An S, Hu H, Li Y, Hu Y. Pyroptosis plays a role in osteoarthritis. Aging Dis. 2020;11:1146–57.

Article  PubMed  PubMed Central  Google Scholar 

Arden N, Nevitt MC. Osteoarthritis: epidemiology. Best Pract Res Clin Rheumatol. 2006;20:3–25.

Article  PubMed  Google Scholar 

Cao Y, Tang S, Nie X, Zhou Z, Ruan G, Han W, Zhu Z, Ding C. Decreased miR-214-3p activates NF-kappaB pathway and aggravates osteoarthritis progression. EBioMedicine. 2021;65:103283.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Lu Y, Pei C, Liang J, Ding P, Chen S, Hou SZ. Monotropein alleviates secondary liver injury in chronic colitis by regulating TLR4/NF-kappaB signaling and NLRP3 inflammasome. Eur J Pharmacol. 2020;883:173358.

Article  CAS  PubMed  Google Scholar 

Choi MC, Jo J, Park J, Kang HK, Park Y. NF-kappaB signaling pathways in osteoarthritic cartilage destruction. Cells-Basel. 2019. https://doi.org/10.3390/cells8070734.

Article  Google Scholar 

Glasson SS, Chambers MG, Van Den Berg WB, Little CB. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage. 2010;18(Suppl 3):S17–23.

Article  PubMed  Google Scholar 

Guo H, Callaway JB, Ting JP. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21:677–87.

Article  PubMed  PubMed Central  Google Scholar 

Guo Q, Chen X, Chen J, Zheng G, Xie C, Wu H, Miao Z, Lin Y, Wang X, Gao W, Zheng X, Pan Z, Zhou Y, Wu Y, Zhang X. STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-kappaB signaling pathway. Cell Death Dis. 2021;12:13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han D, Fang Y, Tan X, Jiang H, Gong X, Wang X, Hong W, Tu J, Wei W. The emerging role of fibroblast-like synoviocytes-mediated synovitis in osteoarthritis: an update. J Cell Mol Med. 2020;24:9518–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hou Y, Luan J, Huang T, Deng T, Li X, Xiao Z, Zhan J, Luo D, Hou Y, Xu L, Lin D. Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response. J Neuroinflammation. 2021;18:216.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu J, Zhou J, Wu J, Chen Q, Du W, Fu F, Yu H, Yao S, Jin H, Tong P, Chen D, Wu C, Ruan H. Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-kappaB activity and pyroptosis in chondrocytes. J Ethnopharmacol. 2020;247: 112261.

Article  CAS  PubMed  Google Scholar 

Hunter DJ, March L, Chew M. Osteoarthritis in 2020 and beyond: a lancet commission. Lancet. 2020;396:1711–2.

Article  PubMed  Google Scholar 

Hwang HS, Kim HA. Chondrocyte apoptosis in the pathogenesis of osteoarthritis. Int J Mol Sci. 2015;16:26035–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jia S, Yang Y, Bai Y, Wei Y, Zhang H, Tian Y, Liu J, Bai L. Mechanical stimulation protects against chondrocyte pyroptosis through irisin-induced suppression of PI3K/Akt/NF-kappaB Signal pathway in osteoarthritis. Front Cell Dev Biol. 2022;10:797855.

Article  PubMed  PubMed Central  Google Scholar 

Jiang F, Xu XR, Li WM, Xia K, Wang LF, Yang XC. Monotropein alleviates H2O2induced inflammation, oxidative stress and apoptosis via NFkappaB/AP1 signaling. MOL MED REP. 2020;22:4828–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jimi, E. , Fei, H. , Nakatomi, C. , 2019. NF-kappaB Signaling regulates physiological and pathological chondrogenesis. INT J MOL SCI 20.

Jones IA, Togashi R, Wilson ML, Heckmann N, Vangsness CJ. Intra-articular treatment options for knee osteoarthritis. NAT REV RHEUMATOL. 2019;15:77–90.

Article  PubMed  PubMed Central  Google Scholar 

Katz JN, Arant KR, Loeser RF. Diagnosis and treatment of hip and knee osteoarthritis: a review. JAMA. 2021;325:568–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kloppenburg M, Berenbaum F. Osteoarthritis year in review 2019: epidemiology and therapy. Osteoarthritis Cartilage. 2020;28:242–8.

Article  CAS  PubMed  Google Scholar 

Kovacs SB, Miao EA. Gasdermins: effectors of pyroptosis. Trends Cell Biol. 2017;27:673–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1: a1651.

Article  Google Scholar 

Li Z, Huang Z, Zhang H, Lu J, Tian Y, Wei Y, Yang Y, Bai L. P2X7 receptor induces pyroptotic inflammation and cartilage degradation in osteoarthritis via NF-kappaB/NLRP3 crosstalk. Oxid Med Cell Longev. 2021;2021:8868361.

PubMed  PubMed Central  Google Scholar 

Luo D, Li X, Hou Y, Hou Y, Luan J, Weng J, Zhan J, Lin D. Sodium tanshinone IIA sulfonate promotes spinal cord injury repair by inhibiting blood spinal cord barrier disruption in vitro and in vivo. Drug Dev Res. 2022;83:669–79.

CAS  PubMed  Google Scholar 

McAllister MJ, Chemaly M, Eakin AJ, Gibson DS, McGilligan VE. NLRP3 as a potentially novel biomarker for the management of osteoarthritis. Osteoarthritis Cartilage. 2018;26:612–9.

Article  CAS  PubMed  Google Scholar 

Mehana EE, Khafaga AF, El-Blehi SS. The role of matrix metalloproteinases in osteoarthritis pathogenesis: an updated review. Life Sci. 2019;234: 116786.

Article  CAS  PubMed  Google Scholar 

Poole AR, Kobayashi M, Yasuda T, Laverty S, Mwale F, Kojima T, Sakai T, Wahl C, El-Maadawy S, Webb G, Tchetina E, Wu W. Type II collagen degradation and its regulation in articular cartilage in osteoarthritis. Ann Rheum Dis. 2002;61(Suppl 2):i78–81.

Article  Google Scholar 

Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A, Arden NK. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 2014;73:1659–64.

Article  PubMed  Google Scholar 

Qvist P, Bay-Jensen AC, Christiansen C, Dam EB, Pastoureau P, Karsdal MA. The disease modifying osteoarthritis drug (DMOAD): is it in the horizon? Pharmacol Res. 2008;58:1–7.

Article  CAS  PubMed  Google Scholar 

Rahmati M, Nalesso G, Mobasheri A, Mozafari M. Aging and osteoarthritis: central role of the extracellular matrix. Ageing Res Rev. 2017;40:20–30.

Article  CAS  PubMed  Google Scholar 

Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42:245–54.

Article  CAS  PubMed  Google Scholar 

Shi Y, Liu XY, Jiang YP, Zhang JB, Zhang QY, Wang NN, Xin HL. Monotropein attenuates oxidative stress via Akt/mTOR-mediated autophagy in osteoblast cells. Biomed Pharmacother. 2020;121:109566.

Article  CAS  PubMed  Google Scholar 

Wang BW, Jiang Y, Yao ZL, Chen PS, Yu B, Wang SN. Aucubin protects chondrocytes against il-1beta-induced apoptosis in vitro and inhibits osteoarthritis in mice model. Drug Des Devel Ther. 2019;13:3529–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang C, Mao C, Lou Y, Xu J, Wang Q, Zhang Z, Tang Q, Zhang X, Xu H, Feng Y. Monotropein promotes angiogenesis and inhibits oxidative stress-induced autophagy in endothelial progenitor cells to accelerate wound healing. J Cell Mol Med. 2018;22:1583–600.

Article  CAS  PubMed  Google Scholar 

Wang F, Wu L, Li L, Chen S. Monotropein exerts protective effects against IL-1beta-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Int Immunopharmacol. 2014;23:575–80.

Article  CAS  PubMed  Google Scholar 

Wang Q, Ou Y, Hu G, Wen C, Yue S, Chen C, Xu L, Xie J, Dai H, Xiao H, Zhang Y, Qi R. Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-kappaB pathway in mice. Br J Pharmacol. 2020;177:1806–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Whittaker JL, Truong LK, Dhiman K, Beck C. Osteoarthritis year in review 2020: rehabilitation and outcomes. Osteoarthritis Cartilage. 2021;29:190–207.

Article  CAS  PubMed  Google Scholar 

Won Y, Shin Y, Chun CH, Cho Y, Ha CW, Kim JH, Chun JS. Pleiotropic roles of metallothioneins as regulators of chondrocyte apoptosis and catabolic and anabolic pathways during osteoarthritis pathogenesis. Ann Rheum Dis. 2016;75:2045–52.

Article  CAS  P