Murray AD, Need AC, Noordam R, Nyberg L, Ollier W, Papenberg G, Pattie A, Polasek O, Poldrack RA, Psaty BM, Reppermund S, Riedel-Heller SG, Rose RJ, Rotter JI, Roussos P, Rovio SP, Saba Y, Sabb FW, Sachdev PS, Satizabal CL, Schmid M, Scott RJ, Scult MA, Simino J, Slagboom PE, Smyrnis N, Soumare A, Stefanis NC, Stott DJ, Straub RE, Sundet K, Taylor AM, Taylor KD, Tzoulaki I, Tzourio C, Uitterlinden A, Vitart V, Voineskos AN, Kaprio J, Wagner M, Wagner H, Weinhold L, Wen KH, Widen E, Yang Q, Zhao W, Adams HHH, Arking DE, Bilder RM, Bitsios P, Boerwinkle E, Chiba-Falek O, Corvin A, De Jager PL, Debette S, Donohoe G, Elliott P, Fitzpatrick AL, Gill M, Glahn DC, Hagg S, Hansell NK, Hariri AR, Ikram MK, Jukema JW, Vuoksimaa E, Keller MC, Kremen WS, Launer L, Lindenberger U, Palotie A, Pedersen NL, Pendleton N, Porteous DJ, Raikkonen K, Raitakari OT, Ramirez A, Reinvang I, Rudan I, Dan R, Schmidt R, Schmidt H, Schofield PW, Schofield PR, Starr JM, Steen VM, Trollor JN, Turner ST, Van Duijn CM, Villringer A, Weinberger DR, Weir DR, Wilson JF, Malhotra A, McIntosh AM, Gale CR, Seshadri S, Mosley TH Jr, Bressler J, Lencz T, Deary IJ (2018) Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun 9(1):2098. https://doi.org/10.1038/s41467-018-04362-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sniekers S, Stringer S, Watanabe K, Jansen PR, Coleman JRI, Krapohl E, Taskesen E, Hammerschlag AR, Okbay A, Zabaneh D, Amin N, Breen G, Cesarini D, Chabris CF, Iacono WG, Ikram MA, Johannesson M, Koellinger P, Lee JJ, Magnusson PKE, McGue M, Miller MB, Ollier WER, Payton A, Pendleton N, Plomin R, Rietveld CA, Tiemeier H, van Duijn CM, Posthuma D (2017) Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence. Nat Genet 49(10):1558. https://doi.org/10.1038/ng1017-1558c

Article  CAS  PubMed  Google Scholar 

Benyamin B, Pourcain B, Davis OS, Davies G, Hansell NK, Brion MJ, Kirkpatrick RM, Cents RA, Franic S, Miller MB, Haworth CM, Meaburn E, Price TS, Evans DM, Timpson N, Kemp J, Ring S, McArdle W, Medland SE, Yang J, Harris SE, Liewald DC, Scheet P, Xiao X, Hudziak JJ et al (2014) Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Mol Psychiatry 19(2):253–258. https://doi.org/10.1038/mp.2012.184

Article  CAS  PubMed  Google Scholar 

Mollon J, Knowles EEM, Mathias SR, Gur R, Peralta JM, Weiner DJ, Robinson EB, Gur RE, Blangero J, Almasy L, Glahn DC (2021) Genetic influence on cognitive development between childhood and adulthood. Mol Psychiatry 26(2):656–665. https://doi.org/10.1038/s41380-018-0277-0

Article  PubMed  Google Scholar 

Bougma K, Aboud FE, Harding KB, Marquis GS (2013) Iodine and mental development of children 5 years old and under: a systematic review and meta-analysis. Nutrients 5(4):1384–1416. https://doi.org/10.3390/nu5041384

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gordon RC, Rose MC, Skeaff SA, Gray AR, Morgan KM, Ruffman T (2009) Iodine supplementation improves cognition in mildly iodine-deficient children. Am J Clin Nutr 90(5):1264–1271. https://doi.org/10.3945/ajcn.2009.28145

Article  CAS  PubMed  Google Scholar 

Zimmermann MB, Connolly K, Bozo M, Bridson J, Rohner F, Grimci L (2006) Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study. Am J Clin Nutr 83(1):108–114. https://doi.org/10.1093/ajcn/83.1.108

Article  CAS  PubMed  Google Scholar 

Maher BS (2015) Polygenic scores in epidemiology: risk prediction, etiology, and clinical utility. Curr Epidemiol Rep 2(4):239–244. https://doi.org/10.1007/s40471-015-0055-3

Article  PubMed  PubMed Central  Google Scholar 

Kroke A, Manz F, Kersting M, Remer T, Sichert-Hellert W, Alexy U, Lentze MJ (2004) The DONALD Study History, current status and future perspectives. Eur J Nutr 43(1):45–54. https://doi.org/10.1007/s00394-004-0445-7

Article  PubMed  Google Scholar 

Buyken AE, Alexy U, Kersting M, Remer T (2012) The DONALD cohort An updated overview on 25 years of research based on the Dortmund Nutritional and Anthropometric Longitudinally Designed study. Bundesgesundheitsblatt Gesundheit Gesundheit 55(6–7):875–884. https://doi.org/10.1007/s00103-012-1503-6

Article  CAS  Google Scholar 

Weiß RH, Osterland J (2013) CFT 1-R: Grundintelligenztest Skala 1. Hogrefe, Göttingen

Google Scholar 

Weiß RH (2006) CFT 20-R: Grundintelligenztest Skala 2. Hogrefe, Göttingen

Google Scholar 

Remer T, Hua Y, Esche J, Thamm M (2022) The DONALD study as a longitudinal sensor of nutritional developments: iodine and salt intake over more than 30 years in German children. Eur J Nutr. https://doi.org/10.1007/s00394-022-02801-6

Article  PubMed  PubMed Central  Google Scholar 

Remer T, Neubert A, Maser-Gluth C (2002) Anthropometry-based reference values for 24-h urinary creatinine excretion during growth and their use in endocrine and nutritional research. Am J Clin Nutr 75(3):561–569. https://doi.org/10.1093/ajcn/75.3.561

Article  CAS  PubMed  Google Scholar 

Johner SA, Thamm M, Nothlings U, Remer T (2013) Iodine status in preschool children and evaluation of major dietary iodine sources: a German experience. Eur J Nutr 52(7):1711–1719. https://doi.org/10.1007/s00394-012-0474-6

Article  CAS  PubMed  Google Scholar 

Remer T, Montenegro-Bethancourt G, Shi LJ (2014) Long-term urine biobanking: Storage stability of clinical chemical parameters under moderate freezing conditions without use of preservatives. Clin Biochem 47(18):307–311. https://doi.org/10.1016/j.clinbiochem.2014.09.009

Article  CAS  PubMed  Google Scholar 

Lorenz-Wawschinek OTB, Eber O, Langsteger W (1994) Photometric determination of iodine in urine. Exp Clin Endocrinol 102:2

Google Scholar 

Ittermann T, Johner S, Below H, Leiterer M, Thamm M, Remer T, Volzke H (2018) Interlaboratory variability of urinary iodine measurements. Clin Chem Lab Med 56(3):441–447. https://doi.org/10.1515/cclm-2017-0580

Article  CAS  PubMed  Google Scholar 

Trumbo P, Yates AA, Schlicker S, Poos M (2001) Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Am Diet Assoc 101(3):294–301. https://doi.org/10.1016/S0002-8223(01)00078-5

Article  CAS  PubMed  Google Scholar 

McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, Kang HM, Fuchsberger C, Danecek P, Sharp K, Luo Y, Sidore C, Kwong A, Timpson N, Koskinen S, Vrieze S, Scott LJ, Zhang H, Mahajan A, Veldink J, Peters U, Pato C, van Duijn CM, Gillies CE, Gandin I, Mezzavilla M, Gilly A, Cocca M, Traglia M, Angius A, Barrett JC, Boomsma D, Branham K, Breen G, Brummett CM, Busonero F, Campbell H, Chan A, Chen S, Chew E, Collins FS, Corbin LJ, Smith GD, Dedoussis G, Dorr M, Farmaki AE, Ferrucci L, Forer L, Fraser RM, Gabriel S, Levy S, Groop L, Harrison T, Hattersley A, Holmen OL, Hveem K, Kretzler M, Lee JC, McGue M, Meitinger T, Melzer D, Min JL, Mohlke KL, Vincent JB, Nauck M, Nickerson D, Palotie A, Pato M, Pirastu N, McInnis M, Richards JB, Sala C, Salomaa V, Schlessinger D, Schoenherr S, Slagboom PE, Small K, Spector T, Stambolian D, Tuke M, Tuomilehto J, Van den Berg LH, Van Rheenen W, Volker U, Wijmenga C, Toniolo D, Zeggini E, Gasparini P, Sampson MG, Wilson JF, Frayling T, de Bakker PI, Swertz MA, McCarroll S, Kooperberg C, Dekker A, Altshuler D, Willer C, Iacono W, Ripatti S, Soranzo N, Walter K, Swaroop A, Cucca F, Anderson CA, Myers RM, Boehnke M, McCarthy MI, Durbin R, Haplotype Reference C (2016) A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet 48(10):1279–1283. https://doi.org/10.1038/ng.3643

Article  CAS  PubMed  PubMed Central  Google Scholar 

Loh PR, Danecek P, Palamara PF, Fuchsberger C et al (2016) Reference-based phasing using the Haplotype Reference Consortium panel. Nat Genet 48(11):1443–1448. https://doi.org/10.1038/ng.3679

Article  CAS  PubMed  PubMed Central  Google Scholar 

Team RC (2019) R: A language and environment for statistical computing. R Foundation for Statistical

Zimmermann MB (2012) The effects of iodine deficiency in pregnancy and infancy. Paediatr Perinat Epidemiol 26(Suppl 1):108–117. https://doi.org/10.1111/j.1365-3016.2012.01275.x

Article  PubMed  Google Scholar 

Qian M, Wang D, Watkins WE, Gebski V, Yan YQ, Li M, Chen ZP (2005) The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China. Asia Pac J Clin Nutr 14(1):32–42

CAS  PubMed  Google Scholar 

Haworth CM, Wright MJ, Luciano M, Martin NG, de Geus EJ, van Beijsterveldt CE, Bartels M, Posthuma D, Boomsma DI, Davis OS, Kovas Y, Corley RP, Defries JC, Hewitt JK, Olson RK, Rhea SA, Wadsworth SJ, Iacono WG, McGue M, Thompson LA, Hart SA, Petrill SA, Lubinski D, Plomin R (2010) The heritability of general cognitive ability increases linearly from childhood to young adulthood. Mol Psychiatry 15(11):1112–1120. https://doi.org/10.1038/mp.2009.55

Article  CAS  PubMed  Google Scholar 

WHO (2007) Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. WHO Press

Johner SA, Gunther AL, Remer T (2011) Current trends of 24-h urinary iodine excretion in German schoolchildren and the importance of iodised salt in processed foods. Br J Nutr 106(11):1749–1756. https://doi.org/10.1017/S0007114511005502

Article  CAS  PubMed