Horvitz HR, Herskowitz I (1992) Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question. Cell 68(2):237–255

Article  CAS  PubMed  Google Scholar 

Cheng H, Zheng Z, Cheng T (2020) New paradigms on hematopoietic stem cell differentiation. Protein Cell 11(1):34–44

Article  PubMed  Google Scholar 

Comazzetto S, Shen B, Morrison SJ (2021) Niches that regulate stem cells and hematopoiesis in adult bone marrow. Dev Cell 56(13):1848–1860

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghosh J, Koussa RE, Mohamad SF et al (2021) Cellular components of the hematopoietic niche and their regulation of hematopoietic stem cell function. Curr Opin Hematol 28(4):243–250

Article  CAS  PubMed  PubMed Central  Google Scholar 

Almotiri A, Alzahrani H, Menendez-Gonzalez JB et al (2021) Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia. J Clin Invest 131(1):e129115

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kruta M, Sunshine MJ, Chua BA et al (2021) Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging. Cell Stem Cell 28(11):1950-1965.e6

Article  CAS  PubMed  PubMed Central  Google Scholar 

García-Prat L, Kaufmann KB, Schneiter F et al (2021) TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate. Cell Stem Cell 28(10):1838-1850.e10

Article  PubMed  Google Scholar 

Schiroli G, Conti A, Ferrari S et al (2019) Precise gene editing preserves hematopoietic stem cell function following transient p53-mediated DNA damage response. Cell Stem Cell 24(4):551-565.e8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun X, Cao B, Naval-Sanchez M et al (2021) Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells. Nat Commun 12(1):2665

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang W, Zhang Y, Dettinger P et al (2021) Cytokine combinations for human blood stem cell expansion induce cell-type- and cytokine-specific signaling dynamics. Blood 138(10):847–857

Article  CAS  PubMed  Google Scholar 

Kruijf EFM, Fibbe WE, Pel M (2020) Cytokine-induced hematopoietic stem and progenitor cell mobilization: unraveling interactions between stem cells and their niche. Ann N Y Acad Sci 1466(1):24–38

Article  PubMed  Google Scholar 

Varshavsky A (2017) The ubiquitin system, autophagy, and regulated protein degradation. Annu Rev Biochem 86:123–128

Article  CAS  PubMed  Google Scholar 

Deng L, Meng T, Chen L et al (2020) The role of ubiquitination in tumorigenesis and targeted drug discovery. Signal Transduct Target Ther 5(1):11

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abdul Razak AR, Miller WH Jr, Uy GL et al (2020) A phase 1 study of the MDM2 antagonist RO6839921, a pegylated prodrug of idasanutlin, in patients with advanced solid tumors. Invest New Drugs 38(4):1156–1165

Article  CAS  PubMed  Google Scholar 

Abdul Razak AR, Bauer S, Suarez C et al (2022) Co-targeting of MDM2 and CDK4/6 with siremadlin and ribociclib for the treatment of patients with well-differentiated or dedifferentiated liposarcoma: results from a proof-of-concept, phase Ib study. Clin Cancer Res 28(6):1087–1097

Article  CAS  PubMed  Google Scholar 

Kud J, Wang W, Yuan Y et al (2019) Functional characterization of RING-type E3 ubiquitin ligases in vitro and in planta. J Vis Exp (154)

Bernassola F, Chillemi G, Melino G (2019) HECT-type E3 ubiquitin ligases in cancer. Trends Biochem Sci 44(12):1057–1075

Article  CAS  PubMed  Google Scholar 

Toma-Fukai S, Shimizu T (2021) Structural diversity of ubiquitin E3 ligase. Molecules 26(21):6682

Article  CAS  PubMed  PubMed Central  Google Scholar 

Das A, Middleton AJ, Padala P et al (2021) The structure and ubiquitin binding properties of TRAF RING heterodimers. J Mol Biol 433(8):166844

Article  CAS  PubMed  Google Scholar 

Buetow L, Huang DT (2016) Structural insights into the catalysis and regulation of E3 ubiquitin ligases. Nat Rev Mol Cell Biol 17(10):626–642

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng N, Wang P, Jeffrey PD, Pavletich NP (2000) Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell 102(4):533–539

Article  CAS  PubMed  Google Scholar 

Qi Y, Zhao X, Chen J et al (2019) In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6. Biosci Biotechnol Biochem 83(6):1011–1026

Article  CAS  PubMed  Google Scholar 

Sarkar S, Behera AP, Borar P et al (2019) Designing active RNF4 monomers by introducing a tryptophan: avidity towards E2∼Ub conjugates dictates the activity of ubiquitin RING E3 ligases. Biochem J 476(10):1465–1482

Article  CAS  PubMed  Google Scholar 

Keown JR, Yang J, Black MM, Coldstone DC (2020) The RING domain of TRIM69 promotes higher-order assembly. Acta Crystallogr D Struct Biol 76(Pt 10):954–961

Article  CAS  PubMed  Google Scholar 

Cardote TAF, Gadd MS, Ciulli A (2017) Crystal structure of the Cul2-Rbx1-EloBC-VHL ubiquitin ligase complex. Structure 25(6):901–911

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh S, Sivaraman J (2020) Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity. Biochem J 477(5):905–923

Article  CAS  PubMed  Google Scholar 

Rotin D, Kumar S (2009) Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol 10(6):398–409

Article  CAS  PubMed  Google Scholar 

Huang L, Kinnucan E, Wang G et al (1999) Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2–E3 enzyme cascade. Science 286(5443):1321–1326

Article  CAS  PubMed  Google Scholar 

Singh S, Ng J, Sivaraman J (2021) Exploring the “other” subfamily of HECT E3-ligases for therapeutic intervention. Pharmacol Ther 224:107809

Article  CAS  PubMed  Google Scholar 

Lijun L, Michowski W, Kolodziejczyk A et al (2019) The cell cycle in stem cell proliferation, pluripotency and differentiation. Nat Cell Biol 21(9):1060–1067

Article  Google Scholar 

Li L, Bhatia R (2011) Stem cell quiescence. Clin Cancer Res 17(15):4936–4941

Article  CAS  PubMed  PubMed Central  Google Scholar 

Velthoven CTJ, Rando TA et al (2019) Stem cell quiescence: dynamism, restraint, and cellular idling. Cell Stem Cell 24(2):213–225

Article  PubMed  PubMed Central  Google Scholar 

Urbán N, Cheung TH (2021) Stem cell quiescence: the challenging path to activation. Development 148(3):dev 165084

Trumpp A, Essers M, Wilson A (2010) Awakening dormant haematopoietic stem cells. Nat Rev Immunol 10(3):201–209

Article  CAS  PubMed  Google Scholar 

Vanegas NP, Vernot J (2017) Loss of quiescence and self-renewal capacity of hematopoietic stem cell in an in vitro leukemic niche. Exp Hematol Oncol 6:2

Article  PubMed  PubMed Central  Google Scholar 

Debili N, Wendling F, Cosman D et al (1995) The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. Blood 85(2):391–401

Article  CAS  PubMed  Google Scholar 

Lee JW, Kim HS, Yon S et al (2022) In vitro culture of hematopoietic stem cell niche using angiopoietin-1-coupled alginate hydrogel. Int J Biol Macromol 209(Pt B):1893–1899

Article  CAS  PubMed  Google Scholar 

Graaf CA, Kauppi M, Baldwin T et al (2010) Regulation of hematopoietic stem cells by their mature progeny. Proc Natl Acad Sci U S A 107(50):21689–21694

Article  PubMed  PubMed Central  Google Scholar