Innovation in Targeted Intra-articular Therapies for Osteoarthritis

Katz JN, Arant KR, Loeser RF. Diagnosis and treatment of hip and knee osteoarthritis: a review. JAMA. 2021;325(6):568–78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

O’Neill TW, McCabe PS, McBeth J. Update on the epidemiology, risk factors and disease outcomes of osteoarthritis. Best Pract Res Clin Rheumatol. 2018;32(2):312–26.

Article  PubMed  Google Scholar 

OARSI White Paper—Osteoarthritis as a serious disease. 2016. https://www.oarsi.org/sites/default/files/docs/2016/oarsi_white_paper_oa-serious-disease.pdf. Accessed 26 Feb 2023.

Jin Z, Wang D, Zhang H, Liang J, Feng X, Zhao J, et al. Incidence trend of five common musculoskeletal disorders from 1990 to 2017 at the global, regional and national level: results from the global burden of disease study 2017. Ann Rheum Dis. 2020;79(8):1014–22.

Article  PubMed  Google Scholar 

Osteoarthritis: Structural Endpoints for the Development of Drugs. U.S. Food and Drug Administration; 2019.

Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162(1):46–54.

Article  PubMed  Google Scholar 

Pereira TV, Jüni P, Saadat P, Xing D, Yao L, Bobos P, et al. Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis. BMJ. 2022;6(378): e069722.

Article  Google Scholar 

Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthr Cartil. 2013;21(1):16–21.

Article  CAS  Google Scholar 

Mathiessen A, Conaghan PG. Synovitis in osteoarthritis: current understanding with therapeutic implications. Arthritis Res Ther. 2017;19(1):18.

Article  PubMed  PubMed Central  Google Scholar 

Sanchez-Lopez E, Coras R, Torres A, Lane NE, Guma M. Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol. 2022;18(5):258–75.

Article  PubMed  PubMed Central  Google Scholar 

Blankstein M, Lentine B, Nelms NJ. Common practices in intra-articular corticosteroid injection for the treatment of knee osteoarthritis: a survey of the American Association of hip and knee surgeons membership. J Arthroplasty. 2021;36(3):845–50.

Article  PubMed  Google Scholar 

Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Rheumatol. 2020;72(2):220–33.

Article  PubMed  Google Scholar 

Bannuru RR, Osani MC, Vaysbrot EE, Arden NK, Bennell K, Bierma-Zeinstra SMA, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthr Cartil. 2019;27(11):1578–89.

Article  CAS  Google Scholar 

Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JW, Dieppe P, et al. EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 2003;62(12):1145–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kloppenburg M, Kroon FP, Blanco FJ, Doherty M, Dziedzic KS, Greibrokk E, et al. 2018 update of the EULAR recommendations for the management of hand osteoarthritis. Ann Rheum Dis. 2019;78(1):16–24.

Article  PubMed  Google Scholar 

Boutin RD, Pai J, Meehan JP, Newman JS, Yao L. Rapidly progressive idiopathic arthritis of the hip: incidence and risk factors in a controlled cohort study of 1471 patients after intra-articular corticosteroid injection. Skelet Radiol. 2021;50(12):2449–57.

Article  Google Scholar 

Latourte A, Rat AC, Omorou A, Ngueyon-Sime W, Eymard F, Sellam J, et al. Do glucocorticoid injections increase the risk of knee osteoarthritis progression over 5 years? Arthritis Rheumatol. 2022;74(8):1343–51.

Article  CAS  PubMed  Google Scholar 

McAlindon TE, LaValley MP, Harvey WF, Price LL, Driban JB, Zhang M, et al. Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial. JAMA. 2017;317(19):1967–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanguino RA, Sood V, Santiago KA, Cheng J, Casey E, Mintz D, et al. Prevalence of rapidly progressive osteoarthritis of the hip following intra-articular steroid injections. PM R. 2022. https://doi.org/10.1002/pmrj.12853.

Article  PubMed  Google Scholar 

Zeng C, Lane NE, Hunter DJ, Wei J, Choi HK, McAlindon TE, et al. Intra-articular corticosteroids and the risk of knee osteoarthritis progression: results from the Osteoarthritis Initiative. Osteoarthr Cartil. 2019;27(6):855–62.

Article  CAS  Google Scholar 

Yavuz U, Sökücü S, Albayrak A, Oztürk K. Efficacy comparisons of the intraarticular steroidal agents in the patients with knee osteoarthritis. Rheumatol Int. 2012;32(11):3391–6.

Article  CAS  PubMed  Google Scholar 

Pyne D, Ioannou Y, Mootoo R, Bhanji A. Intra-articular steroids in knee osteoarthritis: a comparative study of triamcinolone hexacetonide and methylprednisolone acetate. Clin Rheumatol. 2004;23(2):116–20.

Article  PubMed  Google Scholar 

Cushman DM, Bruno B, Christiansen J, Schultz A, McCormick ZL. Efficacy of injected corticosteroid type, dose, and volume for pain in large joints: a narrative review. PM R. 2018;10(7):748–57.

Article  PubMed  Google Scholar 

Buyuk AF, Kilinc E, Camurcu IY, Camur S, Ucpunar H, Kara A. Compared efficacy of intra-articular injection of methylprednisolone and triamcinolone. Acta Ortop Bras. 2017;25(5):206–8.

Lomonte AB, de Morais MG, de Carvalho LO, Zerbini CA. Efficacy of triamcinolone hexacetonide versus methylprednisolone acetate intraarticular injections in knee osteoarthritis: a randomized, double-blinded, 24-week study. J Rheumatol. 2015;42(9):1677–84.

Article  CAS  PubMed  Google Scholar 

Spitzer AI, Richmond JC, Kraus VB, Gomoll A, Jones DG, Huffman KM, et al. Safety and efficacy of repeat administration of triamcinolone acetonide extended-release in osteoarthritis of the knee: a phase 3b, open-label study. Rheumatol Ther. 2019;6(1):109–24.

Article  PubMed  PubMed Central  Google Scholar 

Baraf H, Lattermann C, Jones D, Conaghan P, Lufkin J, Johnson J, et al. Effectiveness of FX006 intra-articular injection in patients with knee osteoarthritis who present with and without clinical inflammation at baseline: a pooled analysis of data from 3 double-blind, randomized, parallel-group clinical trials. Am Coll Rheumato. 2017;69(10).

Conaghan PG, Hunter DJ, Cohen SB, Kraus VB, Berenbaum F, Lieberman JR, et al. Effects of a single intra-articular injection of a microsphere formulation of triamcinolone acetonide on knee osteoarthritis pain: a double-blinded, randomized, placebo-controlled, multinational study. J Bone Jt Surg Am. 2018;100(8):666–77.

Article  Google Scholar 

Segal NA, Kothari MD. Interim results: the effect of intra-articular extended-release triamcinolone acetonide on OARSI-recommended physical performance measures in adults with bilateral symptomatic knee OA. Osteoarthr Cartil. 2021;29:S287–8.

Article  Google Scholar 

Malone A, Price J, Price N, Peck V, Getgood A, Petrella R, et al. Safety and pharmacokinetics of EP-104IAR (sustained-release fluticasone propionate) in knee osteoarthritis: a randomized, double-blind, placebo-controlled phase 1 trial. Osteoarthr Cartil Open. 2021;3(4).

Hunter DJ, Chang CC, Wei JC, Lin HY, Brown C, Tai TT, et al. TLC599 in patients with osteoarthritis of the knee: a phase IIa, randomized, placebo-controlled, dose-finding study. Arthritis Res Ther. 2022;24(1):52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hangody L, Szody R, Lukasik P, Zgadzaj W, Lénárt E, Dokoupilova E, et al. Intraarticular injection of a cross-linked sodium hyaluronate combined with triamcinolone hexacetonide (cingal) to provide symptomatic relief of osteoarthritis of the knee: a randomized, double-blind, placebo-controlled multicenter clinical trial. Cartilage. 2018;9(3):276–83.

Article  CAS  PubMed  Google Scholar 

Healio. Anika Therapeutics obtains CE mark for Cingal to treat OA knee pain [media release]. 2016. https://www.healio.com/. Accessed 15 Mar 2023.

Healio. Health Canada approves CINGAL as medical device to treat knee OA pain [media release]. 2015. https://www.healio.com/. Accessed 15 Mar 2023.

Fierce Biotech. Anika’s combo arthritis drug Cingal flunks phase 3 test [media release]. 2018. https://www.fiercebiotech.com/. Accessed 15 Mar 2023.

Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7(1):33–42.

Article  CAS  PubMed  Google Scholar 

Takano S, Uchida K, Miyagi M, Inoue G, Fujimaki H, Aikawa J, et al. Nerve growth factor regulation by TNF-α and IL-1β in synovial macrophages and fibroblasts in osteoarthritic mice. J Immunol Res. 2016;2016:5706359.

Article  PubMed  PubMed Central  Google Scholar 

Vasudeva A, Yadav SL, Nanda S, Sahu S. Assessment of pain and structure after an intra-articular injection of adalimumab in osteoarthritis of the knee: a case report. Medicine (Baltimore). 2020;99(28): e21131.

Article  PubMed  Google Scholar 

Wang J. Efficacy and safety of adalimumab by intra-articular injection for moderate to severe knee osteoarthritis: An open-label randomized controlled trial. J Int Med Res. 2018;46(1):326–34.

Article  CAS  PubMed  Google Scholar 

Fioravanti A, Fabbroni M, Cerase A, Galeazzi M. Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study. Rheumatol Int. 2009;29(8):961–5.

Article  CAS  PubMed  Google Scholar 

Lindsley HB, Schue J, Tawfik O, Bolce R, Smith DD, Hinson G, et al. Treatment of knee osteoarthritis with intra-articular infliximab improves total WOMAC score. High baseline levels of synovital cellularity predict improvement. Ann Rheum Dis. 2012;71(3):417.

Ohtori S, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kishida S, et al. Efficacy of direct injection of etanercept into knee joints for pain in moderate and severe knee osteoarthritis. Yonsei Med J. 2015;56(5):1379–83.

Article  PubMed  PubMed Central  Google Scholar 

Lv M, Zhou Y, Polson SW, Wan LQ, Wang M, Han L, et al. Identification of chondrocyte genes and signaling pathways in response to acute joint inflammation. Sci Rep. 2019;9(1):93.

Article  PubMed  PubMed Central  Google Scholar 

Schieker M, Mindeholm L, Praestgaard J, Scotti C, Solomon D, Thuren T, et al. Interleukin-1β inhibition with canakinumab associates with reduced rates of total hip and knee replacement (THR/TKR) and osteoarthritis (OA) symptoms: exploratory results from the canakinumab anti-inflammatory thrombosis outcomes study (CANTOS). Am Coll Rheumatol. 2018;70(9).

Cheleschi S, Cantarini L, Pascarelli NA, Collodel G, Lucherini OM, Galeazzi M, et al. Possible chondroprotective effect of canakinumab: an in vitro study on human osteoarthritic chondrocytes. Cytokine. 2015;71(2):165–72.

留言 (0)

沒有登入
gif