Targeting Myc-driven stress addiction in colorectal cancer

APCs

antigen presenting cells

ATF4

activating transcription factor 4

ATF6

activating transcription factor 6

BET

Bromodomain and extra-terminal domain

bZIP

basic Leucine Zipper domain

bHLH-LZ

basic-helix-loop-helix-leucine zipper

CD47

Cluster of Differentiation 47

CD24

Cluster of Differentiation 24

CDK

Cyclin-dependent kinase

CHOP

C/EBP Homologous Protein, encoded by DDIT3/GADD153

CIN

chromosome instability

CIMP

CpG island methylation phenotype

CTLs

Cytotoxic T lymphocytes

CTLA-4

Cytotoxic T lymphocyte-associated protein 4

cGAS

cyclic GMP-AMP synthase

DAMPs

Damage-associated molecular patterns

4E-BP1

eIF4E-binding protein 1

eIF2α

Eukaryotic translation initiation factor 2 alpha,encoded by EIF2S1

FDA

Food and Drug Administration

FOLFIRI

Folinic acid, 5-fluorouracil and irinotecan

FOLFOX

Folinic acid, 5-fluorouracil and oxaliplatin

GCN2

general control nonderepressible 2, encoded by EIF2AK4

GRP78

Glucose-Regulated Protein 78

GADD153

Growth arrest and DNA damage-inducible protein

GSK3

glycogen synthase kinase 3

HAT

histone acetyltransferases

HMGB1

high-mobility group box 1

HRI

Heme-Regulated Inhibitor, encoded by EIF2AK1

ICB

Immune checkpoint blockade

ICD

Immunogenic cell death

IRE1

inositol-requiring enzyme1

IRE1α

Inositol-requiring transmembrane kinase/endoribonuclease 1α

ISR

Integrated stress response

IKKα

Inhibitor of nuclear factor kappa-B kinase subunit alpha

IKKβ

Inhibitor of nuclear factor kappa-B kinase subunit beta

Max

Myc-associated protein X

Miz-1

Myc-interacting zinc finger protein 1

MHC

Major histocompatibility complex

MSI

Microsatellite instability

MDSCs

myeloid-derived suppressor cells

NKG2D

natural killer group 2D

NF-kB

nuclear factor kappa-B

PDL-1

Programmed Death Ligand 1

PERK

PKR-Like ER Kinase, encoded by EIF2AK3

PDO

patient derived organoids

PDX

patient derived xenografts

PROTACs

Proteolysis-targeting chimaeras

PKR

protein kinase R, encoded by EIF2AK2

PUMA

p53 upregulated modulator of apoptosis

PPI

protein-protein interaction

RNA Pol II

RNA polymerase II

RIDD

regulated IRE1α-dependent decay

STAT1

signal transducer and activator of transcription 1

SCD1

stearoyl-CoA desaturase 1

SPOP

Speckle-type POZ protein

STING1

Stimulator of interferon genes 1

TAD

amino-terminal transactivation domain

TRIB3

Tribbles Pseudokinase 3

TME

Tumor microenvironment

T-ALL

T-cell acute lymphoblastic leukemia

UPR

Unfolded protein response

USP7

Ubiquitin Specific Peptidase 7

XBP1

X-box-binding protein 1

YAP

Yes- Associated Protein 1

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