Escaping the Long Shadow Cast by Agranulocytosis: Reflections on Clozapine Pharmacovigilance Focused on the United Kingdom

From the 1Mental Health Research Center, Eastern State Hospital, Lexington, KY

2Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria

3Department of Psychiatry, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain

4Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, UMR 1219, F-33000 Bordeaux, France

5Laboratory of Clinical Psychopharmacology

6The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China

7Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland

8The Zucker Hillside Hospital, Psychiatry Research, Northwell Health, Glen Oaks

9Department of Psychiatry, Zucker School of Medicine at Northwell/Hofstra, Hempstead, NY

10Department of Affective Disorders, Aarhus University Hospital—Psychiatry

11Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

12Dutch Clozapine Collaboration Group, Castricum

13FACT-team in Heerhugowaard, Department of Severe Mental Illness, Mental Health Services North–Holland North

14Mental Health Team Alkmaar, Mental Health Services Noord-Holland-Noord, Alkmaar, the Netherlands

15Department of Psychiatry, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea

16Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA

17Department of Pharmacy, Mayo Clinic, Rochester, MN

18Department of Psychiatry, Asahi General Hospital, Chiba, Japan

19Department of Clinical Pharmacology, Astrakhan State Medical University, Astrakhan, Russian Federation

20Department of Physiology, Los Andes University Medical School, Mérida, Venezuela

21Medical School, Anáhuac University

22Neuroorigen, Querétaro, México

23Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India

24Te Korowai Whāriki Central Regional Forensic Service, Capital and Coast District Health Board

25Department of Psychological Medicine, University of Otago, Wellington, New Zealand

26University of Adelaide, Discipline of Psychiatry, Adelaide, South Australia, Australia

27Department of Pharmacy Practice, University of Montana, Missoula, MT

28Instituto Vilapriño, Center for Studies, Assistance and Research in Neurosciences, Mendoza, Argentina

29Clinical Pharmacology Unit and Pharmacy Department, Vilardebó Hospital, Administración de Servicios de Salud, Montevideo, Uruguay

30Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland

31School of Medicine, University of Zagreb

32Department for Psychiatry and Psychological Medicine, University Hospital Center Zagreb, Croatia

33Department of Psychiatry, Hacettepe University Faculty of Medicine, Ankara, Turkey

34University of Kragujevac, Faculty of Medical Sciences, Department of Psychiatry, Kragujevac, Serbia

35National Institute of Mental Health, Neurology and Neurosurgery, Budapest, Hungary

36Department of Physical Medicine and Pharmacology, School of Medicine, Universidad de La Laguna, Canary Islands

37Hospital Universitario de Canarias, Tenerife

38Department of Internal Medicine, Dermatology and Psychiatry and Instituto Universitario de Neurociencia (IUNE), Universidad de La Laguna, La Laguna, Canary Islands, Spain.

Received October 29, 2022; accepted after revision January 18, 2023.

Address correspondence to: Jose de Leon, MD, Mental Health Research Center at Eastern State Hospital, 1350 Bull Lea Road, Lexington, KY 40511 (e-mail: [email protected]).

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