Cell entry and release of quasi-enveloped human hepatitis viruses

Balayan, M. S. et al. Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Intervirology 20, 23–31 (1983).

Article  CAS  PubMed  Google Scholar 

Feinstone, S. M., Kapikian, A. Z. & Purcell, R. H. Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness. Science 182, 1026–1028 (1973).

Article  CAS  PubMed  Google Scholar 

Lanford, R. E. et al. Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA. Proc. Natl Acad. Sci. USA 108, 11223–11228 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu, C. et al. Pathogenesis of hepatitis E virus and hepatitis C virus in chimpanzees: similarities and differences. J. Virol. 84, 11264–11278 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Purcell, R. H. et al. Pathobiology of hepatitis E: lessons learned from primate models. Emerg. Microbes Infect. 2, e9 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacobsen, K. H. Globalization and the changing epidemiology of hepatitis A virus. Cold Spring Harb. Perspect. Med. https://doi.org/10.1101/cshperspect.a031716 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Rein, D. B., Stevens, G. A., Theaker, J., Wittenborn, J. S. & Wiersma, S. T. The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology 55, 988–997 (2012).

Article  PubMed  Google Scholar 

Feng, Z. et al. A pathogenic picornavirus acquires an envelope by hijacking cellular membranes. Nature 496, 367–371 (2013). This is the first description of ESCRT-dependent release of quasi-enveloped hepatoviruses, showing that such virions are the only form of virus detectable in blood during acute hepatitis A, and describing post-endocytosis antibody-mediated neutralization of quasi-enveloped virus.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nagashima, S. et al. Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies. J. Gen. Virol. 95, 2166–2175 (2014). This study describes the ESCRT-dependent release of quasi-enveloped hepeviruses.

Article  PubMed  Google Scholar 

Feng, Z., Hirai-Yuki, A., McKnight, K. L. & Lemon, S. M. Naked viruses that aren’t always naked: quasi-enveloped agents of acute hepatitis. Annu. Rev. Virol. 1, 539–560 (2014).

Article  PubMed  Google Scholar 

McKnight, K. L. et al. Protein composition of the hepatitis A virus quasi-envelope. Proc. Natl Acad. Sci. USA 114, 6587–6592 (2017). This study identifies host proteins associated with purified quasi-enveloped hepatovirus, showing they are derived from multivesicular endosomes and that viral structural proteins are specifically sorted into vesicles for ESCRT-dependent release.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hessvik, N. P. & Llorente, A. Current knowledge on exosome biogenesis and release. Cell. Mol. Life Sci. 75, 193–208 (2018).

Article  CAS  PubMed  Google Scholar 

Hirai-Yuki, A., Whitmire, J. K., Joyce, M., Tyrrell, D. L. & Lemon, S. M. Murine models of hepatitis A virus infection. Cold Spring Harb. Perspect. Med. https://doi.org/10.1101/cshperspect.a031674 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Sayed, I. M. & Meuleman, P. Updates in hepatitis E virus (HEV) field; lessons learned from human liver chimeric mice. Rev. Med. Virol. 30, e2086 (2020).

Article  PubMed  Google Scholar 

Wang, M. & Feng, Z. Mechanisms of hepatocellular injury in hepatitis A. Viruses https://doi.org/10.3390/v13050861 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Yadav, K. K. & Kenney, S. P. Hepatitis E virus immunopathogenesis. Pathogens https://doi.org/10.3390/pathogens10091180 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Lemon, S. M., Ott, J. J., Van Damme, P. & Shouval, D. Type A viral hepatitis: a summary and update on the molecular virology, epidemiology, pathogenesis and prevention. J. Hepatol. 68, 167–184 (2018).

Article  CAS  Google Scholar 

Kamar, N., Dalton, H. R., Abravanel, F. & Izopet, J. Hepatitis E virus infection. Clin. Microbiol. Rev. 27, 116–138 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Kamar, N. & Pischke, S. Acute and persistent hepatitis E virus genotype 3 and 4 infection: clinical features, pathogenesis, and treatment. Cold Spring Harb. Perspect. Med. https://doi.org/10.1101/cshperspect.a031872 (2018).

Article  Google Scholar 

Hofmeister, M. G. et al. Hepatitis A person-to-person outbreaks: epidemiology, morbidity burden, and factors associated with hospitalization-multiple states, 2016–2019. J. Infect. Dis. 223, 426–434 (2021).

Article  PubMed  Google Scholar 

Ndumbi, P. et al. Hepatitis A outbreak disproportionately affecting men who have sex with men (MSM) in the European Union and European Economic Area, June 2016 to May 2017. Eur. Surveill. https://doi.org/10.2807/1560-7917.Es.2018.23.33.1700641 (2018).

Article  Google Scholar 

Nagashima, S. et al. Characterization of the quasi-enveloped hepatitis E virus particles released by the cellular exosomal pathway. J. Virol. https://doi.org/10.1128/jvi.00822-17 (2017). This report describes a sophisticated analysis of the morphology and structural components of cell culture-derived eHEV particles using electron microscopy and immune electron microscopy.

Article  PubMed  PubMed Central  Google Scholar 

Costafreda, M. I., Sauleda, S., Rico, A., Piron, M. & Bes, M. Detection of nonenveloped hepatitis E virus in plasma of infected blood donors. J. Infect. Dis. 226, 1753–1760 (2022).

Article  PubMed  Google Scholar 

Hirai-Yuki, A., Hensley, L., Whitmire, J. K. & Lemon, S. M. Biliary secretion of quasi-enveloped human hepatitis A virus. MBio 7, e01998–01916 (2016). This study demonstrates that bile acids strip the quasi-envelope from hepatoviruses released from the apical membrane of hepatocytes.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cullen, J. M. & Lemon, S. M. Comparative pathology of hepatitis A virus and hepatitis E virus infection. Cold Spring Harb. Perspect. Med. https://doi.org/10.1101/cshperspect.a033456 (2018).

Article  Google Scholar 

Hirai-Yuki, A. et al. MAVS-dependent host species range and pathogenicity of human hepatitis A virus. Science 353, 1541–1545 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Okamoto, H. Culture systems for hepatitis E virus. J. Gastroenterol. 48, 147–158 (2013).

Article  CAS  PubMed  Google Scholar 

Dao Thi, V. L. et al. Stem cell-derived polarized hepatocytes. Nat. Commun. 11, 1677 (2020). This study shows that bile acids secreted from the apical membrane of infected cells strip the quasi-envelope from hepevirus, resulting in release of naked virus.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marion, O. et al. Hepatitis E virus replication in human intestinal cells. Gut 69, 901–910 (2020).

Article  CAS  PubMed  Google Scholar 

Asher, L. V. S. et al. Pathogenesis of hepatitis A in orally inoculated owl monkeys (Aotus trivergatus). J. Med. Virol. 47, 260–268 (1995).

Article  CAS  PubMed  Google Scholar 

Takahashi, M. et al. Hepatitis E virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation. J. Clin. Microbiol. 48, 1112–1125 (2010). This report provides a detailed characterization of the physical properties of serum-derived hepevirus, demonstrating the masking of viral antigens by host membranes.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, X. et al. Hepatitis A virus and the origins of picornaviruses. Nature 517, 85–88 (2015).

Article  CAS  PubMed  Google Scholar 

Koonin, E. V., Dolja, V. V. & Krupovic, M. Origins and evolution of viruses of eukaryotes: the ultimate modularity. Virology 479–480, 2–25 (2015).

Article  PubMed  Google Scholar 

Kelly, A. G., Netzler, N. E. & White, P. A. Ancient recombination events and the origins of hepatitis E virus. BMC Evol. Biol. 16, 210 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Drexler, J. F. et al. Evolutionary origins of hepatitis A virus in small mammals. Proc. Natl Acad. Sci. USA 112, 15190–15195 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pavio, N., Meng, X. J. & Doceul, V. Zoonotic origin of hepatitis E. Curr. Opin. Virol. 10, 34–41 (2015).

Article  PubMed  Google Scholar 

Meng, X.-J. Expanding host range and cross-species infection of hepatitis E virus. PLoS Pathog. 12, e1005695 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Suppiah, S., Zhou, Y. & Frey, T. K. Lack of processing of the expressed ORF1 gene product of hepatitis E virus. Virol. J. 8, 245 (2011).

Article  CAS 

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