American Diabetes Association Professional Practice Committee. 2. Classification and diagnosis of diabetes: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022;45(Suppl 1):17–S38.

Article  Google Scholar 

Vokó Z, Gáspár K, Inotai A, Horváth C, Bors K, Speer G, et al. Osteoporotic fractures may impair life as much as the complications of diabetes. J Eval Clin Pract. 2017;23(6):1375–80.

Article  PubMed  Google Scholar 

Chandran M, Tay D, Huang XF, Hao Y. The burden of inpatient care for diabetic and non-diabetic patients with osteoporotic hip fractures-does it differ? An analysis of patients recruited into a fracture liaison service in Southeast Asia. Arch Osteoporos. 2018;13(1):27.

Article  CAS  PubMed  Google Scholar 

Huang X, Li S, Lu W, Xiong L. Metformin activates Wnt/β-catenin for the treatment of diabetic osteoporosis. BMC Endocr Disord. 2022;22(1):189.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gassel LC, Schneider S, Banke IJ, Braun KF, Volkering C, Zeeb L, et al. Dysregulation of wnt signaling in bone of type 2 diabetes mellitus and diabetic Charcot arthropathy. BMC Musculoskelet Disord. 2022;23(1):365.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cosin-Roger J, Ortiz-Masià MD, Barrachina MD. Macrophages as an emerging source of wnt ligands: relevance in Mucosal Integrity. Front Immunol. 2019;10:2297.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Yuan X, Arioka M, Bahat D, Sun Q, Chen J, et al. Pro-osteogenic Effects of WNT in a mouse model of bone formation around femoral implants. Calcif Tissue Int. 2021;108(2):240–51.

Article  CAS  PubMed  Google Scholar 

Appelman-Dijkstra NM, Papapoulos SE. Clinical advantages and disadvantages of anabolic bone therapies targeting the WNT pathway. Nat Rev Endocrinol. 2018;14(10):605–23.

Article  CAS  PubMed  Google Scholar 

Janssen R, Pechmann M, Turetzek N. A chelicerate wnt gene expression atlas: novel insights into the complexity of arthropod wnt-patterning. Evodevo. 2021;9(1):12.

Article  Google Scholar 

Yin P, Wang W, Zhang Z, Bai Y, Gao J, Zhao C. Wnt signaling in human and mouse breast cancer: focusing on wnt ligands, receptors and antagonists. Cancer Sci. 2018;109(11):3368–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kessenbrock K, Smith P, Steenbeek SC, Pervolarakis N, Kumar R, Minami Y, et al. Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical wnt signaling. Proc Natl Acad Sci U S A. 2017;114(12):3121–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nusse R, Clevers H. Wnt/β-Catenin signaling, Disease, and emerging therapeutic modalities. Cell. 2017;169(6):985–99.

Article  CAS  PubMed  Google Scholar 

Nie X, Wei X, Ma H, Fan L, Chen WD. The complex role of wnt ligands in type 2 diabetes mellitus and related complications. J Cell Mol Med. 2021;25(14):6479–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lojk J, Marc J. Roles of non-canonical wnt signalling Pathways in Bone Biology. Int J Mol Sci. 2021;22(19):10840.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ackers I, Malgor R. Interrelationship of canonical and non-canonical wnt signalling pathways in chronic metabolic diseases. Diab Vasc Dis Res. 2018;15(1):3–13.

Article  CAS  PubMed  Google Scholar 

Chen H, Huang H, Wang Y, Zhang Y, Liu M, Lou Y, et al. Decreased serum wnt antagonist levels in patients with active acromegaly. Endocr Pract. 2022;28(5):515–20.

Article  PubMed  Google Scholar 

Choi RB, Robling AG. The wnt pathway: an important control mechanism in bone’s response to mechanical loading. Bone. 2021;153:116087.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baksh D, Tuan RS. Canonical and non-canonical wnts differentially affect the development potential of primary isolate of human bone marrow mesenchymal stem cells. J Cell Physiol. 2007;212(3):817–26.

Article  CAS  PubMed  Google Scholar 

Alharbi MA, Zhang C, Lu C, Milovanova TN, Yi L, Ryu JD, et al. FOXO1 deletion reverses the Effect of Diabetic-Induced impaired Fracture Healing. Diabetes. 2018;67(12):2682–94.

Article  PubMed  PubMed Central  Google Scholar 

Yang J, Chen S, Zong Z, Yang L, Liu D, Bao Q, et al. The increase in bone resorption in early-stage type I diabetic mice is induced by RANKL secreted by increased bone marrow adipocytes. Biochem Biophys Res Commun. 2020;525(2):433–9.

Article  CAS  PubMed  Google Scholar 

Morinaga H, Muta Y, Tanaka T, Tanabe M, Hamaguchi Y, Yanase T. High-mobility group box 2 protein is essential for the early phase of adipogenesis. Biochem Biophys Res Commun. 2021;557:97–103.

Article  CAS  PubMed  Google Scholar 

Arnold KM, Pohlig RT, Sims-Mourtada J. Co-activation of hedgehog and wnt signaling pathways is associated with poor outcomes in triple negative breast cancer. Oncol Lett. 2017;14(5):5285–92.

PubMed  PubMed Central  Google Scholar 

He J, Zhang N, Zhang J, Jiang B, Wu F. Migration critically meditates osteoblastic differentiation of bone mesenchymal stem cells through activating canonical wnt signal pathway. Colloids Surf B Biointerfaces. 2018;171:205–13.

Article  CAS  PubMed  Google Scholar 

Nelson AL, Fontana G, Miclau E, Rongstad M, Murphy W, Huard J, et al. Therapeutic approaches to activate the canonical wnt pathway for bone regeneration. J Tissue Eng Regen Med. 2022;16(11):961–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang B, Rong X, Zhou Y, Liu Y, Sun J, Zhao B, et al. Eukaryotic initiation factor 4A3 inhibits Wnt/β-catenin signaling and regulates axis formation in zebrafish embryos. Development. 2021;148(9):dev198101.

Article  CAS  PubMed  Google Scholar 

Puzik K, Tonnier V, Opper I, Eckert A, Zhou L, Kratzer MC, et al. Lef1 regulates caveolin expression and caveolin dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling during Xenopus gastrulation. Sci Rep. 2019;9(1):15645.

Article  PubMed  PubMed Central  Google Scholar 

Cruciat CM, Niehrs C. Secreted and transmembrane wnt inhibitors and activators. Cold Spring Harb Perspect Biol. 2013;5(3):a015081.

Article  PubMed  PubMed Central  Google Scholar 

Du JH, Lin SX, Wu XL, Yang SM, Cao LY, Zheng A, et al. The function of wnt ligands on Osteocyte and Bone Remodeling. J Dent Res. 2019;98(8):930–8.

Article  CAS  PubMed  Google Scholar 

Lawson LY, Brodt MD, Migotsky N, Chermside-Scabbo CJ, Palaniappan R, Silva MJ. Osteoblast-specific wnt secretion is required for skeletal Homeostasis and Loading-Induced bone formation in adult mice. J Bone Miner Res. 2022;37(1):108–20.

Article  CAS  PubMed  Google Scholar 

Zhang B, Li R, Wang W, Zhou X, Luo B, Zhu Z, et al. Effects of WNT1 c.110 T > C and c.505G > T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathway. J Orthop Surg Res. 2021;16(1):359.

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Chen L, Yin Q, Gao H, Dong P, Zhang X, et al. Reciprocal interferences of TNF-α and Wnt1/β-catenin signaling axes shift bone marrow-derived stem cells towards osteoblast lineage after ethanol exposure. Cell Physiol Biochem. 2013;32(3):755–65.

Article  CAS  PubMed  Google Scholar 

Zhang D, Xiao W, Liu C, Wang Z, Liu Y, Yu Y, et al. Exosomes derived from adipose stem cells enhance Bone Fracture Healing via the activation of the Wnt3a/β-Catenin signaling pathway in rats with type 2 diabetes Mellitus. Int J Mol Sci. 2023;24(5):4852.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fushimi S, Nohno T, Nagatsuka H, Katsuyama H. Involvement of mir-140-3p in Wnt3a and TGFβ3 signaling pathways during osteoblast differentiation in MC3T3-E1 cells. Genes Cells. 2018;23(7):517–27.

Article  CAS  PubMed  Google Scholar 

Liu H, Zhang N, Liu Y, Liu L, Yin G, En L. Effect of human Wnt10b transgene overexpression on Peri-Implant Osteogenesis in Ovariectomized rats. Hum Gene Ther. 2018;29(12):1416–27.

Article  CAS  PubMed  Google Scholar 

Li Q, Li C, Xi S, Li X, Ding L, Li M. The effects of photobiomodulation therapy on mouse pre-osteoblast cell line MC3T3-E1 proliferation and apoptosis via miR-503/Wnt3a pathway. Lasers Med Sci. 2019;34(3):607–14.

Article  PubMed  Google Scholar 

Wang F, Rummukainen P, Heino TJ, Kiviranta R. Osteoblastic Wnt1 regulates periosteal bone formation in adult mice. Bone. 2021;143:115754.