GLOBAL SIGNATURES OF THE MICROBIOME AND METABOLOME DURING HOSPITALIZATION OF SEPTIC PATIENTS

∗Department of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, China

†NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai, China

‡Shanghai Key Laboratory of Lung Inflammation and Injury, Shanghai, China

§Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China

Received 26 Dec 2022; first review completed 10 Jan 2023; accepted in final form 8 Mar 2023

Address reprint requests to Zhenju Song, Department of Emergency Medicine, Zhongshan Hospital, Fudan University 180 Feng Lin Rd, Shanghai 200032, China. E-mail: [email protected]; Co-correspondence: Huajun Zheng, NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, 2140 Xietu Rd, Shanghai, China. E-mail: [email protected]; Co-correspondence: Sucheng Mu, Department of Emergency Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai 200032, China. E-mail: [email protected]; Co-correspondence: Jun Yin, Department of Emergency Medicine, Zhongshan Hospital, Fudan University 180 Feng Lin Rd, Shanghai 200032, China. E-mail: [email protected]

XL, SM, and JZ are the first coauthors.

This work was supported by the National Key Research and Development Program of China (2021YFC2501800), Shanghai Committee of Science and Technology (22Y11900100, 21MC1930400, 20Y11900100, 20DZ2261200), Clinical Research Plan of SHDC (SHDC2020CR4059), China Postdoctoral Science Foundation (2022M720783), and Shanghai Sailing Program (23YF1405000).

The authors report no conflict of interest.

This study was approved by the medical ethics committee of Zhongshan Hospital, Fudan University (no: B2014-082) and was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from all subjects or their legal representatives.

All authors approved the final version of the manuscript and agree to be accountable for all aspects of the work.

Availability of data and materials: The sequence data have been deposited in the National Omics Data Encyclopedia (NODE, https://www.biosino.org/node/) under accession number OEP003636.

Supplemental digital content is available for this article. Direct URL citation appears in the printed text and is provided in the HTML and PDF versions of this article on the journal’s Web site (www.shockjournal.com).

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