LaFerla FM (2002) Calcium dyshomeostasis and intracellular signalling in Alzheimer’s disease. Nat Rev Neurosci 3(11):862–872. https://doi.org/10.1038/nrn960

Article  CAS  PubMed  Google Scholar 

Marambaud P, Dreses-Werringloer U, Vingtdeux V (2009) Calcium signaling in neurodegeneration. Mol Neurodegener 4:20. https://doi.org/10.1186/1750-1326-4-20

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahaman YAR, Huang F, Kessete Afewerky H, Maibouge TMS, Ghose B, Wang X (2019) Involvement of calpain in the neuropathogenesis of Alzheimer’s disease. Med Res Rev 39(2):608–630. https://doi.org/10.1002/med.21534

Article  PubMed  Google Scholar 

Metwally E, Zhao G, Zhang YQ (2021) The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration. Trends Neurosci 44(9):741–752. https://doi.org/10.1016/j.tins.2021.07.003

Article  CAS  PubMed  Google Scholar 

Cascella R, Cecchi C (2021) Calcium dyshomeostasis in Alzheimer's disease pathogenesis. Int J Mol Sci 22(9). https://doi.org/10.3390/ijms22094914

Goll DE, Thompson VF, Li H, Wei W, Cong J (2003) The calpain system. Physiol Rev 83(3):731–801. https://doi.org/10.1152/physrev.00029.2002

Article  CAS  PubMed  Google Scholar 

Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH (1999) Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402(6762):615–622. https://doi.org/10.1038/45159

Article  CAS  PubMed  Google Scholar 

Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH (2003) Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40(3):471–483. https://doi.org/10.1016/s0896-6273(03)00627-5

Article  CAS  PubMed  Google Scholar 

Cheung ZH, Ip NY (2012) Cdk5: a multifaceted kinase in neurodegenerative diseases. Trends Cell Biol 22(3):169–175. https://doi.org/10.1016/j.tcb.2011.11.003

Article  CAS  PubMed  Google Scholar 

Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J et al (2003) Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron 38(4):555–565. https://doi.org/10.1016/s0896-6273(03)00259-9

Article  CAS  PubMed  Google Scholar 

Seo J, Kritskiy O, Watson LA, Barker SJ, Dey D, Raja WK, Lin YT, Ko T et al (2017) Inhibition of p25/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia. J Neurosci 37(41):9917–9924. https://doi.org/10.1523/jneurosci.0621-17.2017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu M, Huang Y, Song P, Huang Y, Huang W, Zhang HT, Hu Y (2019) AAV9-mediated Cdk5 inhibitory peptide reduces hyperphosphorylated tau and inflammation and ameliorates behavioral changes caused by overexpression of p25 in the brain. J Alzheimers Dis 70(2):573–585. https://doi.org/10.3233/jad-190099

Article  PubMed  Google Scholar 

Ghosh A, Greenberg ME (1995) Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 268(5208):239–247. https://doi.org/10.1126/science.7716515

Article  CAS  PubMed  Google Scholar 

Daverkausen-Fischer L, Pröls F (2022) Regulation of calcium homeostasis and flux between the endoplasmic reticulum and the cytosol. J Biol Chem 298(7):102061. https://doi.org/10.1016/j.jbc.2022.102061

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bagur R, Hajnóczky G (2017) Intracellular Ca(2+) sensing: its role in calcium homeostasis and signaling. Mol Cell 66(6):780–788. https://doi.org/10.1016/j.molcel.2017.05.028

Article  CAS  PubMed  PubMed Central  Google Scholar 

Verkhratsky A (2005) Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol Rev 85(1):201–279. https://doi.org/10.1152/physrev.00004.2004

Article  CAS  PubMed  Google Scholar 

Rajayer SR, Jacob A, Yang WL, Zhou M, Chaung W, Wang P (2013) Cold-inducible RNA-binding protein is an important mediator of alcohol-induced brain inflammation. PLoS One 8(11):e79430. https://doi.org/10.1371/journal.pone.0079430

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou M, Yang WL, Ji Y, Qiang X, Wang P (2014) Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia. Biochim Biophys Acta 1840(7):2253–2261. https://doi.org/10.1016/j.bbagen.2014.02.027

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aziz M, Brenner M, Wang P (2019) Extracellular CIRP (eCIRP) and inflammation. J Leukoc Biol 106(1):133–146. https://doi.org/10.1002/jlb.3mir1118-443r

Article  CAS  PubMed  Google Scholar 

Sharma A, Brenner M, Wang P (2020) Potential role of extracellular CIRP in alcohol-induced Alzheimer’s disease. Mol Neurobiol 57(12):5000–5010. https://doi.org/10.1007/s12035-020-02075-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma A, Brenner M, Jacob A, Marambaud P, Wang P (2021) Extracellular CIRP activates the IL-6Rα/STAT3/Cdk5 pathway in neurons. Mol Neurobiol 58(8):3628–3640. https://doi.org/10.1007/s12035-021-02368-z

Article  CAS  PubMed  Google Scholar 

Jacob A, Ma Y, Nasiri E, Ochani M, Carrion J, Peng S, Brenner M, Huerta PT et al (2019) Extracellular cold inducible RNA-binding protein mediates binge alcohol-induced brain hypoactivity and impaired cognition in mice. Mol Med 25(1):24. https://doi.org/10.1186/s10020-019-0092-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacob A, Wang P (2020) Alcohol intoxication and cognition: implications on mechanisms and therapeutic strategies. Front Neurosci 14:102. https://doi.org/10.3389/fnins.2020.00102

Article  PubMed  PubMed Central  Google Scholar 

Orellana DI, Quintanilla RA, Gonzalez-Billault C, Maccioni RB (2005) Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons. Neurotox Res 8(3–4):295–304. https://doi.org/10.1007/bf03033983

Article  CAS  PubMed  Google Scholar 

Quintanilla RA, Orellana DI, González-Billault C, Maccioni RB (2004) Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway. Exp Cell Res 295(1):245–257. https://doi.org/10.1016/j.yexcr.2004.01.002

Article  CAS  PubMed  Google Scholar 

Suzuki T, Imai J, Yamada T, Ishigaki Y, Kaneko K, Uno K, Hasegawa Y, Ishihara H et al (2011) Interleukin-6 enhances glucose-stimulated insulin secretion from pancreatic beta-cells: potential involvement of the PLC-IP3-dependent pathway. Diabetes 60(2):537–547. https://doi.org/10.2337/db10-0796

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qiang X, Yang WL, Wu R, Zhou M, Jacob A, Dong W, Kuncewitch M, Ji Y et al (2013) Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis. Nat Med 19(11):1489–1495. https://doi.org/10.1038/nm.3368

Article  CAS  PubMed  PubMed Central  Google Scholar 

Capiralla H, Vingtdeux V, Zhao H, Sankowski R, Al-Abed Y, Davies P, Marambaud P (2012) Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade. J Neurochem 120(3):461–472. https://doi.org/10.1111/j.1471-4159.2011.07594.x

Article  CAS  PubMed  Google Scholar 

Dreses-Werringloer U, Lambert JC, Vingtdeux V, Zhao H, Vais H, Siebert A, Jain A, Koppel J et al (2008) A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer’s disease risk. Cell 133(7):1149–1161. https://doi.org/10.1016/j.cell.2008.05.048

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH (2000) Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405(6784):360–364. https://doi.org/10.1038/35012636

Article  CAS  PubMed  Google Scholar 

Rao MV, McBrayer MK, Campbell J, Kumar A, Hashim A, Sershen H, Stavrides PH, Ohno M et al (2014) Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice. J Neurosci 34(28):9222–9234. https://doi.org/10.1523/jneurosci.1132-14.2014

Article  PubMed  PubMed Central  Google Scholar 

Sato K, Minegishi S, Takano J, Plattner F, Saito T, Asada A, Kawahara H, Iwata N et al (2011) Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25. J Neurochem 117(3):504–515. https://doi.org/10.1111/j.1471-4159.2011.07222.x

Article  CAS  PubMed  Google Scholar 

Baudry M, Bi X (2016) Calpain-1 and calpain-2: the Yin and Yang of synaptic plasticity and neurodegeneration. Trends Neurosci 39(4):235–245. https://doi.org/10.1016/j.tins.2016.01.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sorimachi H, Hata S, Ono Y (2011) Calpain chronicle–an enzyme family under multidisciplinary characterization. Proc Jpn Acad Ser B Phys Biol Sci 87(6):287–327. https://doi.org/10.2183/pjab.87.287

Article  CAS  PubMed