HPLC fingerprint of flavonoids, enzyme inhibition and antioxidant activity of Newbouldia laevis stem-bark: an in vitro and in silico study

Godman B, Basu D, Pillay Y, Mwita JC, Rwegerera GM, Anand BDP, Tiroyakgosi C, Okwen PM, Niba LL, Nonvignon J, Sefah I, Oluka M, Guantai AN, Kibuule D, Kalemeera F, Mubita M, Fadare J, Ogunleye OO, Distiller LA, Rampamba EM, Wing J, Mueller D, Alfadl A, Amu AA, Matsebula Z, Kalungia A, Zaranyika T, Masuka N, Wale J, Hill R, Kurdi A, Timoney A, Campbell S, Meyer JC (2020) Review of ongoing activities and challenges to improve the care of patients with type 2 diabetes across Africa and the implications for the future. Front Pharmacol 11:108. https://doi.org/10.3389/FPHAR.2020.00108

Article  PubMed  PubMed Central  Google Scholar 

Wang J, Li L, Wang Z, Cui Y, Tan X, Yuan T, Liu Q, Liu Z, Liu X (2018) Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress. J Nutr Biochem 56:16–25. https://doi.org/10.1016/J.JNUTBIO.2018.01.009

Article  CAS  PubMed  Google Scholar 

Diabetes Atlas, the seventh edition, 2015. http://www.diabetesatlas.org/resources/2015-atlas.html

Pollack RM, Donath MY, LeRoith D, Leibowitz G (2016) Anti-inflammatory agents in the treatment of diabetes and its vascular complications. Diabetes Care 39(Suppl 2):S244–S252. https://doi.org/10.2337/DCS15-3015

Article  CAS  PubMed  Google Scholar 

Akter K, Lanza EA, Martin SA, Myronyuk N, Rua M, Raffa RB (2011) Diabetes mellitus and Alzheimer’s disease: shared pathology and treatment. Br J Clin Pharmacol 71:365–376. https://doi.org/10.1111/J.1365-2125.2010.03830.X

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agatemor UM, Nwodo FOC, Ozah IR (2019) Inhibition of phospholipase A2 and prostaglandin synthase activities as possible mechanisms for the anti-inflammatory effect of cucumis sativus fruit homogenate. Acta Sci Pharm Sci 3:68–73. https://doi.org/10.31080/asps.2019.03.0314

Article  Google Scholar 

Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN (2009) Hyperglycemic crises in adult patients with diabetes. Diabetes Care 32:1335. https://doi.org/10.2337/DC09-9032

Article  CAS  PubMed  PubMed Central  Google Scholar 

Millogo-Kone H, Guissou I, Nacoulma O, Traore AS (2008) Comparative study of leaf and stem bark extracts of Parkia biglobosa against enterobacteria. Afr J Tradit Complement Altern Med 5:238. https://doi.org/10.4314/AJTCAM.V5I3.31279

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anaduaka EG, Ogugua VN, Egba SI, Apeh VO (2016) Investigation of some important phytochemical, nutritional properties and toxicological potentials of ethanol extracts of Newbouldia laevis leaf and stem. Afr J Biotech 12:5941–5949. https://doi.org/10.4314/ajb.v12i40

Article  Google Scholar 

Akerele JO, Ayinde BA, Ngiagah J (2011) Phytochemical and antibacterial evaluations of the stem bark of Newbouldia laevis against isolates from infected wounds and eyes. Trop J Pharm Res 10:211–218. https://doi.org/10.4314/tjpr.v10i2.66566

Article  Google Scholar 

Ejele A, Duru I, Ogukwe C, Iwu I (2012) Phytochemistry and antimicrobial potential of basic metabolites of Piper Umbellatum, Piper Guineense, Ocimum Gratissimium and Newbouldia Laevis extracts (Unpublished)

Ogunlana OE, Ogunlana OO (2008) In vitro assessment of antioxidant activity of Newbouldia laevis. J Med Plants Res. http://gateway.webofknowledge.com/gateway

Oloyede FA, Oloyede FM (2014) The antioxidant and food value of Chrysophyllum albidium G. Don. Sch J Agric Vet Sci 1(1):1–5

Google Scholar 

Oyeka EE, Asegbeloyin JN, Babahan I, Eboma B, Okpareke O, Lane J, Ibezim A, Bıyık HH, Törün B, Izuogu DC (2018) Synthesis, crystal structure, computational analysis and biological properties of 1-(4-chlorobenzoyl)-3-[2-(2-ethoxy)ethyl]-thiourea and its Ni(II) and Cu(II) complexes. J Mol Struct 1168:153–164. https://doi.org/10.1016/J.MOLSTRUC.2018.05.015

Article  CAS  Google Scholar 

Shen X, Chen W, Zheng Y, Lei X, Tang M, Wang H, Song F (2017) Chemical composition, antibacterial and antioxidant activities of hydrosols from different parts of Areca catechu L. and Cocos nucifera L. Ind Crops Prod 96:110–119. https://doi.org/10.1016/J.INDCROP.2016.11.053

Article  CAS  Google Scholar 

Jin H, Cia M, Li Y, Zhou J (1996) 1,10-phenanthroline-Fe2+ oxidative assay of hydroxyl radical produced by H2O2/Fe—ScienceOpen. Prog Biochem Biophys 23:553–555

CAS  Google Scholar 

Beauchamp C, Fridovich I (1997) Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 44:276–287. https://doi.org/10.1016/0003-2697(71)90370-8

Article  Google Scholar 

Sangameswaran BB, Balakrishnan B, Deshraj BR, Jayakar C (2009) In vitro antioxidant activity of roots of Thespesia lampas Dalz and Gibs—PubMed. Pak J Pharm Sci 22:368–372

CAS  PubMed  Google Scholar 

Oyaizu M (1986) Studies on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine. Jpn J Nutr Dietetics 44:307–315. https://doi.org/10.5264/EIYOGAKUZASHI.44.307

Article  CAS  Google Scholar 

Gulati V, Harding IH, Palombo EA (2012) Enzyme inhibitory and antioxidant activities of traditional medicinal plants: potential application in the management of hyperglycemia. BMC Complement Altern Med 12:1–9. https://doi.org/10.1186/1472-6882-12-77/TABLES/2

Article  Google Scholar 

Li Y, Wen S, Kota BP, Peng G, Li GQ, Yamahara J, Roufogalis BD (2005) Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. J Ethnopharmacol 99:239–244. https://doi.org/10.1016/J.JEP.2005.02.030

Article  PubMed  Google Scholar 

Trott O, Olson AJ (2009) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and Multithreading. J Comput Chem. https://doi.org/10.1002/jcc.21334

Article  Google Scholar 

O’Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR (2011) Open babel: an open chemical toolbox. J Cheminform. https://doi.org/10.1186/1758-2946-3-33

Article  PubMed  PubMed Central  Google Scholar 

Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004) UCSF Chimera—a visualization system for exploratory research and analysis. J Comput Chem 25:1605–1612. https://doi.org/10.1002/JCC.20084

Article  CAS  PubMed  Google Scholar 

Khan MTH, Orhan I, Şenol FS, Kartal M, Şener B, Dvorská M, Šmejkal K, Šlapetová T (2009) Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies. Chem Biol Interact 181:383–389. https://doi.org/10.1016/J.CBI.2009.06.024

Article  CAS  PubMed  Google Scholar 

Omeje KO, Ezema BO, Ozioko JN, Omeje HC, Ogidigo JO, Okeke OR, Nnorom CO (2020) Cholinesterases inhibition and antioxidant potentials of newbouldia laevis and ficus exasperata vahl leaf extract. Pharmacologyonline 1:77–91

CAS  Google Scholar 

Usman H, Osuji JC (2007) Phytochemical and in vitro antimicrobial assay of the leaf extract of Newbouldia laevis. Afr J Tradit Complement Altern Med 4:476. https://doi.org/10.4314/ajtcam.v4i4.31240

Article  CAS  PubMed  PubMed Central  Google Scholar 

Habu JB, Ibeh BO (2015) In vitro antioxidant capacity and free radical scavenging evaluation of active metabolite constituents of Newbouldia laevis ethanolic leaf extract. Biol Res. https://doi.org/10.1186/S40659-015-0007-X

Article  PubMed  PubMed Central  Google Scholar 

Costa LG, Garrick JM, Roquè PJ, Pellacani C (2016) Mechanisms of neuroprotection by quercetin: counteracting oxidative stress and more. Oxid Med Cell Longev. https://doi.org/10.1155/2016/2986796

Article  PubMed  PubMed Central  Google Scholar 

Bernatoniene J, Kopustinskiene DM (2018) The role of catechins in cellular responses to oxidative stress. Molecules (Basel, Switzerland) 23(4):965. https://doi.org/10.3390/MOLECULES23040965

Article  PubMed  Google Scholar 

Clarke KA, Dew TP, Watson REB, Farrar MD, Osman JE, Nicolaou A, Rhodes LE, Williamson G (2016) Green tea catechins and their metabolites in human skin before and after exposure to ultraviolet radiation. J Nutr Biochem 27:203. https://doi.org/10.1016/J.JNUTBIO.2015.09.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li W, Chen Z, Yan M, He P, Chen Z, Dai H (2016) The protective role of isorhamnetin on human brain microvascular endothelial cells from cytotoxicity induced by methylglyoxal and oxygen-glucose deprivation. J Neurochem 136:651–659. https://doi.org/10.1111/JNC.13436

Article  CAS  PubMed  Google Scholar 

Chen R, Qi QL, Wang MT, Li QY (2016) Therapeutic potential of naringin: an overview. Pharm Biol 54:3203–3210. https://doi.org/10.1080/13880209.2016.1216131

Article  CAS  PubMed  Google Scholar 

Kumar S, Kumar V, Rana M, Kumar D (2012) Enzymes inhibitors from plants: an alternate approach to treat diabetes. Pharmacogn Commun 2:18–33. https://doi.org/10.5530/PC.2012.2.4

Article  Google Scholar 

Mukherjee PK, Maiti K, Mukherjee K, Houghton PJ (2006) Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol 106:1–28. https://doi.org/10.1016/J.JEP.2006.03.021

Article  CAS  PubMed  Google Scholar 

Deng L, Qi Y, Liu Z, Xi Y, Xue W (2019) Effect of tannic acid on blood components and functions. Colloids Surf B Biointerfaces. https://doi.org/10.1016/J.COLSURFB.2019.110505

Article  PubMed  Google Scholar 

Patel K, Gadewar M, Tripathi R, Prasad SK, Patel DK (2012) A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid ‘“Harmine”,.’ Asian Pac J Trop Biomed 2:660. https://doi.org/10.1016/S2221-1691(12)60116-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuete V, Efferth T (2015) African flora has the potential to fight multidrug resistance of cancer. Biomed Res Int. https://doi.org/10.1155/2015/914813

Article  PubMed  PubMed Central  Google Scholar 

Srivastava J, Kumar S, Vankar PS (2012) Correlation of antioxidant activity and phytochemical profile in native plants. Nutr Food Sci 42:71–79. https://doi.org/10.1108/00346651211212024

Article  Google Scholar 

Panche AN, Diwan AD, Chandra SR (2016) Flavonoids: an overview. J Nutr Sci 5:1–15. https://doi.org/10.1017/JNS.2016.41

留言 (0)

沒有登入
gif