Lactate acidosis and hypoglycaemia in twin anaemia polycythemia sequence donors

Twin anaemia polycythemia sequence (TAPS) is a monochorionic twin condition that occurs due to imbalanced chronic feto-fetal transfusion through minuscule vascular placental anastomoses, leading to anaemia in the donor twin and polycythemia in the recipient twin. Donors are significantly more at risk of developing severe long-term neurodevelopmental impairment (NDI) (18%) than recipients (3%).1 The cause for this difference in outcome is not well understood. Previous studies showed that neonatal lactate acidosis and hypoglycaemia are associated with long-term impairment.2 3 To date, the prevalence of these metabolic conditions has not been studied in TAPS. This study was set up to investigate the prevalence of lactate acidosis and hypoglycaemia in TAPS donors and recipients, to explore potential hypotheses for the difference …

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