Sung H, Ferlay J, Siegel RL, Laversanne M et al (2021) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660

Jiang D, Zhang L, Liu W, Ding Y et al (2021) Trends in cancer mortality in China from 2004 to 2018: a nationwide longitudinal study. Cancer Commun (Lond) 41(10):1024–1036. https://doi.org/10.1002/cac2.12195

Wei T, Zhang X, Bagante F, Ratti F et al (2021) Early versus late recurrence of hepatocellular carcinoma after surgical resection based on post-recurrence survival: an international multi-institutional analysis. J Gastrointest Surg 25(1):125–133. https://doi.org/10.1007/s11605-020-04553-2

Yang P, Qiu J, Li J, Wu D et al (2016) Nomograms for pre- and postoperative prediction of long-term survival for patients who underwent hepatectomy for multiple hepatocellular carcinomas. Ann Surg 263(4):778–786. https://doi.org/10.1097/SLA.0000000000001339

Baum M, Demicheli R, Hrushesky W, Retsky M (2005) Does surgery unfavourably perturb the “natural history” of early breast cancer by accelerating the appearance of distant metastases? Eur J Cancer (1990) 41(4):508–515. https://doi.org/10.1016/j.ejca.2004.09.031

Looney M, Doran P, Buggy DJ (2010) Effect of anesthetic technique on serum vascular endothelial growth factor C and transforming growth factor β in women undergoing anesthesia and surgery for breast cancer. Anesthesiology 113(5):1118–1125. https://doi.org/10.1097/ALN.0b013e3181f79a69

Kim R (2018) Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence. J Transl Med 16(1):8. https://doi.org/10.1186/s12967-018-1389-7

Wall TP, Buggy DJ (2021) Perioperative intravenous lidocaine and metastatic cancer recurrence - a narrative review. Front Oncol 11:688896. https://doi.org/10.3389/fonc.2021.688896

Jurj A, Tomuleasa C, Tat TT, Neagoe IB, Vesa SV, Ionescu DC (2020) Antiproliferative and apoptotic effects of lidocaine on human hepatocarcinoma cells. A preliminary study. J Gastrointestin Liver Dis 26(1):45–50. https://doi.org/10.15403/jgld.2014.1121.261.juj

Xing W, Chen D, Pan J, Chen Y et al (2017) Lidocaine induces apoptosis and suppresses tumor growth in human hepatocellular carcinoma cells in vitro and in a xenograft model in vivo. Anesthesiology 126(5):868–881. https://doi.org/10.1097/ALN.0000000000001528

Zhang H, Yang L, Zhu X, Zhu M et al (2020) Association between intraoperative intravenous lidocaine infusion and survival in patients undergoing pancreatectomy for pancreatic cancer: a retrospective study. Br J Anaesth 125(2):141–148. https://doi.org/10.1016/j.bja.2020.03.034

Zhang H, Gu J, Qu M, Sun Z et al (2022) Effects of intravenous infusion of lidocaine on short-term outcomes and survival in patients undergoing surgery for ovarian cancer: a retrospective propensity score matching study. Front Oncol 11:689832. https://doi.org/10.3389/fonc.2021.689832

Orlando R, Piccoli P, De Martin S, Padrini R, Floreani M, Palatini P (2004) Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function. Clin Pharmacol Ther 75(1):80–88. https://doi.org/10.1016/j.clpt.2003.09.007

Orlando R, Piccoli P, De Martin S, Padrini R, Palatini P (2003) Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function. Br J Clin Pharmacol 55(1):86–93. https://doi.org/10.1046/j.1365-2125.2003.01718.x

Strong JM, Mayfield DE, Atkinson AJ, Burris BC, Raymon F, Webster LJ (1975) Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidide. Clin Pharmacol Ther 17(2):184–194. https://doi.org/10.1002/cpt1975172184

Strong JM, Parker M, Atkinson AJ (1973) Identification of glycinexylidide in patients treated with intravenous lidocaine. Clin Pharmacol Ther 14(1):67–72. https://doi.org/10.1002/cpt197314167

Narang PK, Crouthamel WG, Carliner NH, Fisher ML (1978) Lidocaine and its active metabolites. Clin Pharmacol Ther 24(6):654

Article  CAS  PubMed  Google Scholar 

Thomson PD, Melmon KL, Richardson JA, Cohn K et al (1973) Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans. Ann Intern Med 78(4):499

Article  CAS  PubMed  Google Scholar 

Inoue Y, Suzuki Y, Fujii K, Kawaguchi N et al (2018) Laparoscopic hepatic resection using extracorporeal Pringle maneuver. J Laparoendosc Adv Surg Tech 28(4):452–458. https://doi.org/10.1089/lap.2017.0196

Sanjay P, Ong I, Bartlett A, Powell JJ, Wigmore SJ (2013) Meta-analysis of intermittent Pringle manoeuvre versus no Pringle manoeuvre in elective liver surgery. Anz J Surg 83(10):n/a-n/a. https://doi.org/10.1111/ans.12312

Halkin H, Meffin P, Melmon KL, Rowland M (1975) Influence of congestive heart failure on blood levels of lidocaine and its active monodeethylated metabolite. Clin Pharmacol Ther 17(6):669–676. https://doi.org/10.1002/cpt1975176669

Xu Y, Ye M, Hong Y, Kang Y et al (2021) Efficacy of perioperative continuous intravenous lidocaine infusion for 72 hours on postoperative pain and recovery in patients undergoing hepatectomy: study protocol for a prospective randomized controlled trial. J Pain Res 14:3665–3674. https://doi.org/10.2147/JPR.S341550

Jin Y, He C, Di X, Fu L et al (2022) Simultaneous determination of lidocaine and its active metabolites in plasma by UPLC-MS/MS and application to a clinical pharmacokinetic study in liver cancer patients with laparoscopic hepatectomy. J Chromatogr B Analyt Technol Biomed Life Sci 1207:123362. https://doi.org/10.1016/j.jchromb.2022.123362

Foo I, Macfarlane AJR, Srivastava D, Bhaskar A et al (2021) The use of intravenous lidocaine for postoperative pain and recovery: international consensus statement on efficacy and safety. Anaesthesia 76(2):238–250. https://doi.org/10.1111/anae.15270

Berkenstadt H, Segal E, Mayan H, Almog S et al (1999) The pharmacokinetics of morphine and lidocaine in critically ill patients. Intensive Care Med 25(1):110–112. https://doi.org/10.1007/s001340050796

Berkenstadt H, Mayan H, Segal E, Rotenberg M et al (1999) The pharmacokinetics of morphine and lidocaine in nine severe trauma patients. J Clin Anesth 11(8):630–634. https://doi.org/10.1016/s0952-8180(99)00115-4

Huet P, Villeneuve J (1983) Determinants of drug disposition in patients with cirrhosis. Hepatology 3(6):913–918. https://doi.org/10.1002/hep.1840030604

De Martin S, Orlando R, Bertoli M, Pegoraro P, Palatini P (2006) Differential effect of chronic renal failure on the pharmacokinetics of lidocaine in patients receiving and not receiving hemodialysis. Clin Pharmacol Ther 80(6):597–606. https://doi.org/10.1016/j.clpt.2006.08.020

De Oliveira K, Eipe N (2020) Intravenous lidocaine for acute pain: a single-institution retrospective study. Drugs Real World Outcomes 7(3):205–212. https://doi.org/10.1007/s40801-020-00205-8

Marret E, Rolin M, Beaussier M, Bonnet F (2008) Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery. Br J Surg 95(11):1331–1338. https://doi.org/10.1002/bjs.6375

Herroeder S, Pecher S, Schoenherr ME, Kaulitz G et al (2007) Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial. Ann Surg 246(2):192–200. https://doi.org/10.1097/SLA.0b013e31805dac11

Thomson AH, Elliott HL, Kelman AW, Meredith PA, Whiting B (1987) The pharmacokinetics and pharmacodynamics of lignocaine and MEGX in healthy subjects. J Pharmacokinet Biopharm 15(2):101–115. https://doi.org/10.1007/BF01062338

Meagher D (2009) Motor subtypes of delirium: past, present and future. Int Rev Psychiatry 21(1):59–73. https://doi.org/10.1080/09540260802675460

Rengel KF, Pandharipande PP, Hughes CG (2018) Postoperative delirium. La Presse Médicale 47(4):e53-e64. https://doi.org/10.1016/j.lpm.2018.03.012

Evered L, Silbert B, Knopman DS, Scott DA et al (2018) Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018. Br J Anaesth 121(5):1005–1012. https://doi.org/10.1016/j.bja.2017.11.087

Milstein A, Pollack A, Kleinman G, Barak Y (2002) Confusion/delirium following cataract surgery: an incidence study of 1-year duration. Int Psychogeriatr 14(3):301–306. https://doi.org/10.1017/S1041610202008499

Pandharipande P, Shintani A, Peterson J, Pun BT et al (2006) Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 104(1):21–26. https://doi.org/10.1097/00000542-200601000-00005

Hirsch J, Depalma G, Tsai TT, Sands LP, Leung JM (2015) Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after non-cardiac surgery. Br J Anaesth 115(3):418–426. https://doi.org/10.1093/bja/aeu458