Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, Fishman SJ, Boyd TK, Kozakewich HPW, Bischoff J, Greene AK, Warman ML. Somatic activating mutations in GNAQ and GNA11 are Associated with congenital hemangioma. Am J Hum Genet. 2016;98:1271.

Article  Google Scholar 

Enjolras O, Mulliken JB, Boon LM, Wassef M, Kozakewich HP, Burrows PE. Noninvoluting congenital hemangioma: a rare cutaneous vascular anomaly. Plast Reconstr Surg. 2001;107:1647–54.

Article  Google Scholar 

Hua C, Wang L, Jin Y, Chen H, Ma G, Gong X, Qiu Y, Yang X, Ying H, Lin X. A case series of tardive expansion congenital hemangioma: a variation of noninvoluting congenital hemangioma or a new hemangiomatous entity? J Am Acad Dermatol. 2021;84:1371–7.

Article  Google Scholar 

Tripathi R, Mazmudar RS, Knusel KD, Ezaldein HH, Belazarian LT, Bordeaux JS, Scott JF. Impact of congenital cutaneous hemangiomas on newborn care in the United States. Arch Dermatol Res. 2021;313:641–51.

Article  Google Scholar 

Boon LM, Enjolras O, Mulliken JB. Congenital hemangioma: evidence of accelerated involution. J Pediatr. 1996;128:329–35.

Article  Google Scholar 

Mulliken JB, Enjolras O. Congenital hemangiomas and infantile hemangioma: missing links. J Am Acad Dermatol. 2004;50:875–82.

Article  Google Scholar 

Vildy S, Macher J, Abasq-Thomas C, Le Rouzic-Dartoy C, Brunelle F, Hamel-Teillac D, Duteille F, Perret C, Perrot P, Cassagnau E, Chauty-Frondas A, Aubert H, Barbarot S. Life-threatening hemorrhaging in neonatal ulcerated congenital hemangioma: two case reports. JAMA Dermatol. 2015;151:422–5.

Article  Google Scholar 

O’Connell L, Winter DC, Organoids. Past learning and future directions. Stem Cells Dev. 2020;29:281–9.

Article  Google Scholar 

Kamb A. What’s wrong with our cancer models? Nat Rev Drug Discov. 2005;4:161–5.

Article  Google Scholar 

Yang L, Yang S, Li X, Li B, Li Y, Zhang X, Ma Y, Peng X, Jin H, Fan Q, Wei S, Liu J, Li H. Tumor organoids: from inception to future in cancer research. Cancer Lett. 2019;454:120–33.

Article  Google Scholar 

Rossi G, Manfrin A, Lutolf MP. Progress and potential in organoid research. Nat Rev Genet. 2018;19:671–87.

Article  Google Scholar 

Wang S, Gao D, Chen Y. The potential of organoids in urological cancer research. Nat Rev Urol. 2017;14:401–14.

Article  Google Scholar 

Mun SJ, Ryu JS, Lee MO, Son YS, Oh SJ, Cho HS, Son MY, Kim DS, Kim SJ, Yoo HJ, Lee HJ, Kim J, Jung CR, Chung KS, Son MJ. Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids. J Hepatol. 2019;71:970–85.

Article  Google Scholar 

Gabriel E, Albanna W, Pasquini G, Ramani A, Josipovic N, Mariappan A, Schinzel F, Karch CM, Bao G, Gottardo M, Suren AA, Hescheler J, Nagel-Wolfrum K, Persico V, Rizzoli SO, Altmuller J, Riparbelli MG, Callaini G, Goureau O, Papantonis A, Busskamp V, Schneider T, Gopalakrishnan J. Human brain organoids assemble functionally integrated bilateral optic vesicles. Cell Stem Cell. 2021;28:1740–1757e1748.

Article  Google Scholar 

Li Y, Zhu X, Kong M, Chen S, Bao J, Ji Y. Three-Dimensional Microtumor Formation of Infantile Hemangioma-Derived Endothelial Cells for Mechanistic Exploration and Drug Screening. Pharmaceuticals (Basel) 2022, 15.

Gong X, Li Y, Yang K, Chen S, Ji Y. Infantile hepatic hemangiomas: looking backwards and forwards. Precis Clin Med. 2022;5:pbac006.

Article  Google Scholar 

Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139–40.

Article  Google Scholar 

Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16:284–7.

Article  Google Scholar 

Kopper O, de Witte CJ, Lohmussaar K, Valle-Inclan JE, Hami N, Kester L, Balgobind AV, Korving J, Proost N, Begthel H, van Wijk LM, Revilla SA, Theeuwsen R, van de Ven M, van Roosmalen MJ, Ponsioen B, Ho VWH, Neel BG, Bosse T, Gaarenstroom KN, Vrieling H, Vreeswijk MPG, van Diest PJ, Witteveen PO, Jonges T, Bos JL, van Oudenaarden A, Zweemer RP, Snippert HJG, Kloosterman WP, Clevers H. An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity. Nat Med. 2019;25:838–49.

Article  Google Scholar 

Yan HHN, Siu HC, Law S, Ho SL, Yue SSK, Tsui WY, Chan D, Chan AS, Ma S, Lam KO, Bartfeld S, Man AHY, Lee BCH, Chan ASY, Wong JWH, Cheng PSW, Chan AKW, Zhang J, Shi J, Fan X, Kwong DLW, Mak TW, Yuen ST, Clevers H, Leung SY. A Comprehensive Human gastric Cancer Organoid Biobank captures Tumor Subtype Heterogeneity and enables therapeutic screening. Cell Stem Cell. 2018;23:882–897e811.

Article  Google Scholar 

Hacker BC, Gomez JD, Batista CAS, Rafat M. Growth and Characterization of Irradiated Organoids from Mammary Glands.J Vis Exp2019.

Huo CW, Huang D, Chew GL, Hill P, Vohora A, Ingman WV, Glynn DJ, Godde N, Henderson MA, Thompson EW, Britt KL. Human glandular organoid formation in murine engineering chambers after collagenase digestion and flow cytometry isolation of normal human breast tissue single cells. Cell Biol Int. 2016;40:1212–23.

Article  Google Scholar 

Jowett GM, Norman MDA, Yu TTL, Rosell Arevalo P, Hoogland D, Lust ST, Read E, Hamrud E, Walters NJ, Niazi U, Chung MWH, Marciano D, Omer OS, Zabinski T, Danovi D, Lord GM, Hilborn J, Evans ND, Dreiss CA, Bozec L, Oommen OP, Lorenz CD, da Silva RMP, Neves JF. Gentleman, E. ILC1 drive intestinal epithelial and matrix remodelling. Nat Mater. 2021;20:250–9.

Article  Google Scholar 

Miura S, Suzuki A. Generation of mouse and human organoid-forming intestinal progenitor cells by direct lineage reprogramming. Cell Stem Cell. 2017;21:456–471e455.

Article  Google Scholar 

Kruitwagen HS, Oosterhoff LA, Vernooij I, Schrall IM, van Wolferen ME, Bannink F, Roesch C, van Uden L, Molenaar MR, Helms JB, Grinwis GCM, Verstegen MMA, van der Laan LJW, Huch M, Geijsen N, Vries RG, Clevers H, Rothuizen J, Schotanus BA, Penning LC, Spee B. Long-term adult feline liver organoid cultures for Disease modeling of hepatic steatosis. Stem Cell Reports. 2017;8:822–30.

Article  Google Scholar 

Putra J, Gupta A. Kaposiform haemangioendothelioma: a review with emphasis on histological differential diagnosis. Pathology. 2017;49:356–62.

Article  Google Scholar 

Hung TW, Chu CY, Yu CL, Lee CC, Hsu LS, Chen YS, Hsieh YH, Tsai JP. Endothelial Cell-Specific Molecule 1 Promotes Endothelial to Mesenchymal Transition in Renal Fibrosis. Toxins (Basel) 2020, 12.

Ren N, Jin CS, Zhao XQ, Gao WH, Gao YX, Wang Y, Zhang YF. Preterm neonate with a large congenital hemangioma on maxillofacial site causing thrombocytopenia and heart failure: a case report. World J Clin Cases. 2022;10:5756–63.

Article  Google Scholar 

Aboulkheyr Es H, Montazeri L, Aref AR, Vosough M, Baharvand H. Personalized Cancer Medicine: an Organoid Approach. Trends Biotechnol. 2018;36:358–71.

Article  Google Scholar 

Veninga V, Voest EE. Tumor organoids: Opportunities and challenges to guide precision medicine. Cancer Cell. 2021;39:1190–201.

Article  Google Scholar 

Xu R, Zhou X, Wang S, Trinkle C. Tumor organoid models in precision medicine and investigating cancer-stromal interactions. Pharmacol Ther. 2021;218:107668.

Article  Google Scholar 

Cohen-Cutler S, Szymanski LJ, Bockoven C, Miller JM, Moke D, Anselmo DM, Lee J, Luu M. Catastrophic congenital hemangioma with severe coagulopathy leading to fatal cardiac failure: case report and review. Pediatr Dermatol. 2021;38:1276–82.

Article  Google Scholar 

Olsen GM, Nackers A, Drolet BA. Infantile and congenital hemangiomas. Semin Pediatr Surg. 2020;29:150969.

Article  Google Scholar 

Nasseri E, Piram M, McCuaig CC, Kokta V, Dubois J, Powell J. Partially involuting congenital hemangiomas: a report of 8 cases and review of the literature. J Am Acad Dermatol. 2014;70:75–9.

Article  Google Scholar 

Kieran I, Zakaria Z, Kaliaperumal C, O’Rourke D, O’Hare A, Laffan E, Caird J, King MD, Murray DJ. Possible toxicity following embolization of congenital giant vertex hemangioma: case report. J Neurosurg Pediatr. 2017;19:296–9.

Article  Google Scholar 

Movassaghi M, Wu J, Carpenter CP. Pediatric Penile non-involuting congenital Hemangioma with an Associated Pyogenic Granuloma: Surgical Management of a rare vascular anomaly. Urology. 2021;158:197–9.

Article  Google Scholar 

Triana P, Rodriguez-Laguna L, Giacaman A, Salinas-Sanz JA, Martin-Santiago A, Lopez-Santamaria M, Palacios E, Beato MJ, Martinez-Gonzalez V, Lopez-Gutierrez JC. Congenital hepatic hemangiomas: clinical, histologic, and genetic correlation. J Pediatr Surg. 2020;55:2170–6.

Article  Google Scholar 

Funk T, Lim Y, Kulungowski AM, Prok L, Crombleholme TM, Choate K, Bruckner AL. Symptomatic congenital hemangioma and congenital hemangiomatosis Associated with a somatic activating mutation in GNA11. JAMA Dermatol. 2016;152:1015–20.

Article  Google Scholar 

Chen X, Wu Q, Tan L, Porter D, Jager MJ, Emery C, Bastian BC. Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations. Oncogene. 2014;33:4724–34.

Article  Google Scholar 

Lackner H, Karastaneva A, Schwinger W, Benesch M, Sovinz P, Seidel M, Sperl D, Lanz S, Haxhija E, Reiterer F, Sorantin E, Urban CE. Sirolimus for the treatment of children with various complicated vascular anomalies. Eur J Pediatr. 2015;174:1579–84.

Article  Google Scholar 

Nguyen HL, Boon LM, Vikkula M. Vascular Anomalies caused by abnormal signaling within endothelial cells: targets for Novel Therapies. Semin Intervent Radiol. 2017;34:233–8.

Article  Google Scholar 

Ji Y, Chen S, Zhou J, Yang K, Zhang X, Xiang B, Qiu T, Gong X, Zhang Z, Lan Y, Hu F, Kong F, Qiu Q, Zhang Y. Sirolimus plus prednisolone vs sirolimus monotherapy for kaposiform hemangioendothelioma: a randomized clinical trial. Blood. 2022;139:1619–30.

Article  Google Scholar 

Ji Y, Chen S, Yang K, Zhou J, Zhang X, Jiang X, Xu X, Lu G, Qiu L, Kong F, Zhang Y. A prospective multicenter study of sirolimus for complicated vascular anomalies. J Vasc Surg. 2021;74:1673–1681e1673.

Article  Google Scholar