Abdelaziz A, Spahn-Langguth H, Schramm KW, Tetko IV (2016) Consensus modeling for HTS assays using in silico descriptors calculates the best balanced accuracy in Tox21 challenge. Front Environm Sci. https://doi.org/10.3389/fenvs.2016.00002

Article  Google Scholar 

Arp HPH, Hale SE (2022) Assessing the persistence and mobility of organic substances to protect freshwater resources. ACS Environm Au. https://doi.org/10.1021/acsenvironau.2c00024

Article  Google Scholar 

Auerbach S, Filer D, Reif D, Walker V, Holloway Alison C, Schlezinger J, Srinivasan S, Svoboda D, Judson R, Bucher John R, Thayer Kristina A (2016) Prioritizing environmental chemicals for obesity and diabetes outcomes research: a screening approach using ToxCast™ High-throughput data. Environ Health Perspect 124(8):1141–1154. https://doi.org/10.1289/ehp.1510456

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aven T (2011) On Some recent definitions and analysis frameworks for risk, vulnerability, and resilience. Risk Anal 31(4):515–522. https://doi.org/10.1111/j.1539-6924.2010.01528.x

Article  PubMed  Google Scholar 

Ball N, Bars R, Botham PA, Cuciureanu A, Cronin MTD, Doe JE, Dudzina T, Gant TW, Leist M, van Ravenzwaay B (2022) A framework for chemical safety assessment incorporating new approach methodologies within REACH. Arch Toxicol 96(3):743–766. https://doi.org/10.1007/s00204-021-03215-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Behl M, Ryan K, Hsieh JH, Parham F, Shapiro AJ, Collins BJ, Sipes NS, Birnbaum LS, Bucher JR, Foster PMD, Walker NJ, Paules RS, Tice RR (2019) Screening for developmental neurotoxicity at the national toxicology program: the future is here. Toxicol Sci 167(1):6–14. https://doi.org/10.1093/toxsci/kfy278

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bell SM, Chang XQ, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes NS, Sprankle CS, Strickland J, Troutman J, Wetmore BA, Kleinstreuer NC (2018) In vitro to in vivo extrapolation for high throughput prioritization and decision making. Toxicol in Vitro 47:213–227. https://doi.org/10.1016/j.tiv.2017.11.016

Article  CAS  PubMed  Google Scholar 

Bennett D, Bellinger David C, Birnbaum Linda S, Null N, Bradman A, Chen A, Cory-Slechta Deborah A, Engel Stephanie M, Fallin MD, Halladay A, Hauser R, Hertz-Picciotto I, Kwiatkowski Carol F, Lanphear Bruce P, Marquez E, Marty M, McPartland J, Newschaffer Craig J, Payne-Sturges D, Patisaul Heather B, Perera Frederica P, Ritz B, Sass J, Schantz Susan L, Webster Thomas F, Whyatt Robin M, Woodruff Tracey J, Zoeller RT, Anderko L, Campbell C, Conry Jeanne A, DeNicola N, Gould Robert M, Hirtz D, Huffling K, Landrigan Philip J, Lavin A, Miller M, Mitchell Mark A, Rubin L, Schettler T, Tran Ho L, Acosta A, Brody C, Miller E, Miller P, Swanson M, Witherspoon Nsedu O (2016) Project TENDR: targeting environmental neuro-developmental risks The TENDR consensus statement. Environm Health Perspect 124(7):A118–A122. https://doi.org/10.1289/EHP358

Article  Google Scholar 

Betts KS (2013) Tox21 to date steps toward modernizing human hazard characterization. Environ Health Perspect 121(7):A228–A228. https://doi.org/10.1289/ehp.121-a228

Article  PubMed  PubMed Central  Google Scholar 

Birnbaum L, Burke T, Jones J (2016) Informing 21st-century risk assessments with 21st-century science. Environ Health Perspect 124(4):A60-63. https://doi.org/10.1289/ehp.1511135

Article  PubMed  PubMed Central  Google Scholar 

Blaauboer BJ (2015) The long and winding road of progress in the use of in vitro data for risk assessment purposes: From “carnation test” to integrated testing strategies. Toxicology 332:4–7. https://doi.org/10.1016/j.tox.2014.04.004

Article  CAS  PubMed  Google Scholar 

Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer A-K, Hübenthal U, Kebel HE, Kilic S, Klose J, Pahl M, Stürzl L-C, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E (2023) Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals. Chemosphere 311:137035. https://doi.org/10.1016/j.chemosphere.2022.137035

Article  CAS  Google Scholar 

Bopp SK, Barouki R, Brack W, Dalla Costa S, Dorne J, Drakvik PE, Faust M, Karjalainen TK, Kephalopoulos S, van Klaveren J, Kolossa-Gehring M, Kortenkamp A, Lebret E, Lettieri T, Norager S, Ruegg J, Tarazona JV, Trier X, van de Water B, van Gils J, Bergman A (2018) Current EU research activities on combined exposure to multiple chemicals. Environm Int 120:544–562. https://doi.org/10.1016/j.envint.2018.07.037

Article  CAS  Google Scholar 

Bopp SK, Kienzler A, Richarz AN, van der Linden SC, Paini A, Parissis N, Worth AP (2019) Regulatory assessment and risk management of chemical mixtures: challenges and ways forward. Crit Rev Toxicol 49(2):174–189. https://doi.org/10.1080/10408444.2019.1579169

Article  PubMed  Google Scholar 

Boxall ABA, Sinclair CJ, Fenner K, Kolpin D, Maud SJ (2004) When synthetic chemicals degrade in the environment. Environ Sci Technol 38(19):368A-375A

Article  CAS  PubMed  Google Scholar 

Brendel S, Fetter É, Staude C, Vierke L, Biegel-Engler A (2018) Short-chain perfluoroalkyl acids: environmental concerns and a regulatory strategy under REACH. Environ Sci Eur 30(1):9. https://doi.org/10.1186/s12302-018-0134-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brillet F, Maul A, Durand M-J, Thouand G (2016) From laboratory to environmental conditions: a new approach for chemical’s biodegradability assessment. Environ Sci Pollut Res 23(18):18684–18693. https://doi.org/10.1007/s11356-016-7062-x

Article  CAS  Google Scholar 

Burden N, Sewell F, Andersen ME, Boobis A, Chipman JK, Cronin MTD, Hutchinson TH, Kimber I, Whelan M (2015) Adverse Outcome Pathways can drive non-animal approaches for safety assessment. J Appl Toxicol 35(9):971–975. https://doi.org/10.1002/jat.3165

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carusi A, Davies M, De Grandis G, Escher B, Hodges G, Leung KMY, Whelan M, Willett C, Ankley G (2018) Harvesting the Promise of AOPs: an assessment and recommendations. Sci Total Environ 628–629:1542–1556

Article  PubMed  PubMed Central  Google Scholar 

Castro M, Sobek A, Yuan B, Breitholtz M (2019) Bioaccumulation potential of CPs in aquatic organisms: uptake and depuration in daphnia magna. Environ Sci Technol 53(16):9533–9541. https://doi.org/10.1021/acs.est.9b01751

Article  CAS  PubMed  Google Scholar 

Catron TR, Keely SP, Brinkman NE, Zurlinden TJ, Wood CE, Wright JR, Phelps D, Wheaton E, Kvasnicka A, Gaballah S, Lamendella R, Tal T (2019) Host developmental toxicity of BPA and BPA alternatives Is inversely RELATED to microbiota disruption in zebrafish. Toxicol Sci 167(2):468–483. https://doi.org/10.1093/toxsci/kfy261

Article  CAS  PubMed  Google Scholar 

Celebi Sozener Z, Ozdel Ozturk B, Cerci P, Turk M, Gorgulu Akin B, Akdis M, Altiner S, Ozbey U, Ogulur I, Mitamura Y, Yilmaz I, Nadeau K, Ozdemir C, Mungan D, Akdis CA (2022) Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease. Allergy 77(5):1418–1449. https://doi.org/10.1111/all.15240

Article  PubMed  Google Scholar 

Collins F, Gray GN, Bucher JR (2008) Transforming environmental health protection. Science 319:906–907

Article  CAS  PubMed  PubMed Central  Google Scholar 

European Commission (2013) European Commission, Directorate-General for Health and Consumers, Toxicity and assessment of chemical mixtures, European Commission, Doi: https://doi.org/10.2772/21444.

European Commission (2020) Communication from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions (COM (2020) 667 final). Chemicals Strategy for Sustainability towards a Toxic-free Environment. European Communities

den Braver-Sewradj SP, van Spronsen R, Hessel EVS (2020) Substitution of bisphenol A: a review of the carcinogenicity, reproductive toxicity, and endocrine disruption potential of alternative substances. Crit Rev Toxicol 50(2):128–147. https://doi.org/10.1080/10408444.2019.1701986

Article  CAS  Google Scholar 

Drakvik E, Altenburger R, Aoki Y, Backhaus T, Bahadori T, Barouki R, Brack W, Cronin MTD, Demeneix B, Bennekou SH, van Klaveren J, Kneuer C, Kolossa-Gehring M, Lebret E, Posthuma L, Reiber L, Rider C, Ruegg J, Testa G, van der Burg B, van der Voet H, Warhurst AM, van de Water B, Yamazaki K, Oberg M, Bergman A (2020) Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment. Environ Int 134:105267. https://doi.org/10.1016/j.envint.2019.105267

Article  CAS  PubMed  Google Scholar 

ECHA (2017a) Guidance on Information Requirements and Chemical Safety Assessment Chapter R.11: PBT/vPvB assessment. Version 3.0.European Chemicals Agency,

ECHA (2017b) Guidance on Information Requirements and Chemical Safety Assessment Part C: PBT/vPvB assessment. Version 3.0.European Chemicals Agency

ECHA (2017c) Read-Across Assessment Framework (RAAF)—considerations on multi-constituent substances and UVCBs. 102823/794394:European Chemicals Agency. Doi:https://doi.org/10.2823/794394

enHealth (2004) Environmental health risk assessment. Guidelines for assessing human health risks from environmental hazards. Department of Health and Aging and enHealth Council, Canberra, Australia

U.S. EPA (1976) Toxic substances control act. U.S. Environmental Protection Agency. Washington DC, USA

U.S. EPA (2021) New Approach Methods Work Plan (v2). U.S. Environmental Protection Agency, Washington, DC. EPA/600/X-21/209.

U.S. EPA (2022) EPA New Approach Methods Work Plan: Reducing Use of Vertebrate Animals in Chemical Testing. Accessed 30 July 2022

EP&EC (2006) Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. European Parliament and European Council, Official Journal of the European Communities

EP&EC (2008) Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. Official Journal of the European Communities L 353/1 31.12.2008

EP&EC (2020) Regulation (EU) 2020/741 of the European parliament and of the Council of 25 May 2020 on minimum requirements for water reuse. European Parliament and European Council, Official Journal of the European Communities

Escher BI, Fenner K (2011) Recent advances in the environmental risk assessment of transformation products. Environ Sci Technol 45(9):3835–3847. https://doi.org/10.1021/es1030799

Article  CAS  PubMed  Google Scholar 

Escher BI, Glauch L, Konig M, Mayer P, Schlichting R (2019) Baseline toxicity and volatility cutoff in reporter gene assays used for high-throughput screening. Chem Res Toxicol 32(8):1646–1655. https://doi.org/10.1021/acs.chemrestox.9b00182

Article  CAS  PubMed  Google Scholar 

Escher BI, Stapleton HM, Schymanski EL (2020) Tracking complex mixtures of chemicals in our changing environment. Sci 397:388–392. https://doi.org/10.1126/science.aay6636

Article  CAS  Google Scholar 

Escher B, Neale P, Leusch F (2021) Bioanalytical tools in water quality assessment, second edition, www.iwapublishing.com/books/9781789061970/bioanalytical-tools-water-quality-assessment-2nd-edition. IWA Publishing, London, UK

Ezendam J, Braakhuis HM, Vandebriel RJ (2016) State of the art in non-animal approaches for skin sensitization testing: from individual test methods towards testing strategies. Arch Toxicol 90(12):2861–2883. https://doi.org/10.1007/s00204-016-1842-4

Article  CAS  PubMed  Google Scholar 

Fang WD, Peng Y, Yan L, Xia P, Zhang XW (2020) A tiered approach for screening and assessment of environmental mixtures by omics and in vitro assays. Environ Sci Technol 54(12):7430–7439. https://doi.org/10.1021/acs.est.0c00662

Article  CAS  PubMed  Google Scholar