Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E, et al. Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nat Rev Drug Discov. 2018;17:660–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol Med. 2016;8:595–608.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82:239–59.

Article  CAS  PubMed  Google Scholar 

Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, et al. Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. JAMA Neurol. 2019;76:915.

Article  PubMed  PubMed Central  Google Scholar 

Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, et al. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nat Neurosci. 2019;22:57–64.

Article  CAS  PubMed  Google Scholar 

Busche MA, Hyman BT. Synergy between amyloid-β and tau in Alzheimer’s disease. Nat Neurosci. 2020;23:1183–93.

Article  CAS  PubMed  Google Scholar 

Palop JJ, Mucke L. Network abnormalities and interneuron dysfunction in Alzheimer disease. Nat Rev Neurosci. 2016;17:777–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Angulo SL, Orman R, Neymotin SA, Liu L, Buitrago L, Cepeda-Prado E, et al. Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit. Neurobiol Dis. 2017;108:261–76.

Article  CAS  PubMed  Google Scholar 

Menkes-Caspi N, Yamin HG, Kellner V, Spires-Jones TL, Cohen D, Stern EA. Pathological tau disrupts ongoing network activity. Neuron. 2015;85:959–66.

Article  CAS  PubMed  Google Scholar 

Marinković P, Blumenstock S, Goltstein PM, Korzhova V, Peters F, Knebl A, et al. In vivo imaging reveals reduced activity of neuronal circuits in a mouse tauopathy model. Brain. 2019;142:1051–62.

Article  PubMed  Google Scholar 

Fu H, Rodriguez GA, Herman M, Emrani S, Nahmani E, Barrett G, et al. Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease. Neuron. 2017;93:533-541.e5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, et al. Amyloid-β/Fyn–induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer’s disease. J Neurosci. 2011;31:700–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, et al. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer’s disease mouse model. Science. 2007;316:750–4.

Article  CAS  PubMed  Google Scholar 

Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer’s disease mouse models. Cell. 2010;142:387–97.

Article  CAS  PubMed  Google Scholar 

Thal DR, Rüb U, Orantes M, Braak H. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology. 2002;58:1791–800.

Article  PubMed  Google Scholar 

Zott B, Busche MA, Sperling RA, Konnerth A. What Happens with the Circuit in Alzheimer’s Disease in Mice and Humans? Annu Rev Neurosci. 2018;41:277–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Özcan GG, Lim S, Leighton PL, Allison WT, Rihel J. Sleep is bi-directionally modified by amyloid beta oligomers. Elife. 2020;9:e53995.

Article  PubMed  PubMed Central  Google Scholar 

Lew CH, Petersen C, Neylan TC, Grinberg LT. Tau-driven degeneration of sleep- and wake-regulating neurons in Alzheimer’s disease. Sleep Med Rev. 2021;60:101541.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ju Y-ES, Lucey BP, Holtzman DM. Sleep and Alzheimer disease pathology–a bidirectional relationship. Nat Rev Neurol. 2014;10:115–9.

Article  CAS  PubMed  Google Scholar 

Brown BM, Rainey-Smith SR, Villemagne VL, Weinborn M, Bucks RS, Sohrabi HR, et al. The Relationship between Sleep Quality and Brain Amyloid Burden. Sleep. 2016;39:1063–8.

Article  PubMed  PubMed Central  Google Scholar 

Minakawa EN, Wada K, Nagai Y. Sleep Disturbance as a Potential Modifiable Risk Factor for Alzheimer’s Disease. Int J Mol Sci. 2019;20:803.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bubu OM, Brannick M, Mortimer J, Umasabor-Bubu O, Sebastião YV, Wen Y, et al. Sleep, Cognitive impairment, and Alzheimer’s disease: A Systematic Review and Meta-Analysis. Sleep. 2017;40:zsw032.

Article  Google Scholar 

Bubu OM, Andrade AG, Umasabor-Bubu OQ, Hogan MM, Turner AD, de Leon MJ, et al. Obstructive sleep apnea, cognition and Alzheimer’s disease: A systematic review integrating three decades of multidisciplinary research. Sleep Med Rev. 2020;50:101250.

Article  PubMed  Google Scholar 

D’Rozario AL, Chapman JL, Phillips CL, Palmer JR, Hoyos CM, Mowszowski L, et al. Objective measurement of sleep in mild cognitive impairment: A systematic review and meta-analysis. Sleep Med Rev. 2020;52:101308.

Article  PubMed  Google Scholar 

Winer JR, Deters KD, Kennedy G, Jin M, Goldstein-Piekarski A, Poston KL, et al. Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging. JAMA Neurol. 2021;78:1187–96.

Article  PubMed  Google Scholar 

Ma D, Panda S, Lin JD. Temporal orchestration of circadian autophagy rhythm by C/EBPβ. EMBO J. 2011;30:4642–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342:373–7.

Article  CAS  PubMed  Google Scholar 

He Y, Cornelissen-Guillaume GG, He J, Kastin AJ, Harrison LM, Pan W. Circadian rhythm of autophagy proteins in hippocampus is blunted by sleep fragmentation. Chronobiol Int. 2016;33:553–60.

Article  CAS  PubMed  Google Scholar 

Holth JK, Fritschi SK, Wang C, Pedersen NP, Cirrito JR, Mahan TE, et al. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science. 2019;363:880–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodriguez GA, Barrett GM, Duff KE, Hussaini SA. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. PLoS Biol. 2020;18:e3000851.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ngo H-VV, Claassen J, Dresler M. Sleep: Slow Wave Activity Predicts Amyloid-β Accumulation. Curr Biol. 2020;30:R1371-3.

Article  CAS  PubMed  Google Scholar 

Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K, et al. Neuronal activity enhances tau propagation and tau pathology in vivo. Nat Neurosci. 2016;19:1085–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hafycz JM, Naidoo NN. Sleep, Aging, and Cellular Health: Aged-Related Changes in Sleep and Protein Homeostasis Converge in Neurodegenerative Diseases. Front Aging Neurosci. 2019;11:140.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, et al. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol. 2005;64:113–22.

Article  PubMed  Google Scholar 

Arnes M, Alaniz ME, Karam CS, Cho JD, Lopez G, Javitch JA, et al. Role of Tau Protein in Remodeling of Circadian Neuronal Circuits and Sleep. Front Aging Neurosci. 2019;11:320.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Forrest SL