Daniel TM, Bates JH, Downes KA. History of tuberculosis. Tuberculosis: pathogenesis protection and control 1994:13–24.

Barberis I, Bragazzi NL, Galluzzo L, Martini M. The history of tuberculosis: from the first historical records to the isolation of Koch’s bacillus. J Prev Med Hyg. 2017;58(1):E9.

CAS  PubMed  PubMed Central  Google Scholar 

Gagneux S. Ecology and evolution of Mycobacterium tuberculosis. Nat Rev Microbiol. 2018;16(4):202–13.

Article  CAS  PubMed  Google Scholar 

WHO. : Global tuberculosis report In. Geneva; 2021.

Golden MP, Vikram HR. Extrapulmonary tuberculosis: an overview. Am Fam Physician. 2005;72(9):1761–8.

PubMed  Google Scholar 

Gopalaswamy R, Dusthackeer VA, Kannayan S, Subbian S. Extrapulmonary tuberculosis—an update on the diagnosis, treatment and drug resistance. J Respir. 2021;1(2):141–64.

Article  Google Scholar 

Varghese B, Al-Hajoj S. Mapping the epidemiology and trends of extra-pulmonary tuberculosis in Saudi Arabia. Int J Mycobacteriol 2015, 4(4):261–9.

Katsnelson A. Beyond the breath: exploring sex differences in tuberculosis outside the lungs. Nat Med. 2017;23(4):398–402.

Article  CAS  PubMed  Google Scholar 

Ganchua SKC, White AG, Klein EC, Flynn JL. Lymph nodes—the neglected battlefield in tuberculosis. PLoS pathog. 2020;16(8):e1008632.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alene KA, Clements AC. Spatial clustering of notified tuberculosis in Ethiopia: a nationwide study. PLoS ONE. 2019;14(8):e0221027.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tessema B, Muche A, Bekele A, Reissig D, Emmrich F, Sack U. Treatment outcome of tuberculosis patients at Gondar University Teaching Hospital, Northwest Ethiopia. A five-year retrospective study. BMC Public Health. 2009;9(1):1–8.

Article  Google Scholar 

Mekonnen D, Derbie A, Mekonnen H, Zenebe Y. Profile and treatment outcomes of patients with tuberculosis in northeastern Ethiopia: a cross sectional study. Afr Health Sci. 2016;16(3):663–70.

Article  PubMed  PubMed Central  Google Scholar 

Zenebe Y, Adem Y, Mekonnen D, Derbie A, Bereded F, Bantie M, et al. Profile of tuberculosis and its response to anti-TB drugs among tuberculosis patients treated under the TB control programme at Felege-Hiwot Referral Hospital, Ethiopia. BMC Public Health. 2016;16(1):1–8.

Article  Google Scholar 

Mekonnen D, Munshae A, Nibret E, Derbie A, Abeje A, Feleke BE et al. Tuberculosis case notification rate mapping in Amhara Regional State, Ethiopia: Four years retrospective study: Tuberculosis. EMJ 2022, 60(01).

Berg S, Schelling E, Hailu E, Firdessa R, Gumi B, Erenso G, et al. Investigation of the high rates of extrapulmonary tuberculosis in Ethiopia reveals no single driving factor and minimal evidence for zoonotic transmission of Mycobacterium bovis infection. BMC Infect Dis. 2015;15:112.

Article  PubMed  PubMed Central  Google Scholar 

Firdessa R, Berg S, Hailu E, Schelling E, Gumi B, Erenso G, et al. Mycobacterial lineages causing pulmonary and extrapulmonary tuberculosis, Ethiopia. Emerg Infect Dis. 2013;19(3):460.

Article  PubMed  PubMed Central  Google Scholar 

Mekonnen D, Derbie A, Abeje A, Shumet A, Nibret E, Biadglegne F, et al. Epidemiology of tuberculous lymphadenitis in Africa: a systematic review and meta-analysis. PLoS ONE. 2019;14(4):e0215647.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iwnetu R, Van Den Hombergh J, Woldeamanuel Y, Asfaw M, Gebrekirstos C, Negussie Y, et al. Is tuberculous lymphadenitis over-diagnosed in Ethiopia? Comparative performance of diagnostic tests for mycobacterial lymphadenitis in a high-burden country. Scand J Infect Dis. 2009;41(6–7):462–8.

Article  PubMed  Google Scholar 

Ameni G, Vordermeier M, Firdessa R, Aseffa A, Hewinson G, Gordon SV, et al. Mycobacterium tuberculosis infection in grazing cattle in central Ethiopia. Vet J. 2011;188(3–4):359–61.

Article  PubMed  PubMed Central  Google Scholar 

Qian X, Nguyen DT, Lyu J, Albers AE, Bi X, Graviss EA. Risk factors for extrapulmonary dissemination of tuberculosis and associated mortality during treatment for extrapulmonary tuberculosis. Emerg Microbes Infect. 2018;7(1):1–14.

Article  CAS  Google Scholar 

Asres A, Jerene D, Deressa W. Delays to anti-tuberculosis treatment intiation among cases on directly observed treatment short course in districts of southwestern Ethiopia: a cross sectional study. BMC Infect Dis. 2019;19:1–9.

Article  Google Scholar 

Awoke N, Dulo B, Wudneh F. Total delay in treatment of tuberculosis and associated factors among new pulmonary TB patients in selected health facilities of Gedeo zone, southern Ethiopia, 2017/18. Interdiscip Perspect Infect Dis 2019, 2019.

Bilchut AH, Mekonnen AG, Assen TA. Knowledge of symptoms and delays in diagnosis of extrapulmonary tuberculosis patients in North Shewa zone, Ethiopia. PLoS ONE. 2022;17(6):e0270002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shiferaw MB, Zegeye AM. Delay in tuberculosis diagnosis and treatment in Amhara state, Ethiopia. BMC Health Serv Res. 2019;19(1):1–8.

Article  Google Scholar 

Dakheel MA, Najaim AM, Moslah AM, Buni HD. The disseminated tuberculosis with cavitary lung lesion and tuberculoma in a six-month-old libyan infant. J Infect Dev Ctries. 2021;15(12):1929–32.

Article  PubMed  Google Scholar 

Lu M, Lai C, Tsai C, Koo M, Lai N. Increased risk of pulmonary and extra-pulmonary tuberculosis in patients with rheumatic diseases. IJTLD. 2015;19(12):1500–6.

Article  Google Scholar 

Abate E, Blomgran R, Verma D, Lerm M, Fredrikson M, Belayneh M, et al. Polymorphisms in CARD8 and NLRP3 are associated with extrapulmonary TB and poor clinical outcome in active TB in Ethiopia. Sci Rep. 2019;9(1):1–6.

Article  CAS  Google Scholar 

Samb B, Sow P, Kony S, Maynart-Badiane M, Diouf G, Cissokho S, et al. Risk factors for negative sputum acid-fast bacilli smears in pulmonary tuberculosis: results from Dakar, Senegal, a city with low HIV seroprevalence. IJTLD. 1999;3(4):330–6.

CAS  Google Scholar 

Hermosilla S, You P, Aifah A, Abildayev T, Akilzhanova A, Kozhamkulov U, et al. Identifying risk factors associated with smear positivity of pulmonary tuberculosis in Kazakhstan. PLoS ONE. 2017;12(3):e0172942.

Article  PubMed  PubMed Central  Google Scholar 

Maurya RK, Bharti S, Krishnan MY. Triacylglycerols: fuelling the hibernating Mycobacterium tuberculosis. Front Cell Infect Microbiol 2019:450.

Laval T, Chaumont L, Demangel C. Not too fat to fight: the emerging role of macrophage fatty acid metabolism in immunity to Mycobacterium tuberculosis. Immunol Rev. 2021;301(1):84–97.

Article  CAS  PubMed  Google Scholar 

Prabakaran JJ, Efrem B, Araya M, Mebrahtu M, Zeraburuk H, Yemane M, et al. Association of Dietary and serum cholesterol with active pulmonary tuberculosis: a Hospital based study. Int J Curr Microbiol App Sci. 2017;6(12):4056–73.

Article  Google Scholar 

Ahmed N, Amjad I, Malik ZA, Naseer A, Raza M, Imtiaz A et al. Effects of anti-tuberculosis drugs on lipid profile in pulmonary tuberculosis patients. JDUHS 2021.

Taparia P, Yadav D, Koolwal S, Mishra S. Study of lipid profile in pulmonary tuberculosis patients and relapse cases in relation with disease severity-A pilot study. Indian J Sci Appl Res. 2015;2:41–50.

Google Scholar 

Jo YS, Han K, Kim D, Yoo JE, Kim Y, Yang B, et al. Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort. Sci rep. 2021;11(1):1–9.

Article  Google Scholar 

Minardi ML, Fato I, Di Gennaro F, Mosti S, Mastrobattista A, Cerva C, et al. Common and rare hematological manifestations and adverse drug events during treatment of active TB: a state of art. Microorganisms. 2021;9(7):1477.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balepur SS, Schlossberg D. Hematologic complications of tuberculosis. Tuberculosis and Nontuberculous Mycobacterial Infections 2017:529–39.

Kirwan DE, Chong DL, Friedland JS. Platelet activation and the Immune response to tuberculosis. Front Immunol. 2021;12:1871.

Article  Google Scholar 

Kullaya V, van der Ven A, Mpagama S, Mmbaga BT, de Groot P, Kibiki G, et al. Platelet-monocyte interaction in Mycobacterium tuberculosis infection. Tuberculosis. 2018;111:86–93.

Article  CAS  PubMed  Google Scholar 

Alamlih L, Albakri M, Ibrahim WH, Khan A, Khan FY. Hematologic characteristics of patients with active pulmonary, extra-pulmonary and disseminated tuberculosis: a study of over six hundred patients. J Tuberc Res. 2020;8(02):33.

Article  CAS  Google Scholar 

Cobelens F, Kerkhoff AD. Tuberculosis and anemia—cause or effect? Environ Health Prev Med. 2021;26(1):1–2.

Article  Google Scholar 

Gelaw Y, Getaneh Z, Melku M. Anemia as a risk factor for tuberculosis: a systematic review and meta-analysis. Environ Health Prev Med. 2021;26(1):1–15.

Article  Google Scholar 

Davoudi S, Rasoolinegad M, Younesian M, Hajiabdolbaghi M, Soudbakhsh A, Jafari S, et al. CD4 + cell counts in patients with different clinical manifestations of tuberculosis. Braz J Infect Dis. 2008;12:483–6.

Article  PubMed  Google Scholar 

Bahir Dar City History., Demographics, Climate and Tourist Attractions [https://typicalethiopian.com/bahir-dar-city-history-demographics-climate-tourist-attractions/].

Bahir Dar City. [https://bahirdar.gov.et/index.php/en/city/people].

Thakar M, Angira F, Pattanapanyasat K, Wu AH, O’Gorman M, Zeng H, et al. CD4 lymphocyte enumeration and hemoglobin assessment aid for priority decisions: a multisite evaluation of the BD FACSPresto™ system. open AIDS J. 2017;11:76.

Article  PubMed  PubMed Central  Google Scholar 

Nuttall FQ. Body mass index: obesity, BMI, and health: a critical review. Nutr Today. 2015;50(3):117.

Article  PubMed  PubMed Central  Google Scholar 

A healthy lifestyle. : WHO recommendations. Available at https://www.who.int/europe/news-room/fact-sheets/item/a-healthy-lifestyle---who-recommendations.

WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. In.: World Health Organization; 2011.

Body mass index - BMI. [https://www.euro.who.int/en/health-topics/disease-prevention/nutrition/a-healthy-lifestyle/body-mass-index-bmi].

Lichtman MA, Kaushansky K, Prchal JT, Levi MM, Burns LJ, Armitage JO. Williams Manual of Hematology: Table of Normal Values. In: Williams Manual of Hematology, 9e edn. New York, NY: McGraw-Hill Education; 2017.

Mulu W, Abera B, Mekonnen Z, Adem Y, Yimer M, Zenebe Y, et al. Haematological and CD4 + T cells reference